ITGB1 Gene Record

  • ITGB1 3688 Druggable Genome

    Alternate Names:

    3688
    INTEGRIN SUBUNIT BETA 1
    ITGB1
    CD29
    FNRB
    GPIIA
    MDF2
    MSK12
    VLA-BETA
    VLAB
    135630
    6153
    ENSG00000150093
    OTTHUMG00000017928
    P05556
    ITB1_HUMAN
    INTEGRIN BETA-1
    INTEGRIN BETA-1 PRECURSOR (FIBRONECTIN RECEPTOR BETA SUBUNIT) (CD29 ANTIGEN) (INTEGRIN VLA-4 BETA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05556]
    CD_antigen=CD29
    VLA-4 subunit beta
    Glycoprotein IIa
    Fibronectin receptor subunit beta
    T01851

    Gene Info:

    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin
    Interpro Acc IPR002369
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Name Integrin beta subunit, N-terminal
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Integrin_bsu_N
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    TUMOR SUPPRESSOR
    KINASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

  • VOLOCIXIMAB   ITGB1

    Interaction Score: 6.87

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin alpha-5/beta-1 antagonist
    Notes Targets ALPHA-5/BETA-1 INTEGRIN

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • FIRATEGRAST   ITGB1

    Interaction Score: 4.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name SB-683699, T-0047
    Novel drug target Established target
    Mechanism of Interaction Integrin alpha-4/beta-1 antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PF-04605412   ITGB1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Notes Targets ALPHA-5/BETA-1 INTEGRIN

    PMIDs:
    None found


    Sources:
    TALC

  • SAN-300   ITGB1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SAN-300
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • NATALIZUMAB   ITGB1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin alpha-4/beta-1 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETARACIZUMAB   ITGB1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Notes Targets ALPHA-5/BETA-1 INTEGRIN

    PMIDs:
    None found


    Sources:
    TALC

  • INTETUMUMAB   ITGB1

    Interaction Score: 1.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-V/beta-1 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ABITUZUMAB   ITGB1

    Interaction Score: 1.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin alpha-V/beta-1 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GLPG-0187   ITGB1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GLPG0187
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000150093

    • Version: 101_38

    Alternate Names:
    ITGB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P05556

    • Version: January-2014

    Alternate Names:
    ITGB1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin

    Publications:

  • RussLampel: ENSG00000150093

    • Version: 26-July-2011

    Alternate Names:
    ITGB1 Display Id
    INTEGRIN BETA-1 PRECURSOR (FIBRONECTIN RECEPTOR BETA SUBUNIT) (CD29 ANTIGEN) (INTEGRIN VLA-4 BETA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P05556] Description
    ENSG00000150093 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P05556

    • Version: 11-September-2012

    Alternate Names:
    ITGB1 Uniprot Gene Name
    ENSG00000150093 Ensembl Gene Id
    ITB1_HUMAN Uniprot Id

    Gene Info:
    Interpro Acc IPR002369
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000150093

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000150093 Gene Symbol
    ITGB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: ITGB1

    • Version: 12-May-2016

    Alternate Names:
    ITGB1 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: FNRB

    • Version: chembl_23

    Alternate Names:
    MDF2 GENE_SYMBOL
    MSK12 GENE_SYMBOL
    ITGB1 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: ITGB1

    • Version: 01-February-2022

    Alternate Names:
    FNRB GO Gene Synonym
    MDF2 GO Gene Synonym
    MSK12 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TUMOR SUPPRESSOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Integrin beta-1

    • Version: 2020.06.01

    Alternate Names:
    ITGB1 TTD Gene Abbreviation
    T01851 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ITGB1

    • Version: 01-February-2022

    Alternate Names:
    Integrin beta-1 Gene Name
    P05556 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: