DGIdb - HTR6 Gene Record

HTR6 3362 Druggable Genome

Alternate Names:

3362
5-HYDROXYTRYPTAMINE RECEPTOR 6
HTR6
5-HT6
5-HT6R
601109
5301
ENSG00000158748
OTTHUMG00000002713
P50406
5HT6R_HUMAN
Serotonin receptor 6
5-HT-6
5-HYDROXYTRYPTAMINE 6 RECEPTOR (5-HT-6) (SEROTONIN RECEPTOR 6). [SOURCE:UNIPROT/SWISSPROT;ACC:P50406]
PA29560
5-HT 6 receptor
T16691

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Interpro Name	GPCR, rhodopsin-like, 7TM
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Target Subclass	Rhodopsin
Target Subclass	GPCR
Transmembrane Helix Count	7
Target Main Class	Receptors
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
Pouzet et al., 2002, Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia., Pharmacol. Biochem. Behav.
Mørk et al., 2009, Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved., Psychopharmacology (Berl.)
Nirogi RV et al., 2010, Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands., ACS Med Chem Lett
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Krogsgaard-Larsen N et al., 2014, Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands., J Med Chem
Ramírez MJ, 2013, 5-HT6 receptors and Alzheimer's disease., Alzheimers Res Ther
Yun HM et al., 2011, The serotonin-6 receptor as a novel therapeutic target., Exp Neurobiol
Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol

INTEPIRDINE HTR6

Interaction Score: 28.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

Direct Interaction yes

PMIDs:
24878269 23607787

Sources:
DTC ChemblInteractions TTD
MASUPIRDINE HTR6

Interaction Score: 16.86

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SUVN-502

Novel drug target Established target

PMIDs:
24900216

Sources:
TdgClinicalTrial TTD
LANDIPIRDINE HTR6

Interaction Score: 11.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22355260

Sources:
TTD
PF-05212377 HTR6

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
CERLAPIRDINE HTR6

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
IDALOPIRDINE HTR6

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

Direct Interaction yes

Trial Name Lu-AE58054 , LY-483518, SGS518

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
SERTINDOLE HTR6

Interaction Score: 2.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
11888555 19506838

Sources:
TdgClinicalTrial TEND
ASENAPINE HTR6

Interaction Score: 1.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial
ILOPERIDONE HTR6

Interaction Score: 0.75

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23272794

Sources:
TdgClinicalTrial
OLANZAPINE HTR6

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919 25032030

Sources:
TdgClinicalTrial
RISPERIDONE HTR6

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
19997080

Sources:
PharmGKB

Ensembl: ENSG00000158748
- Version: 101_38
Alternate Names:

HTR6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P50406
- Version: 01-August-2011
Alternate Names:

P50406 Uniprot Accession

3362 Entrez Gene Id

5HT6R_HUMAN Uniprot Id

Gene Info:

Target Subclass Rhodopsin

Target Subclass GPCR

Transmembrane Helix Count 7

Publications:
RussLampel: ENSG00000158748
- Version: 26-July-2011
Alternate Names:

HTR6 Display Id

ENSG00000158748 Ensembl Gene Id

5-HYDROXYTRYPTAMINE 6 RECEPTOR (5-HT-6) (SEROTONIN RECEPTOR 6). [SOURCE:UNIPROT/SWISSPROT;ACC:P50406] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P50406
- Version: January-2014
Alternate Names:

HTR6 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P50406
- Version: 11-September-2012
Alternate Names:

P50406 Uniprot Accession

ENSG00000158748 Ensembl Gene Id

3362 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Family

Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
PharmGKB: HTR6
- Version: 18-August-2020
Alternate Names:

PA29560 PharmGKB ID

Gene Info:

Publications:

Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J

TTD: 5-HT 6 receptor

Version: 2020.06.01

Alternate Names:

HTR6 TTD Gene Abbreviation

T16691 TTD Target ID

Gene Info:

Publications:

Garfield AS et al., 2009, Pharmacological targeting of the serotonergic system for the treatment of obesity., J Physiol

Sabbagh MN et al., 2010, Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea., Curr Opin Investig Drugs

Ramírez MJ, 2013, 5-HT6 receptors and Alzheimer's disease., Alzheimers Res Ther

DTC: HTR6
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Krogsgaard-Larsen N et al., 2014, Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands., J Med Chem
ChemblInteractions: HTR6
- Version: chembl_23
Alternate Names:

