DGIdb - HTR1F Gene Record

HTR1F 3355 Druggable Genome

Alternate Names:

3355
5-HYDROXYTRYPTAMINE RECEPTOR 1F
HTR1F
5-HT-1F
5-HT1F
5HT6
HTR1EL
MR77
182134
5292
ENSG00000179097
OTTHUMG00000159008
P30939
5HT1F_HUMAN
Serotonin receptor 1F
5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR 1F). [SOURCE:UNIPROT/SWISSPROT;ACC:P30939]
5-HT 1F receptor
T78656

Gene Info:

Transmembrane Helix Count	7
Target Subclass	GPCR
Target Main Class	Receptors
Target Subclass	Rhodopsin
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Status	Swiss-Prot
Interpro Type	Family
Uniprot Evidence	2: Evidence at transcript level
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
Massiou, 2001, Naratriptan., Curr Med Res Opin
Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hoskin et al., 2004, The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat., Brain Res.
Villalón et al., 2003, Migraine: pathophysiology, pharmacology, treatment and future trends., Curr Vasc Pharmacol
Goadsby et al., 2003, Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input., Neuroscience
Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
Pauwels et al., Present and future of 5-HT receptor agonists as antimigraine drugs., Clin Neuropharmacol
Janssen et al., 2004, Influence of 5-HT1 receptor agonists on feline stomach relaxation., Eur. J. Pharmacol.
Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
Cohen et al., 2000, Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha)., Br. J. Pharmacol.
Razzaque et al., 1999, Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation., Br J Clin Pharmacol
Reuter U et al., 2015, The pharmacological profile and clinical prospects of the oral 5-HT1F receptor agonist lasmiditan in the acute treatment of migraine., Ther Adv Neurol Disord
Wainscott et al., 1998, Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation., Eur. J. Pharmacol.
Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
Bhalla et al., 2002, Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor., Eur. J. Pharmacol.
Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther

LASMIDITAN HTR1F

Interaction Score: 35.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lasmiditan, COL-144, LY-573144

Novel drug target Established target

Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

PMIDs:
25584073

Sources:
TdgClinicalTrial ChemblInteractions TTD
NARATRIPTAN HTR1F

Interaction Score: 19.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name naratriptan,Naramig, Amerge

PMIDs:
11152011 12463278 12434581 11752352 14725972 15320857 14614913

Sources:
TdgClinicalTrial TEND
ZOLMITRIPTAN HTR1F

Interaction Score: 17.67

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name zolmitriptan,Zomig

Novel drug target Established target

PMIDs:
12434581 9718276 11752352 15096229 15320857 11834243 9399012 29352859

Sources:
TdgClinicalTrial TEND
CHEMBL101690 HTR1F

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SUMATRIPTAN HTR1F

Interaction Score: 6.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name sumatriptan,Imitrex

Novel drug target Established target

Trial Name MT 400,Treximet

PMIDs:
12110114 10225363 10367177 15178373 18723285 11752352 11015308 10073743

Sources:
TdgClinicalTrial TEND
ELETRIPTAN HYDROBROMIDE HTR1F

Interaction Score: 2.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALMOTRIPTAN MALATE HTR1F

Interaction Score: 2.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000179097
- Version: 101_38
Alternate Names:

HTR1F Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P30939
- Version: 01-August-2011
Alternate Names:

ENSG00000179097 Ensembl Gene Id

P30939 Uniprot Accession

HTR1F Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Main Class Receptors

Publications:
RussLampel: ENSG00000179097
- Version: 26-July-2011
Alternate Names:

ENSG00000179097 Ensembl Gene Id

5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR 1F). [SOURCE:UNIPROT/SWISSPROT;ACC:P30939] Description

HTR1F Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30939
- Version: January-2014
Alternate Names:

HTR1F Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P30939
- Version: 11-September-2012
Alternate Names:

HTR1F Uniprot Gene Name

3355 Entrez Gene Id

P30939 Uniprot Accession

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000179097
- Version: 31-May-2017
Alternate Names:

ENSG00000179097 Gene Symbol

HTR1F Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HTR1EL
- Version: chembl_23
Alternate Names:

HTR1EL GENE_SYMBOL

HTR1F GENE_SYMBOL

5-hydroxytryptamine receptor 1F UNIPROT

Gene Info:

Publications:
dGene: HTR1F
- Version: 27-Jun-2013
Alternate Names:

3355 Gene ID

5-HT-1F dGene Synonym

5-HT1F dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 1F receptor
- Version: 2020.06.01
Alternate Names:

HTR1F TTD Gene Abbreviation

T78656 TTD Target ID

Gene Info:

Publications:

Trial Name	lasmiditan, COL-144, LY-573144
Novel drug target	Established target
Mechanism of Interaction	Serotonin 1f (5-HT1f) receptor agonist

Trial Name	zolmitriptan,Zomig
Novel drug target	Established target

Trial Name	sumatriptan,Imitrex
Novel drug target	Established target
Trial Name	MT 400,Treximet

Mechanism of Interaction	Serotonin 1f (5-HT1f) receptor agonist
Direct Interaction	yes

ENSG00000179097	Ensembl Gene Id
P30939	Uniprot Accession
HTR1F	Gene Symbol

HTR1F	Uniprot Gene Name
3355	Entrez Gene Id
P30939	Uniprot Accession

HTR1EL	GENE_SYMBOL
HTR1F	GENE_SYMBOL
5-hydroxytryptamine receptor 1F	UNIPROT

HTR1F Gene Record

HTR1F 3355 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

LASMIDITAN HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name lasmiditan, COL-144, LY-573144 Novel drug target Established target Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

PMIDs: 25584073

Sources: TdgClinicalTrial ChemblInteractions TTD

NARATRIPTAN HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name naratriptan,Naramig, Amerge

PMIDs: 11152011 12463278 12434581 11752352 14725972 15320857 14614913

Sources: TdgClinicalTrial TEND

ZOLMITRIPTAN HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name zolmitriptan,Zomig Novel drug target Established target

PMIDs: 12434581 9718276 11752352 15096229 15320857 11834243 9399012 29352859

Sources: TdgClinicalTrial TEND

CHEMBL101690 HTR1F

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

SUMATRIPTAN HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name sumatriptan,Imitrex Novel drug target Established target Trial Name MT 400,Treximet

PMIDs: 12110114 10225363 10367177 15178373 18723285 11752352 11015308 10073743

Sources: TdgClinicalTrial TEND

ELETRIPTAN HYDROBROMIDE HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ALMOTRIPTAN MALATE HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000179097

Alternate Names: HTR1F Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P30939

Alternate Names: ENSG00000179097 Ensembl Gene Id P30939 Uniprot Accession HTR1F Gene Symbol

Gene Info: Transmembrane Helix Count 7 Target Subclass GPCR Target Main Class Receptors

Publications:

RussLampel: ENSG00000179097

Alternate Names: ENSG00000179097 Ensembl Gene Id 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR 1F). [SOURCE:UNIPROT/SWISSPROT;ACC:P30939] Description HTR1F Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P30939

Alternate Names: HTR1F Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

HopkinsGroom: P30939

Alternate Names: HTR1F Uniprot Gene Name 3355 Entrez Gene Id P30939 Uniprot Accession

Gene Info: Human Readable Name G PROTEIN COUPLED RECEPTOR Human Readable Name DRUGGABLE GENOME Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

HingoraniCasas: ENSG00000179097

Alternate Names: ENSG00000179097 Gene Symbol HTR1F Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: HTR1EL

Alternate Names: HTR1EL GENE_SYMBOL HTR1F GENE_SYMBOL 5-hydroxytryptamine receptor 1F UNIPROT

Gene Info:

Publications:

dGene: HTR1F

Alternate Names: 3355 Gene ID 5-HT-1F dGene Synonym 5-HT1F dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

TTD: 5-HT 1F receptor

Alternate Names: HTR1F TTD Gene Abbreviation T78656 TTD Target ID

Gene Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name lasmiditan, COL-144, LY-573144

Novel drug target Established target

Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

PMIDs:
25584073

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name naratriptan,Naramig, Amerge

PMIDs:
11152011 12463278 12434581 11752352 14725972 15320857 14614913

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name zolmitriptan,Zomig

Novel drug target Established target

PMIDs:
12434581 9718276 11752352 15096229 15320857 11834243 9399012 29352859

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name sumatriptan,Imitrex

Novel drug target Established target

Trial Name MT 400,Treximet

PMIDs:
12110114 10225363 10367177 15178373 18723285 11752352 11015308 10073743

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

HTR1F Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000179097 Ensembl Gene Id

P30939 Uniprot Accession

HTR1F Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Main Class Receptors

Alternate Names:

ENSG00000179097 Ensembl Gene Id

5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR 1F). [SOURCE:UNIPROT/SWISSPROT;ACC:P30939] Description

HTR1F Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HTR1F Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

HTR1F Uniprot Gene Name

3355 Entrez Gene Id

P30939 Uniprot Accession

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

ENSG00000179097 Gene Symbol

HTR1F Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HTR1EL GENE_SYMBOL

HTR1F GENE_SYMBOL

5-hydroxytryptamine receptor 1F UNIPROT

Alternate Names:

3355 Gene ID

5-HT-1F dGene Synonym

5-HT1F dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

HTR1F TTD Gene Abbreviation

T78656 TTD Target ID