DGIdb - IFNAR1 Gene Record

IFNAR1 3454 Druggable Genome

Alternate Names:

3454
INTERFERON ALPHA AND BETA RECEPTOR SUBUNIT 1
IFNAR1
AVP
IFN-alpha-REC
IFNAR
IFNBR
IFRC
107450
5432
ENSG00000142166
OTTHUMG00000065126
P17181
Type I interferon receptor 1
CRF2-1
IFN-alpha/beta receptor 1
Interferon alpha/beta receptor 1
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
IFN-R-1
INAR1_HUMAN
P48551
IFNAR2
T95371

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 2 cytokine receptor
Target Subclass	CytokineR
Transmembrane Helix Count	1
Target Subclass	IG
Target Main Class	Receptors
Target Subclass	Type2
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Khine et al., 2000, Functional significance of globotriaosyl ceramide in interferon-alpha(2)/type 1 interferon receptor-mediated antiviral activity., J. Cell. Physiol.
Dhalluin et al., Structural, kinetic, and thermodynamic analysis of the binding of the 40 kDa PEG-interferon-alpha2a and its individual positional isomers to the extracellular domain of the receptor IFNAR2., Bioconjug. Chem.
Ishii et al., 2010, Interferon alpha receptor 2 expression by peripheral blood monocytes in patients with a high viral load of hepatitis C virus genotype 1 showing substitution of amino Acid 70 in the core region., Intervirology

INTERFERON ALFA-N3 IFNAR1

Interaction Score: 15.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interferon alpha/beta receptor agonist

PMIDs:
15898717 11752352 17139284 17016423 19955815

Sources:
ChemblInteractions
INTERFERON ALFA-2B IFNAR1

Interaction Score: 12.88

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
17016423 17139284 11752352 10567921

Sources:
ChemblInteractions
INTERFERON ALFA-2A IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEGINTERFERON BETA-1A IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEGINTERFERON ALFA-2B IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interferon alpha/beta receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INTERFERON BETA-1A IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SIFALIMUMAB IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name sifalimumab, MEDI-545, MDX-1103

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PEGINTERFERON ALFA-2A IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALBINTERFERON ALFA-2B IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANIFROLUMAB IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
INTERFERON ALFACON-1 IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INTERFERON BETA-1B IFNAR1

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000142166
- Version: 101_38
Alternate Names:

IFNAR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P17181
- Version: 01-August-2011
Alternate Names:

ENSG00000142166 Ensembl Gene Id

3454 Entrez Gene Id

INAR1_HUMAN Uniprot Id

Gene Info:

Target Subclass CytokineR

Transmembrane Helix Count 1

Target Subclass IG

Publications:
TdgClinicalTrial: P48551
- Version: January-2014
Alternate Names:

IFNAR2 Gene Symbol

IFNAR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 2 cytokine receptor

Publications:
TdgClinicalTrial: P17181
- Version: January-2014
Alternate Names:

IFNAR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 2 cytokine receptor

Publications:
HingoraniCasas: ENSG00000142166
- Version: 31-May-2017
Alternate Names:

ENSG00000142166 Gene Symbol

IFNAR1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IFNAR
- Version: chembl_23
Alternate Names:

IFNAR GENE_SYMBOL

IFNAR1 GENE_SYMBOL

Interferon alpha/beta receptor 1 UNIPROT

Gene Info:

Publications:
Tempus: IFNAR1
- Version: 11-November-2018
Alternate Names:

IFNAR1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Interferon alpha/beta receptor 1
- Version: 2020.06.01
Alternate Names:

IFNAR1 TTD Gene Abbreviation

T95371 TTD Target ID

Gene Info:

Publications:
Pharos: IFNAR1
- Version: 01-February-2022
Alternate Names:

Interferon alpha/beta receptor 1 Gene Name

P17181 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Interferon alpha/beta receptor agonist

Trial Name	sifalimumab, MEDI-545, MDX-1103
Novel drug target	Established target

ENSG00000142166	Ensembl Gene Id
3454	Entrez Gene Id
INAR1_HUMAN	Uniprot Id

IFNAR	GENE_SYMBOL
IFNAR1	GENE_SYMBOL
Interferon alpha/beta receptor 1	UNIPROT

agonist (activating)
binder

IFNAR1 Gene Record

IFNAR1 3454 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Interferon alpha/beta receptor agonist

PMIDs: 15898717 11752352 17139284 17016423 19955815

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating) binder

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: 17016423 17139284 11752352 10567921

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Interferon alpha/beta receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name sifalimumab, MEDI-545, MDX-1103 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interferon alpha/beta receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000142166

Alternate Names: IFNAR1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P17181

Alternate Names: ENSG00000142166 Ensembl Gene Id 3454 Entrez Gene Id INAR1_HUMAN Uniprot Id

Gene Info: Target Subclass CytokineR Transmembrane Helix Count 1 Target Subclass IG

Publications:

TdgClinicalTrial: P48551

Alternate Names: IFNAR2 Gene Symbol IFNAR1 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 2 cytokine receptor

Publications:

TdgClinicalTrial: P17181

Alternate Names: IFNAR1 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 2 cytokine receptor

Publications:

HingoraniCasas: ENSG00000142166

Alternate Names: ENSG00000142166 Gene Symbol IFNAR1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: IFNAR

Alternate Names: IFNAR GENE_SYMBOL IFNAR1 GENE_SYMBOL Interferon alpha/beta receptor 1 UNIPROT

Gene Info:

Publications:

Tempus: IFNAR1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interferon alpha/beta receptor agonist

PMIDs:
15898717 11752352 17139284 17016423 19955815

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
17016423 17139284 11752352 10567921

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interferon alpha/beta receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name sifalimumab, MEDI-545, MDX-1103

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interferon alpha/beta receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

IFNAR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000142166 Ensembl Gene Id

3454 Entrez Gene Id

INAR1_HUMAN Uniprot Id

Gene Info:

Target Subclass CytokineR

Transmembrane Helix Count 1

Target Subclass IG

Alternate Names:

IFNAR2 Gene Symbol

IFNAR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 2 cytokine receptor

Alternate Names:

IFNAR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 2 cytokine receptor

Alternate Names:

ENSG00000142166 Gene Symbol

IFNAR1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IFNAR GENE_SYMBOL

IFNAR1 GENE_SYMBOL

Interferon alpha/beta receptor 1 UNIPROT

Alternate Names:

IFNAR1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

IFNAR1 TTD Gene Abbreviation

T95371 TTD Target ID

Alternate Names:

Interferon alpha/beta receptor 1 Gene Name

P17181 UniProt ID

Gene Categories:

KINASE