DGIdb - HSD3B1 Gene Record

HSD3B1 3283 Druggable GenomeClinically Actionable

Alternate Names:

3283
HYDROXY-DELTA-5-STEROID DEHYDROGENASE, 3 BETA- AND STEROID DELTA-ISOMERASE 1
HSD3B1
3BETAHSD
HSD3B
HSDB3
HSDB3A
I
SDR11E1
109715
5217
ENSG00000203857
OTTHUMG00000012525
P14060
3BHS1_HUMAN
ENSG00000175511
3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE TYPE I (3BETA-HSD I) (TROPHOBLAST ANTIGEN FDO161G) [INCLUDES: 3-BETA-HYDROXY- DELTA(5)-STEROID DEHYDROGENASE (EC 1.1.1.145) (3-BETA-HYDROXY-5-ENE STEROID DEHYDROGENASE) (PROGESTERONE REDUCTASE); ST
PA29486
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.1.1.145/5.3.3.1
Target Subclass	1.1.1.145/5.3.3.1
Target Main Class	Enzymes
Transmembrane Helix Count	1
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Mensah-Nyagan et al., 1994, Immunocytochemical localization and biological activity of 3 beta-hydroxysteroid dehydrogenase in the central nervous system of the frog., J. Neurosci.
Cooke, 1996, Differential effects of trilostane and cyanoketone on the 3 beta-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis., J. Steroid Biochem. Mol. Biol.
Suzuki et al., 1984, Indirect immunofluorescence studies on the steroid-producing activity of hamster ova., Am. J. Obstet. Gynecol.
Naville et al., 1991, Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase., Mol. Endocrinol.
Igaz et al., 2008, Steroid biosynthesis inhibitors in the therapy of hypercortisolism: theory and practice., Curr. Med. Chem.
Duffy et al., 1994, Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone., J. Clin. Endocrinol. Metab.
Takahashi et al., 1990, Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3 beta-hydroxysteroid dehydrogenase/5----4-ene-isomerase activity., J. Steroid Biochem. Mol. Biol.

TRILOSTANE HSD3B1

Interaction Score: 92.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7996177 8809191 6362415 1944305 18991633 7989460 2268554

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000203857
- Version: 101_38
Alternate Names:

HSD3B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P14060
- Version: January-2014
Alternate Names:

HSD3B1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.1.1.145/5.3.3.1

Publications:

RussLampel: ENSG00000175511

Version: 26-July-2011

Alternate Names:

3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE TYPE I (3BETA-HSD I) (TROPHOBLAST ANTIGEN FDO161G) [INCLUDES: 3-BETA-HYDROXY- DELTA(5)-STEROID DEHYDROGENASE (EC 1.1.1.145) (3-BETA-HYDROXY-5-ENE STEROID DEHYDROGENASE) (PROGESTERONE REDUCTASE); ST Description

ENSG00000175511 Ensembl Gene Id

HSD3B1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P14060
- Version: 01-August-2011
Alternate Names:

3BHS1_HUMAN Uniprot Id

P14060 Uniprot Accession

ENSG00000203857 Ensembl Gene Id

Gene Info:

Target Subclass 1.1.1.145/5.3.3.1

Target Main Class Enzymes

Transmembrane Helix Count 1

Publications:
PharmGKB: HSD3B1
- Version: 18-August-2020
Alternate Names:

PA29486 PharmGKB ID

Gene Info:

Publications:

Zein J et al., 2020, <i>HSD3B1</i> genotype identifies glucocorticoid responsiveness in severe asthma., Proc Natl Acad Sci U S A
HingoraniCasas: ENSG00000203857
- Version: 31-May-2017
Alternate Names:

ENSG00000203857 Gene Symbol

HSD3B1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: HSD3B1
- Version: 01-February-2022
Alternate Names:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Gene Name

P14060 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
FoundationOneGenes: HSD3B1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE TYPE I (3BETA-HSD I) (TROPHOBLAST ANTIGEN FDO161G) [INCLUDES: 3-BETA-HYDROXY- DELTA(5)-STEROID DEHYDROGENASE (EC 1.1.1.145) (3-BETA-HYDROXY-5-ENE STEROID DEHYDROGENASE) (PROGESTERONE REDUCTASE); ST	Description
ENSG00000175511	Ensembl Gene Id
HSD3B1	Display Id

3BHS1_HUMAN	Uniprot Id
P14060	Uniprot Accession
ENSG00000203857	Ensembl Gene Id

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	Gene Name
P14060	UniProt ID

Novel drug target	Established target
Trial Name	-

HSD3B1 Gene Record

HSD3B1 3283 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TRILOSTANE HSD3B1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 7996177 8809191 6362415 1944305 18991633 7989460 2268554

Sources: TdgClinicalTrial TEND

Ensembl: ENSG00000203857

Alternate Names: HSD3B1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P14060

Alternate Names: HSD3B1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.1.1.145/5.3.3.1

Publications:

RussLampel: ENSG00000175511

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P14060

Alternate Names: 3BHS1_HUMAN Uniprot Id P14060 Uniprot Accession ENSG00000203857 Ensembl Gene Id

Gene Info: Target Subclass 1.1.1.145/5.3.3.1 Target Main Class Enzymes Transmembrane Helix Count 1

Publications:

PharmGKB: HSD3B1

Alternate Names: PA29486 PharmGKB ID

Gene Info:

Publications: Zein J et al., 2020, <i>HSD3B1</i> genotype identifies glucocorticoid responsiveness in severe asthma., Proc Natl Acad Sci U S A

HingoraniCasas: ENSG00000203857

Alternate Names: ENSG00000203857 Gene Symbol HSD3B1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: HSD3B1

Alternate Names: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Gene Name P14060 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

FoundationOneGenes: HSD3B1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7996177 8809191 6362415 1944305 18991633 7989460 2268554

Sources:
TdgClinicalTrial TEND

Alternate Names:

HSD3B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HSD3B1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.1.1.145/5.3.3.1

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3BHS1_HUMAN Uniprot Id

P14060 Uniprot Accession

ENSG00000203857 Ensembl Gene Id

Gene Info:

Target Subclass 1.1.1.145/5.3.3.1

Target Main Class Enzymes

Transmembrane Helix Count 1

Alternate Names:

PA29486 PharmGKB ID

Publications:

Zein J et al., 2020, <i>HSD3B1</i> genotype identifies glucocorticoid responsiveness in severe asthma., Proc Natl Acad Sci U S A

Alternate Names:

ENSG00000203857 Gene Symbol

HSD3B1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Gene Name

P14060 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CLINICALLY ACTIONABLE