HTR6 GENE_SYMBOL

5-hydroxytryptamine receptor 6 UNIPROT

Serotonin receptor 6 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000158748
- Version: 31-May-2017
Alternate Names:

ENSG00000158748 Gene Symbol

HTR6 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: HTR6
- Version: 27-Jun-2013
Alternate Names:

3362 Gene ID

5-HT6 dGene Synonym

5-HT6R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	Serotonin 6 (5-HT6) receptor antagonist
Direct Interaction	yes

Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Novel drug target	Established target

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

P50406	Uniprot Accession
3362	Entrez Gene Id
5HT6R_HUMAN	Uniprot Id

HTR6	Display Id
ENSG00000158748	Ensembl Gene Id
5-HYDROXYTRYPTAMINE 6 RECEPTOR (5-HT-6) (SEROTONIN RECEPTOR 6). [SOURCE:UNIPROT/SWISSPROT;ACC:P50406]	Description

HTR6	GENE_SYMBOL
5-hydroxytryptamine receptor 6	UNIPROT
Serotonin receptor 6	UNIPROT

HTR6 Gene Record

HTR6 3362 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist Direct Interaction yes

PMIDs: 24878269 23607787

Sources: DTC ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name SUVN-502 Novel drug target Established target

PMIDs: 24900216

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22355260

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist Direct Interaction yes Trial Name Lu-AE58054 , LY-483518, SGS518

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Serdolect Novel drug target Established target

PMIDs: 11888555 19506838

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine

PMIDs: 18308814 10592235 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name iloperidone,Fanapt, Fiapta, Zomaril Novel drug target Established target

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ALKS 3831 Trial Name OREX-003, olanzapine plus zonisamide SR Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs: 17848919 25032030

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 19997080

Sources: PharmGKB

Ensembl: ENSG00000158748

Alternate Names: HTR6 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P50406

Alternate Names: P50406 Uniprot Accession 3362 Entrez Gene Id 5HT6R_HUMAN Uniprot Id

Gene Info: Target Subclass Rhodopsin Target Subclass GPCR Transmembrane Helix Count 7

Publications:

RussLampel: ENSG00000158748

Alternate Names: HTR6 Display Id ENSG00000158748 Ensembl Gene Id 5-HYDROXYTRYPTAMINE 6 RECEPTOR (5-HT-6) (SEROTONIN RECEPTOR 6). [SOURCE:UNIPROT/SWISSPROT;ACC:P50406] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P50406

Alternate Names: HTR6 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

HopkinsGroom: P50406

Alternate Names: P50406 Uniprot Accession ENSG00000158748 Ensembl Gene Id 3362 Entrez Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Type Family Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

PharmGKB: HTR6

Alternate Names: PA29560 PharmGKB ID

Gene Info:

Publications: Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J

TTD: 5-HT 6 receptor

Alternate Names: HTR6 TTD Gene Abbreviation T16691 TTD Target ID

Gene Info:

DTC: HTR6

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

Direct Interaction yes

PMIDs:
24878269 23607787

Sources:
DTC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SUVN-502

Novel drug target Established target

PMIDs:
24900216

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
22355260

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 6 (5-HT6) receptor antagonist

Direct Interaction yes

Trial Name Lu-AE58054 , LY-483518, SGS518

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
11888555 19506838

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919 25032030

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
19997080

Sources:
PharmGKB

Alternate Names:

HTR6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P50406 Uniprot Accession

3362 Entrez Gene Id

5HT6R_HUMAN Uniprot Id

Gene Info:

Target Subclass Rhodopsin

Target Subclass GPCR

Transmembrane Helix Count 7

Alternate Names:

HTR6 Display Id

ENSG00000158748 Ensembl Gene Id

5-HYDROXYTRYPTAMINE 6 RECEPTOR (5-HT-6) (SEROTONIN RECEPTOR 6). [SOURCE:UNIPROT/SWISSPROT;ACC:P50406] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HTR6 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

P50406 Uniprot Accession

ENSG00000158748 Ensembl Gene Id

3362 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Family

Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

PA29560 PharmGKB ID

Publications:

Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J

Alternate Names:

HTR6 TTD Gene Abbreviation

T16691 TTD Target ID

Publications:

Krogsgaard-Larsen N et al., 2014, Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands., J Med Chem

Alternate Names:

HTR6 GENE_SYMBOL

5-hydroxytryptamine receptor 6 UNIPROT

Serotonin receptor 6 UNIPROT

Alternate Names:

ENSG00000158748 Gene Symbol

HTR6 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3362 Gene ID

5-HT6 dGene Synonym

5-HT6R dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR