DGIdb - ITGA5 Gene Record

ITGA5 3678 Druggable Genome

Alternate Names:

3678
INTEGRIN SUBUNIT ALPHA 5
ITGA5
CD49e
FNRA
VLA-5
VLA5A
135620
6141
ENSG00000161638
OTTHUMG00000169841
INTEGRIN ALPHA-5 PRECURSOR (FIBRONECTIN RECEPTOR ALPHA SUBUNIT) (INTEGRIN ALPHA-F) (VLA-5) (CD49E). [SOURCE:UNIPROT/SWISSPROT;ACC:P08648]
INTEGRIN ALPHA-5 HEAVY CHAIN
FIBRONECTIN RECEPTOR SUBUNIT ALPHA
INTEGRIN ALPHA-5
P08648
INTEGRIN ALPHA-F
INTEGRIN ALPHA-5 LIGHT CHAIN
CD_antigen=CD49e
CD49 antigen-like family member E
ITA5_HUMAN
T29879

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	Receptors
Target Subclass	Integrin
Interpro Acc	IPR000413
Interpro Name	Integrin alpha chain
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Short Name	Integrin_alpha
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Kremlev et al., 1998, CSF-1 (M-CSF) enhances the inflammatory response of fibronectin-primed macrophages: pathways involved in activation of the cytokine network., Nat. Immun.
Trayner et al., 1998, Changes in antigen expression on differentiating HL60 cells treated with dimethylsulphoxide, all-trans retinoic acid, alpha1,25-dihydroxyvitamin D3 or 12-O-tetradecanoyl phorbol-13-acetate., Leuk. Res.

CILMOSTIM ITGA5

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11061591

Sources:
NCI
VOLOCIXIMAB ITGA5

Interaction Score: 5.89

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-5/beta-1 antagonist

Direct Interaction yes

Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs:
None found

Sources:
TALC ChemblInteractions
PF-04605412 ITGA5

Interaction Score: 4.42

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs:
None found

Sources:
TALC
DIMETHYL SULFOXIDE ITGA5

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9678720

Sources:
NCI
ETARACIZUMAB ITGA5

Interaction Score: 2.21

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs:
None found

Sources:
TALC
CILENGITIDE ITGA5

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name cilengitide. EMD-121974

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
GLPG-0187 ITGA5

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name GLPG0187

PMIDs:
None found

Sources:
TdgClinicalTrial

Ensembl: ENSG00000161638
- Version: 101_38
Alternate Names:

ITGA5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P08648
- Version: January-2014
Alternate Names:

ITGA5 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Integrin

Publications:

RussLampel: ENSG00000161638

Version: 26-July-2011

Alternate Names:

INTEGRIN ALPHA-5 PRECURSOR (FIBRONECTIN RECEPTOR ALPHA SUBUNIT) (INTEGRIN ALPHA-F) (VLA-5) (CD49E). [SOURCE:UNIPROT/SWISSPROT;ACC:P08648] Description

ENSG00000161638 Ensembl Gene Id

ITGA5 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P08648
- Version: 11-September-2012
Alternate Names:

ITA5_HUMAN Uniprot Id

ITGA5 Uniprot Gene Name

P08648 Uniprot Accession

Gene Info:

Interpro Acc IPR000413

Interpro Name Integrin alpha chain

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: ITGA5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kremlev et al., 1998, CSF-1 (M-CSF) enhances the inflammatory response of fibronectin-primed macrophages: pathways involved in activation of the cytokine network., Nat. Immun.

Trayner et al., 1998, Changes in antigen expression on differentiating HL60 cells treated with dimethylsulphoxide, all-trans retinoic acid, alpha1,25-dihydroxyvitamin D3 or 12-O-tetradecanoyl phorbol-13-acetate., Leuk. Res.

