DGIdb - IL4R Gene Record

IL4R 3566 Druggable Genome

Alternate Names:

3566
INTERLEUKIN 4 RECEPTOR
IL4R
CD124
IL-4RA
IL4RA
147781
6015
ENSG00000077238
OTTHUMG00000097015
IL-4 receptor subunit alpha
IL-4R-alpha
sIL4Ralpha/prot
Soluble IL-4R-alpha
Soluble IL-4 receptor subunit alpha
Interleukin-4 receptor subunit alpha
Soluble interleukin-4 receptor subunit alpha
CD_antigen=CD124
IL-4-binding protein
IL4-BP
IL-4R subunit alpha
P24394
PA29832
Interleukin 4 receptor alpha
T03346
582J2.1

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Wenzel S et al., 2013, Dupilumab in persistent asthma with elevated eosinophil levels., N Engl J Med

DUPILUMAB IL4R

Interaction Score: 37.1

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-4 receptor subunit alpha antagonist

Direct Interaction yes

PMIDs:
23688323

Sources:
ChemblInteractions TTD
PRX-321 IL4R

Interaction Score: 24.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PRX-321

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
PITRAKINRA IL4R

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CINTREDEKIN BESUDOTOX IL4R

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Interleukin-13 receptor subunit alpha-1, Interleukin-4 receptor subunit alpha binding agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROMILKIMAB IL4R

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000077238
- Version: 101_38
Alternate Names:

IL4R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P24394
- Version: January-2014
Alternate Names:

IL4RA Gene Symbol

IL4R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
PharmGKB: IL4R
- Version: 18-August-2020
Alternate Names:

PA29832 PharmGKB ID

Gene Info:

Publications:

Chen J et al., 2011, Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine., Vaccine
HingoraniCasas: ENSG00000077238
- Version: 31-May-2017
Alternate Names:

ENSG00000077238 Gene Symbol

IL4R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IL4RA
- Version: chembl_23
Alternate Names:

IL4RA GENE_SYMBOL

IL4R GENE_SYMBOL

Interleukin-4 receptor subunit alpha UNIPROT

Gene Info:

Publications:
GO: IL4R
- Version: 01-February-2022
Alternate Names:

IL4RA GO Gene Synonym

582J2.1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Interleukin 4 receptor alpha
- Version: 2020.06.01
Alternate Names:

IL4R TTD Gene Abbreviation

T03346 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Interleukin-4 receptor subunit alpha antagonist
Direct Interaction	yes

Mechanism of Interaction	Interleukin-13 receptor subunit alpha-1, Interleukin-4 receptor subunit alpha binding agent
Direct Interaction	yes

IL4RA	GENE_SYMBOL
IL4R	GENE_SYMBOL
Interleukin-4 receptor subunit alpha	UNIPROT

antibody (inhibitory)
antagonist (inhibitory)

Trial Name	PRX-321
Novel drug target	Novel Target

IL4R Gene Record

IL4R 3566 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DUPILUMAB IL4R

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-4 receptor subunit alpha antagonist Direct Interaction yes

PMIDs: 23688323

Sources: ChemblInteractions TTD

PRX-321 IL4R

Interaction Types & Directionality: n/a

Interaction Info: Trial Name PRX-321 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

PITRAKINRA IL4R

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

CINTREDEKIN BESUDOTOX IL4R

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Interleukin-13 receptor subunit alpha-1, Interleukin-4 receptor subunit alpha binding agent Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ROMILKIMAB IL4R

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000077238

Alternate Names: IL4R Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P24394

Alternate Names: IL4RA Gene Symbol IL4R Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

PharmGKB: IL4R

Alternate Names: PA29832 PharmGKB ID

Gene Info:

Publications: Chen J et al., 2011, Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine., Vaccine

HingoraniCasas: ENSG00000077238

Alternate Names: ENSG00000077238 Gene Symbol IL4R Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: IL4RA

Alternate Names: IL4RA GENE_SYMBOL IL4R GENE_SYMBOL Interleukin-4 receptor subunit alpha UNIPROT

Gene Info:

Publications:

GO: IL4R

Alternate Names: IL4RA GO Gene Synonym 582J2.1 GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Interleukin 4 receptor alpha

Alternate Names: IL4R TTD Gene Abbreviation T03346 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-4 receptor subunit alpha antagonist

Direct Interaction yes

PMIDs:
23688323

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PRX-321

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Interleukin-13 receptor subunit alpha-1, Interleukin-4 receptor subunit alpha binding agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

IL4R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

IL4RA Gene Symbol

IL4R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

PA29832 PharmGKB ID

Publications:

Chen J et al., 2011, Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine., Vaccine

Alternate Names:

ENSG00000077238 Gene Symbol

IL4R Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IL4RA GENE_SYMBOL

IL4R GENE_SYMBOL

Interleukin-4 receptor subunit alpha UNIPROT

Alternate Names:

IL4RA GO Gene Synonym

582J2.1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

IL4R TTD Gene Abbreviation

T03346 TTD Target ID