DGIdb - GYPA Gene Record

GYPA 2993 Druggable Genome

Alternate Names:

2993
GLYCOPHORIN A (MNS BLOOD GROUP)
GYPA
CD235a
GPA
GPErik
GPSAT
HGpMiV
HGpMiXI
HGpSta(C)
MN
MNS
PAS-2
111300
4702
ENSG00000170180
OTTHUMG00000161403
P02724
617922

Gene Info:

Target Class	Miscellaneous
Target Subclass	Miscellaneous
Target Subclass	membrane protein
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Krömer et al., 1998, Expression of the membrane protein glycophorin A as a fusion with the antibiotic resistance protein neomycin phosphotransferase II., Biotechnol. Bioeng.
Torikai et al., 2006, Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A., Bioorg. Med. Chem. Lett.
Ujihara S et al., 2008, Interaction of ladder-shaped polyethers with transmembrane alpha-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance., Bioorg Med Chem Lett

YESSOTOXIN GYPA

Interaction Score: 30.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18947999

Sources:
DTC
GIRENTUXIMAB GYPA

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name WX-G250,Rencarex

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
NEOMYCIN GYPA

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10099199

Sources:
NCI
ETHER GYPA

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16989999

Sources:
NCI

Ensembl: ENSG00000170180
- Version: 101_38
Alternate Names:

GYPA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P02724
- Version: January-2014
Alternate Names:

GYPA Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass membrane protein

Publications:

NCI: GYPA

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Benoist et al., 1989, Comparative effects of fagaronine, adriamycin and aclacinomycin on K562 cell sensitivity to natural-killer-mediated lysis. Lack of agreement between alteration of transferrin receptor and CD15 antigen expressions and induction of resistance to natural killer., Cancer Immunol. Immunother.

Waśniowska et al., 2000, Expression and binding properties of a soluble chimeric protein containing the N-terminal domain of the Duffy antigen., Biochem. Biophys. Res. Commun.

Krömer et al., 1998, Expression of the membrane protein glycophorin A as a fusion with the antibiotic resistance protein neomycin phosphotransferase II., Biotechnol. Bioeng.

DTC: GYPA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Ujihara S et al., 2008, Interaction of ladder-shaped polyethers with transmembrane alpha-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000170180
- Version: 31-May-2017
Alternate Names:

ENSG00000170180 Gene Symbol

GYPA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: GYPA
- Version: 01-February-2022
Alternate Names:

GPA GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Trial Name	WX-G250,Rencarex
Novel drug target	Novel Target

GYPA Gene Record

GYPA 2993 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

YESSOTOXIN GYPA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18947999

Sources: DTC

GIRENTUXIMAB GYPA

Interaction Types & Directionality: n/a

Interaction Info: Trial Name WX-G250,Rencarex Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

NEOMYCIN GYPA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10099199

Sources: NCI

ETHER GYPA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16989999

Sources: NCI

Ensembl: ENSG00000170180

Alternate Names: GYPA Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P02724

Alternate Names: GYPA Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Miscellaneous Target Subclass membrane protein

Publications:

NCI: GYPA

Alternate Names:

Gene Info:

DTC: GYPA

Alternate Names:

Gene Info:

Publications: Ujihara S et al., 2008, Interaction of ladder-shaped polyethers with transmembrane alpha-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000170180

Alternate Names: ENSG00000170180 Gene Symbol GYPA Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: GYPA

Alternate Names: GPA GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18947999

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name WX-G250,Rencarex

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
10099199

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16989999

Sources:
NCI

Alternate Names:

GYPA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GYPA Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass membrane protein

Publications:

Ujihara S et al., 2008, Interaction of ladder-shaped polyethers with transmembrane alpha-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance., Bioorg Med Chem Lett

Alternate Names:

ENSG00000170180 Gene Symbol

GYPA Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GPA GO Gene Synonym

Gene Categories:

CELL SURFACE