3674 |
INTEGRIN SUBUNIT ALPHA 2B |
ITGA2B |
BDPLT16 |
BDPLT2 |
CD41 |
CD41B |
GP2B |
GPIIb |
GT |
GTA |
HPA3 |
PPP1R93 |
607759 |
6138 |
ENSG00000005961 |
OTTHUMG00000177935 |
PA29938 |
CD_antigen=CD41 |
Integrin alpha-IIb light chain, form 1 |
Integrin alpha-IIb heavy chain |
Integrin alpha-IIb light chain, form 2 |
Integrin alpha-IIb |
GPalpha IIb |
ITGAB |
Platelet membrane glycoprotein IIb |
ITA2B_HUMAN |
P08514 |
INTEGRIN ALPHA-IIB PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIB) (GPALPHA IIB) (GPIIB) (CD41 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08514] |
GT1 |
Target Class | Receptors |
Target Subclass | Receptors |
Target Subclass | Integrin |
Target Main Class | Receptors |
Transmembrane Helix Count | 1 |
Target Subclass | Other_receptors |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000413 |
Interpro Name | Integrin alpha chain |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Integrin_alpha |
Interpro Type | Family |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
EXTERNAL SIDE OF PLASMA MEMBRANE |
DRUGGABLE GENOME |
antibody (inhibitory) |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Integrin alpha-IIb/beta-3 inhibitor |
Direct Interaction | yes |
Trial Name | abciximab, c7E3,ReoPro |
inhibitor (inhibitory) |
Trial Name | eptifibatide,Integrilin |
Novel drug target | Established target |
Mechanism of Interaction | Integrin alpha-IIb/beta-3 inhibitor |
n/a |
Trial Name | YM-028, gantofiban |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Integrin alpha-IIb/beta-3 antagonist |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Integrin alpha-IIb/beta-3 inhibitor |
Direct Interaction | yes |
ITGA2B | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ITGA2B | Display Id |
ENSG00000005961 | Ensembl Gene Id |
INTEGRIN ALPHA-IIB PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIB) (GPALPHA IIB) (GPIIB) (CD41 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08514] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ITGA2B | Uniprot Gene Name |
P08514 | Uniprot Accession |
INTEGRIN ALPHA-IIB LIGHT CHAIN, FORM 1 | Uniprot Protein Name |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000413 |
Interpro Name | Integrin alpha chain |
DRUGGABLE GENOME |
3674 | Entrez Gene Id |
ITA2B_HUMAN | Uniprot Id |
ITGA2B | Gene Symbol |
Target Subclass | Integrin |
Target Main Class | Receptors |
Transmembrane Helix Count | 1 |
ITGA2B | Gene Symbol |
Target Class | Receptors |
Target Subclass | Receptors |
Target Subclass | Integrin |
PA29938 | PharmGKB ID |
ENSG00000005961 | Gene Symbol |
ITGA2B | Ensembl Id |
DRUGGABLE GENOME |
ITGAB | GENE_SYMBOL |
ITGA2B | GENE_SYMBOL |
Integrin alpha-IIb | UNIPROT |
GP2B | GO Gene Synonym |
ITGAB | GO Gene Synonym |
CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE |