HTR3E Gene Record

  • HTR3E 285242 Druggable Genome

    Alternate Names:

    285242
    5-HYDROXYTRYPTAMINE RECEPTOR 3E
    HTR3E
    5-HT3-E
    5-HT3E
    5-HT3c1
    610123
    24005
    ENSG00000186038
    OTTHUMG00000156857
    5-HYDROXYTRYPTAMINE RECEPTOR 3 SUBUNIT E [SOURCE:REFSEQ_PEPTIDE;ACC:NP_872395]
    Serotonin receptor 3E
    A5X5Y0
    5HT3E_HUMAN
    PA134900226

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    Target Subclass TC:1.A.9
    Interpro Name Neurotransmitter-gated ion-channel
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR006201
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Type Domain
    Human Readable Name ION CHANNEL
    Uniprot Status Swiss-Prot
    Interpro Acc IPR006202
    Interpro Short Name Neur_chan_lig-bd
    Interpro Short Name Neur_channel
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

  • PUMOSETRAG   HTR3E

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Pumosetrag
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RG3487   HTR3E

    Interaction Score: 1.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 3 (5-HT3) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOLASETRON   HTR3E

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name dolasetron mesylate,Anzemet
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TEDATIOXETINE   HTR3E

    Interaction Score: 0.79

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 3 (5-HT3) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GRANISETRON   HTR3E

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name granisetron (intranasal), TRG
    Novel drug target Established target
    Trial Name granisetron nasal spray

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • HALOPERIDOL   HTR3E

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023437


    Sources:
    PharmGKB

  • Ensembl: ENSG00000186038

    • Version: 101_38

    Alternate Names:
    HTR3E Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000186038

    • Version: 26-July-2011

    Alternate Names:
    HTR3E Display Id
    5-HYDROXYTRYPTAMINE RECEPTOR 3 SUBUNIT E [SOURCE:REFSEQ_PEPTIDE;ACC:NP_872395] Description
    ENSG00000186038 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: A5X5Y0

    • Version: January-2014

    Alternate Names:
    HTR3E Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9

    Publications:

  • HopkinsGroom: A5X5Y0

    • Version: 11-September-2012

    Alternate Names:
    HTR3E Uniprot Gene Name
    5-HYDROXYTRYPTAMINE RECEPTOR 3E Uniprot Protein Name
    285242 Entrez Gene Id

    Gene Info:
    Interpro Name Neurotransmitter-gated ion-channel
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR006201

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • PharmGKB: HTR3E

    • Version: 18-August-2020

    Alternate Names:
    PA134900226 PharmGKB ID

    Gene Info:

    Publications:
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

  • ChemblInteractions: HTR3E

    • Version: chembl_23

    Alternate Names:
    HTR3E GENE_SYMBOL
    5-hydroxytryptamine receptor 3E UNIPROT
    Serotonin receptor 3E UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000186038

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000186038 Gene Symbol
    HTR3E Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: HTR3E

    • Version: 01-February-2022

    Alternate Names:
    5-hydroxytryptamine receptor 3E Gene Name
    A5X5Y0 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: