• Interaction Score: 8.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor agonist
    Direct Interaction yes
    Trial Name mecasermin, rhIGF-1,Increlex

  • Interaction Score: 6.68

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name dalotuzumab, MK-0646
    Novel drug target Established target
    Notes

  • Interaction Score: 6.68

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Insulin-like growth factor I receptor antagonist
    Direct Interaction yes

  • Interaction Score: 5.01

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name cixutumumab, IMC-A12
    Novel drug target Established target
    Reported Cancer Type Prostate

  • Interaction Score: 3.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 3.34

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Insulin-like growth factor I receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 3.34

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Novel drug target Established target
    Trial Name AMG-479

  • Interaction Score: 1.67

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin-like growth factor I receptor agonist

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor
    Direct Interaction yes
    Trial Name INSM-18

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor

    PMIDs:
    None found


  • Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name OSI-906
    Novel drug target Established target
    Notes

  • Interaction Score: 1.11

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin-like growth factor I receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.56

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.56

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor
    Direct Interaction yes
    Notes

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Insulin-like growth factor I receptor inhibitor
    Direct Interaction yes

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23837797


    Sources:
    DTC

  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12485928


    Sources:
    NCI

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7499260 11375274


    Sources:
    NCI

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8895768


    Sources:
    NCI

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14533013


    Sources:
    NCI

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC