DGIdb - HCK Gene Record

HCK 3055 Druggable Genome

Alternate Names:

3055
HCK PROTO-ONCOGENE, SRC FAMILY TYROSINE KINASE
HCK
JTK9
p59Hck
p61Hck
142370
4840
ENSG00000101336
OTTHUMG00000032204
P08631
p59-HCK/p60-HCK
Tyrosine-protein kinase HCK
Hemopoietic cell kinase
Hematopoietic cell kinase
HCK_HUMAN
TYROSINE-PROTEIN KINASE HCK (EC 2.7.1.112) (P59-HCK/P60-HCK) (HEMOPOIETIC CELL KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P08631]
T31406

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Human Readable Name	KINASE
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Acc	IPR001245
Initial Gene Query	HCK
Counted Citations from 1950-2000	469
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Donato et al., 2003, BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571., Blood

IMATINIB MESYLATE HCK

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12509383

Sources:
NCI
BOSUTINIB HCK

Interaction Score: 0.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase HCK inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
MASITINIB HCK

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name masitinib, AB1010

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TG100-801 HCK

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XL-228 HCK

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DORAMAPIMOD HCK

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NINTEDANIB HCK

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
MLN-8054 HCK

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENMD-981693 HCK

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL406845 HCK

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AST-487 HCK

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DASATINIB HCK

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
HESPERADIN HCK

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
GEFITINIB HCK

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 HCK

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB HCK

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 HCK

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB HCK

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000101336
- Version: 101_38
Alternate Names:

HCK Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: HCK
- Version: February-2014
Alternate Names:

3055 Entrez Gene ID

Gene Info:

Initial Gene Query HCK

Counted Citations from 1950-2000 469

Gene Categories:

KINASE

Publications:
TdgClinicalTrial: P08631
- Version: January-2014
Alternate Names:

HCK Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:

RussLampel: ENSG00000101336

Version: 26-July-2011

Alternate Names:

HCK Display Id

ENSG00000101336 Ensembl Gene Id

TYROSINE-PROTEIN KINASE HCK (EC 2.7.1.112) (P59-HCK/P60-HCK) (HEMOPOIETIC CELL KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P08631] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P08631
- Version: 11-September-2012
Alternate Names:

ENSG00000101336 Ensembl Gene Id

HCK Uniprot Gene Name

P08631 Uniprot Accession

Gene Info:

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Human Readable Name KINASE

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

NCI: HCK

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ernst et al., 1994, Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells., EMBO J.

Donato et al., 2003, BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571., Blood

DTC: HCK
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
TALC: HCK
- Version: 12-May-2016
Alternate Names:

HCK Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000101336
- Version: 31-May-2017
Alternate Names:

ENSG00000101336 Gene Symbol

HCK Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HCK
- Version: chembl_23
Alternate Names:

HCK GENE_SYMBOL

Tyrosine-protein kinase HCK UNIPROT

Hematopoietic cell kinase UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: HCK
- Version: 19.3
Alternate Names:

ENSG00000101336 Ensembl Gene ID

JTK9 Human Protein Atlas Gene Synonym

HCK proto-oncogene, Src family tyrosine kinase Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
dGene: HCK
- Version: 27-Jun-2013
Alternate Names:

3055 Gene ID

JTK9 dGene Synonym

p59Hck dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Hematopoietic cell kinase
- Version: 2020.06.01
Alternate Names:

HCK TTD Gene Abbreviation

T31406 TTD Target ID

Gene Info:

Publications:
Pharos: HCK
- Version: 01-February-2022
Alternate Names:

Tyrosine-protein kinase HCK Gene Name

P08631 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: HCK
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

TYROSINE KINASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Tyrosine-protein kinase HCK inhibitor

HCK	Display Id
ENSG00000101336	Ensembl Gene Id
TYROSINE-PROTEIN KINASE HCK (EC 2.7.1.112) (P59-HCK/P60-HCK) (HEMOPOIETIC CELL KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P08631]	Description

ENSG00000101336	Ensembl Gene Id
HCK	Uniprot Gene Name
P08631	Uniprot Accession

HCK	GENE_SYMBOL
Tyrosine-protein kinase HCK	UNIPROT
Hematopoietic cell kinase	UNIPROT

Trial Name	masitinib, AB1010
Novel drug target	Novel Target

HCK Gene Record

HCK 3055 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12509383

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase HCK inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name masitinib, AB1010 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction SRC inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

PMIDs: None found

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction SRC inhibitor

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000101336

Alternate Names: HCK Ensembl Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
12509383

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase HCK inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name masitinib, AB1010

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

HCK Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

3055 Entrez Gene ID

Gene Info:

Initial Gene Query HCK

Counted Citations from 1950-2000 469

Gene Categories:

KINASE

Alternate Names:

HCK Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Alternate Names:

HCK Display Id

ENSG00000101336 Ensembl Gene Id

TYROSINE-PROTEIN KINASE HCK (EC 2.7.1.112) (P59-HCK/P60-HCK) (HEMOPOIETIC CELL KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P08631] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000101336 Ensembl Gene Id

HCK Uniprot Gene Name

P08631 Uniprot Accession

Gene Info:

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Human Readable Name KINASE

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Alternate Names:

HCK Gene Symbol

Alternate Names:

ENSG00000101336 Gene Symbol

HCK Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HCK GENE_SYMBOL

Tyrosine-protein kinase HCK UNIPROT

Hematopoietic cell kinase UNIPROT