DGIdb - IL1A Gene Record

IL1A 3552 Druggable Genome

Alternate Names:

3552
INTERLEUKIN 1 ALPHA
IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
147760
5991
ENSG00000115008
OTTHUMG00000131315
Interleukin-1 alpha
IL-1 alpha
Hematopoietin-1
P01583
IL1A_HUMAN
PA29807
T16340

Gene Info:

Target Class	Miscellaneous
Target Subclass	Ligand
Target Subclass	Cytokine
Target Main Class	Other
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Tran et al., 2013, Role of interleukin-1 inhibitors in the management of gout., Pharmacotherapy
Cronstein et al., 2013, Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis., J Clin Rheumatol
Sperber et al., 1993, Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells., J. Rheumatol.
McClay JL et al., 2011, Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia., Neuropsychopharmacology

BERMEKIMAB IL1A

Interaction Score: 20.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
RILONACEPT IL1A

Interaction Score: 20.61

Interaction Types & Directionality:

binder

Interaction Info:

Trial Name interleukin-1 (IL-1) trap

Novel drug target Established target

PMIDs:
23553601 23319019

Sources:
TdgClinicalTrial TEND
MABP1 IL1A

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMG-108 IL1A

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AMG-108

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
HYDROXYCHLOROQUINE IL1A

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8336306

Sources:
NCI
OLANZAPINE IL1A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21107309

Sources:
PharmGKB

Ensembl: ENSG00000115008
- Version: 101_38
Alternate Names:

IL1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P01583
- Version: January-2014
Alternate Names:

IL1A Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Cytokine

Publications:
TEND: P01583
- Version: 01-August-2011
Alternate Names:

ENSG00000115008 Ensembl Gene Id

IL1A Gene Symbol

IL1A_HUMAN Uniprot Id

Gene Info:

Target Subclass Ligand

Target Main Class Other

Target Subclass Cytokine

Publications:
PharmGKB: IL1A
- Version: 18-August-2020
Alternate Names:

PA29807 PharmGKB ID

Gene Info:

Publications:

McClay JL et al., 2011, Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia., Neuropsychopharmacology

NCI: IL1A

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Keicho et al., 1991, Effects of an immunosuppressant, FK506, on interleukin 1 alpha production by human macrophages and a macrophage-like cell line, U937., Cell. Immunol.

Mallardo et al., 1994, DNA damaging agents increase the stability of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 transcripts and the production of the relative proteins., J. Biol. Chem.

Sperber et al., 1993, Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells., J. Rheumatol.

ChemblInteractions: IL1F1
- Version: chembl_23
Alternate Names:

IL1F1 GENE_SYMBOL

IL1A GENE_SYMBOL

Interleukin-1 alpha UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000115008
- Version: 31-May-2017
Alternate Names:

ENSG00000115008 Gene Symbol

IL1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: IL1A
- Version: 01-February-2022
Alternate Names:

IL1F1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Interleukin-1 alpha
- Version: 2020.06.01
Alternate Names:

IL1A TTD Gene Abbreviation

T16340 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Interleukin-1 alpha inhibitor
Direct Interaction	yes

Trial Name	interleukin-1 (IL-1) trap
Novel drug target	Established target

ENSG00000115008	Ensembl Gene Id
IL1A	Gene Symbol
IL1A_HUMAN	Uniprot Id

IL1A Gene Record

IL1A 3552 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

BERMEKIMAB IL1A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-1 alpha inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

RILONACEPT IL1A

Interaction Types & Directionality: binder

Interaction Info: Trial Name interleukin-1 (IL-1) trap Novel drug target Established target

PMIDs: 23553601 23319019

Sources: TdgClinicalTrial TEND

MABP1 IL1A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

AMG-108 IL1A

Interaction Types & Directionality: n/a

Interaction Info: Trial Name AMG-108 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

HYDROXYCHLOROQUINE IL1A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8336306

Sources: NCI

OLANZAPINE IL1A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21107309

Sources: PharmGKB

Ensembl: ENSG00000115008

Alternate Names: IL1A Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P01583

Alternate Names: IL1A Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Ligand Target Subclass Cytokine

Publications:

TEND: P01583

Alternate Names: ENSG00000115008 Ensembl Gene Id IL1A Gene Symbol IL1A_HUMAN Uniprot Id

Gene Info: Target Subclass Ligand Target Main Class Other Target Subclass Cytokine

Publications:

PharmGKB: IL1A

Alternate Names: PA29807 PharmGKB ID

Gene Info:

Publications: McClay JL et al., 2011, Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia., Neuropsychopharmacology

NCI: IL1A

Alternate Names:

Gene Info:

ChemblInteractions: IL1F1

Alternate Names: IL1F1 GENE_SYMBOL IL1A GENE_SYMBOL Interleukin-1 alpha UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000115008

Alternate Names: ENSG00000115008 Gene Symbol IL1A Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: IL1A

Alternate Names: IL1F1 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

TTD: Interleukin-1 alpha

Alternate Names: IL1A TTD Gene Abbreviation T16340 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

binder

Interaction Info:

Trial Name interleukin-1 (IL-1) trap

Novel drug target Established target

PMIDs:
23553601 23319019

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AMG-108

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
8336306

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21107309

Sources:
PharmGKB

Alternate Names:

IL1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

IL1A Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Cytokine

Alternate Names:

ENSG00000115008 Ensembl Gene Id

IL1A Gene Symbol

IL1A_HUMAN Uniprot Id

Gene Info:

Target Subclass Ligand

Target Main Class Other

Target Subclass Cytokine

Alternate Names:

PA29807 PharmGKB ID

Publications:

McClay JL et al., 2011, Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia., Neuropsychopharmacology

Alternate Names:

IL1F1 GENE_SYMBOL

IL1A GENE_SYMBOL

Interleukin-1 alpha UNIPROT

Alternate Names:

ENSG00000115008 Gene Symbol

IL1A Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IL1F1 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

IL1A TTD Gene Abbreviation

T16340 TTD Target ID