3685 |
INTEGRIN SUBUNIT ALPHA V |
ITGAV |
CD51 |
MSK8 |
VNRA |
VTNR |
193210 |
6150 |
ENSG00000138448 |
OTTHUMG00000132635 |
P06756 |
ITAV_HUMAN |
INTEGRIN ALPHA-V LIGHT CHAIN |
INTEGRIN ALPHA-V PRECURSOR (VITRONECTIN RECEPTOR ALPHA SUBUNIT) (CD51 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06756] |
CD_antigen=CD51 |
Vitronectin receptor subunit alpha |
Integrin alpha-V heavy chain |
Integrin alpha-V |
T67103 |
Target Class | Receptors |
Target Subclass | Receptors |
Target Subclass | Integrin |
Interpro Name | Integrin alpha chain |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000413 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Integrin_alpha |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Family |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
EXTERNAL SIDE OF PLASMA MEMBRANE |
DRUGGABLE GENOME |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Integrin alpha-V/beta-3 antagonist |
Notes | Targets ALPHA-V/BETA-5 INTEGRIN |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Integrin alpha-V/beta-6 inhibitor |
antagonist (inhibitory) |
Trial Name | CNTO-95 |
Novel drug target | Established target |
Mechanism of Interaction | Integrin alpha-V/beta-1 antagonist |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Integrin alpha-V/beta-1 inhibitor |
n/a |
Novel drug target | Established target |
Trial Name | volociximab, E10030, Eos200-4 |
antibody (inhibitory) |
antagonist (inhibitory) |
Mechanism of Interaction | Integrin alpha-V/beta-3 antagonist |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Integrin alpha-V/beta-3 inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | GLPG0187 |
Novel drug target | Established target |
ITGAV | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
INTEGRIN ALPHA-V PRECURSOR (VITRONECTIN RECEPTOR ALPHA SUBUNIT) (CD51 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06756] | Description |
ITGAV | Display Id |
ENSG00000138448 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ITGAV | Gene Symbol |
Target Class | Receptors |
Target Subclass | Receptors |
Target Subclass | Integrin |
ENSG00000138448 | Ensembl Gene Id |
ITGAV | Uniprot Gene Name |
3685 | Entrez Gene Id |
Interpro Name | Integrin alpha chain |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR000413 |
DRUGGABLE GENOME |
ITGAV | Gene Symbol |
ENSG00000138448 | Gene Symbol |
ITGAV | Ensembl Id |
DRUGGABLE GENOME |
VNRA | GENE_SYMBOL |
ITGAV | GENE_SYMBOL |
Integrin alpha-V | UNIPROT |
MSK8 | GO Gene Synonym |
VNRA | GO Gene Synonym |
VTNR | GO Gene Synonym |
CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE |
ITGAV | TTD Gene Abbreviation |
T67103 | TTD Target ID |