TALC: ITGA5
- Version: 12-May-2016
Alternate Names:

ITGA5 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: FNRA
- Version: chembl_23
Alternate Names:

FNRA GENE_SYMBOL

ITGA5 GENE_SYMBOL

Integrin alpha-5 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000161638
- Version: 31-May-2017
Alternate Names:

ENSG00000161638 Gene Symbol

ITGA5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ITGA5
- Version: 01-February-2022
Alternate Names:

FNRA GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Integrin alpha-5
- Version: 2020.06.01
Alternate Names:

ITGA5 TTD Gene Abbreviation

T29879 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Integrin alpha-5/beta-1 antagonist
Direct Interaction	yes
Notes	Targets ALPHA-5/BETA-1 INTEGRIN

Trial Name	cilengitide. EMD-121974
Novel drug target	Novel Target

INTEGRIN ALPHA-5 PRECURSOR (FIBRONECTIN RECEPTOR ALPHA SUBUNIT) (INTEGRIN ALPHA-F) (VLA-5) (CD49E). [SOURCE:UNIPROT/SWISSPROT;ACC:P08648]	Description
ENSG00000161638	Ensembl Gene Id
ITGA5	Display Id

ITA5_HUMAN	Uniprot Id
ITGA5	Uniprot Gene Name
P08648	Uniprot Accession

antibody (inhibitory)
antagonist (inhibitory)

FNRA	GENE_SYMBOL
ITGA5	GENE_SYMBOL
Integrin alpha-5	UNIPROT

ITGA5 Gene Record

ITGA5 3678 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CILMOSTIM ITGA5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11061591

Sources: NCI

VOLOCIXIMAB ITGA5

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-5/beta-1 antagonist Direct Interaction yes Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs: None found

Sources: TALC ChemblInteractions

PF-04605412 ITGA5

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info: Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs: None found

Sources: TALC

DIMETHYL SULFOXIDE ITGA5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9678720

Sources: NCI

ETARACIZUMAB ITGA5

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info: Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs: None found

Sources: TALC

CILENGITIDE ITGA5

Interaction Types & Directionality: n/a

Interaction Info: Trial Name cilengitide. EMD-121974 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

GLPG-0187 ITGA5

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name GLPG0187

PMIDs: None found

Sources: TdgClinicalTrial

Ensembl: ENSG00000161638

Alternate Names: ITGA5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P08648

Alternate Names: ITGA5 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass Integrin

Publications:

RussLampel: ENSG00000161638

Alternate Names: INTEGRIN ALPHA-5 PRECURSOR (FIBRONECTIN RECEPTOR ALPHA SUBUNIT) (INTEGRIN ALPHA-F) (VLA-5) (CD49E). [SOURCE:UNIPROT/SWISSPROT;ACC:P08648] Description ENSG00000161638 Ensembl Gene Id ITGA5 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P08648

Alternate Names: ITA5_HUMAN Uniprot Id ITGA5 Uniprot Gene Name P08648 Uniprot Accession

Gene Info: Interpro Acc IPR000413 Interpro Name Integrin alpha chain Uniprot Evidence 1: Evidence at protein level

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: ITGA5

Alternate Names:

Gene Info:

TALC: ITGA5

Alternate Names: ITGA5 Gene Symbol

Gene Info:

Publications:

ChemblInteractions: FNRA

Alternate Names: FNRA GENE_SYMBOL ITGA5 GENE_SYMBOL Integrin alpha-5 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000161638

Alternate Names: ENSG00000161638 Gene Symbol ITGA5 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: ITGA5

Alternate Names: FNRA GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
11061591

Sources:
NCI

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-5/beta-1 antagonist

Direct Interaction yes

Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs:
None found

Sources:
TALC ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
9678720

Sources:
NCI

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Notes Targets ALPHA-5/BETA-1 INTEGRIN

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name cilengitide. EMD-121974

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name GLPG0187

PMIDs:
None found

Sources:
TdgClinicalTrial

Alternate Names:

ITGA5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ITGA5 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Integrin

Alternate Names:

INTEGRIN ALPHA-5 PRECURSOR (FIBRONECTIN RECEPTOR ALPHA SUBUNIT) (INTEGRIN ALPHA-F) (VLA-5) (CD49E). [SOURCE:UNIPROT/SWISSPROT;ACC:P08648] Description

ENSG00000161638 Ensembl Gene Id

ITGA5 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ITA5_HUMAN Uniprot Id

ITGA5 Uniprot Gene Name

P08648 Uniprot Accession

Gene Info:

Interpro Acc IPR000413

Interpro Name Integrin alpha chain

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ITGA5 Gene Symbol

Alternate Names:

FNRA GENE_SYMBOL

ITGA5 GENE_SYMBOL

Integrin alpha-5 UNIPROT

Alternate Names:

ENSG00000161638 Gene Symbol

ITGA5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FNRA GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

ITGA5 TTD Gene Abbreviation

T29879 TTD Target ID