HCRTR1 Gene Record

  • HCRTR1 3061 Druggable Genome

    Alternate Names:

    3061
    HYPOCRETIN RECEPTOR 1
    HCRTR1
    OX1R
    602392
    4848
    ENSG00000121764
    OTTHUMG00000003876
    HYPOCRETIN RECEPTOR TYPE 1
    O43613
    OREXIN RECEPTOR TYPE 1
    Ox-1-R
    Ox1-R
    OREXIN RECEPTOR TYPE 1 (OX1R) (HYPOCRETIN RECEPTOR TYPE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:O43613]
    OX1R_HUMAN
    T73482
    ORXR1
    OXR1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

  • SUVOREXANT   HCRTR1

    Interaction Score: 18.55

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Orexin receptor antagonist
    Trial Name MK-4305

    PMIDs:
    23702225


    Sources:
    TdgClinicalTrial ChemblInteractions

  • SB-649868   HCRTR1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Orexin receptor 1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ALMOREXANT   HCRTR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name almorexant, ACT-078573
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LEMBOREXANT   HCRTR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Orexin receptor 1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL1520346   HCRTR1

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000121764

    • Version: 101_38

    Alternate Names:
    HCRTR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000121764

    • Version: 26-July-2011

    Alternate Names:
    HCRTR1 Display Id
    ENSG00000121764 Ensembl Gene Id
    OREXIN RECEPTOR TYPE 1 (OX1R) (HYPOCRETIN RECEPTOR TYPE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:O43613] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: O43613

    • Version: January-2014

    Alternate Names:
    HCRTR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: O43613

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000121764 Ensembl Gene Id
    OREXIN RECEPTOR TYPE 1 Uniprot Protein Name
    3061 Entrez Gene Id

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HCRTR1

    • Version: chembl_23

    Alternate Names:
    Ox-1-R UNIPROT
    Ox1-R UNIPROT
    HCRTR1 GENE_SYMBOL

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000121764

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000121764 Gene Symbol
    HCRTR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: HCRTR1

    • Version: 27-Jun-2013

    Alternate Names:
    3061 Gene ID
    OX1R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Orexin receptor type 1

    • Version: 2020.06.01

    Alternate Names:
    HCRTR1 TTD Gene Abbreviation
    T73482 TTD Target ID

    Gene Info:

    Publications:

  • DTC: HCRTR1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: HCRTR1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications: