3480 |
INSULIN LIKE GROWTH FACTOR 1 RECEPTOR |
IGF1R |
CD221 |
IGFIR |
IGFR |
JTK13 |
147370 |
5465 |
ENSG00000140443 |
OTTHUMG00000149851 |
P08069 |
IGF-1R |
Insulin-like growth factor I receptor |
IGF1R_HUMAN |
INSULIN-LIKE GROWTH FACTOR I RECEPTOR PRECURSOR (EC 2.7.1.112) (CD221 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08069] |
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR ALPHA CHAIN |
IGF-I receptor |
CD_antigen=CD221 |
Insulin-like growth factor 1 receptor beta chain |
Insulin-like growth factor 1 receptor |
T48069 |
Target Subclass | Kinase |
Transmembrane Helix Count | 1 |
Target Subclass | InsR |
Target Main Class | Receptors |
Human Readable Name | DRUGGABLE GENOME |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | KINASE |
Uniprot Status | Swiss-Prot |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Interpro Acc | IPR001245 |
Interpro Type | Domain |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
CancerCommons Reported Gene Name | IGF1 Receptor |
CancerCommons Reported Gene Name | IGF1R |
CancerCommons Reported Gene Name | IGF1-R |
Gene Biotype | PROTEIN_CODING |
KINASE |
TYROSINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
agonist (activating) |
Mechanism of Interaction | Insulin-like growth factor I receptor agonist |
Direct Interaction | yes |
Trial Name | mecasermin, rhIGF-1,Increlex |
antibody (inhibitory) |
antagonist (inhibitory) |
Trial Name | dalotuzumab, MK-0646 |
Novel drug target | Established target |
Notes |
antibody (inhibitory) |
antagonist (inhibitory) |
Notes | |
Mechanism of Interaction | Insulin-like growth factor I receptor antagonist |
Direct Interaction | yes |
antibody (inhibitory) |
antagonist (inhibitory) |
Trial Name | cixutumumab, IMC-A12 |
Novel drug target | Established target |
Reported Cancer Type | Prostate |
inhibitor (inhibitory) |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
Direct Interaction | yes |
antibody (inhibitory) |
antagonist (inhibitory) |
Notes | |
Mechanism of Interaction | Insulin-like growth factor I receptor antagonist |
Direct Interaction | yes |
antibody (inhibitory) |
antagonist (inhibitory) |
Notes | |
Novel drug target | Established target |
Trial Name | AMG-479 |
antagonist (inhibitory) |
Mechanism of Interaction | Insulin-like growth factor I receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Insulin-like growth factor I receptor agonist |
inhibitor (inhibitory) |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
Direct Interaction | yes |
Trial Name | INSM-18 |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
inhibitor (inhibitory) |
Trial Name | OSI-906 |
Novel drug target | Established target |
Notes |
antibody (inhibitory) |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Insulin-like growth factor I receptor antagonist |
inhibitor (inhibitory) |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
Direct Interaction | yes |
antibody (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Insulin-like growth factor I receptor inhibitor |
Direct Interaction | yes |
IGF1R | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000140443 | Ensembl Gene Id |
P08069 | Uniprot Accession |
IGF1R_HUMAN | Uniprot Id |
Target Subclass | Kinase |
Transmembrane Helix Count | 1 |
Target Subclass | InsR |
IGF1R | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
3480 | Entrez Gene ID |
CancerCommons Reported Gene Name | IGF1 Receptor |
CancerCommons Reported Gene Name | IGF1R |
CancerCommons Reported Gene Name | IGF1-R |
3480 | Entrez Gene Id |
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR ALPHA CHAIN | Uniprot Protein Name |
ENSG00000140443 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Uniprot Evidence | 1: Evidence at protein level |
KINASE, DRUGGABLE GENOME |
INSULIN-LIKE GROWTH FACTOR I RECEPTOR PRECURSOR (EC 2.7.1.112) (CD221 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08069] | Description |
ENSG00000140443 | Ensembl Gene Id |
IGF1R | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
IGF-1R | Gene Symbol |
IGF1R | GENE_SYMBOL |
Insulin-like growth factor 1 receptor | UNIPROT |
Insulin-like growth factor 1 receptor alpha chain | UNIPROT |
3480 | Entrez Gene Id |
IGF1R | MyCancerGenome Gene Symbol |
IGF-1R | MyCancerGenome Reported Gene Name |
ENSG00000140443 | Gene Symbol |
IGF1R | Ensembl Id |
DRUGGABLE GENOME |
3480 | Gene ID |
CD221 | dGene Synonym |
IGFIR | dGene Synonym |
KINASE, TYROSINE KINASE |
IGF1R | TTD Gene Abbreviation |
T48069 | TTD Target ID |
Insulin-like growth factor 1 receptor | Gene Name |
P08069 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
TYROSINE KINASE |
CLINICALLY ACTIONABLE |