IDH2 Gene Record

  • ENASIDENIB   IDH2

    Interaction Score: 41.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Indication/Tumor Type acute myeloid leukemia
    Response Type sensitive
    Approval Status FDA approved

    PMIDs:
    28588020 28193778 27721426


    Sources:
    JAX-CKB CIViC PharmGKB FDA OncoKB

  • VENETOCLAX   IDH2

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type acute myeloid leukemia
    Response Type predicted – sensitive
    Approval Status Phase II

    PMIDs:
    27520294 30725494


    Sources:
    JAX-CKB CIViC PharmGKB FDA

  • SARACATINIB   IDH2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type intrahepatic cholangiocarcinoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    27231123


    Sources:
    JAX-CKB

  • QUIZARTINIB   IDH2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Enasidenib + Quizartinib
    Indication/Tumor Type acute myeloid leukemia
    Response Type predicted – sensitive

    PMIDs:
    None found


    Sources:
    JAX-CKB

  • OLAPARIB   IDH2

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28148839


    Sources:
    CIViC

  • DASATINIB   IDH2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type intrahepatic cholangiocarcinoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    27231123


    Sources:
    JAX-CKB