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JAK1 3716 Druggable GenomeClinically ActionableDrug Resistance
Alternate Names:
3716 JANUS KINASE 1 JAK1 JAK1A JAK1B JTK3 147795 6190 ENSG00000162434 OTTHUMG00000009310 P23458 Tyrosine-protein kinase JAK1 JAK-1 JAK1/2 JAK1_HUMAN 3090 TYROSINE-PROTEIN KINASE JAK1 (EC 2.7.1.112) (JANUS KINASE 1) (JAK-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23458] T62460 AIIDE Gene Info:
Interpro Type Domain Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Human Readable Name KINASE Human Readable Name DRUGGABLE GENOME Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Uniprot Status Swiss-Prot Interpro Acc IPR001245 Uniprot Evidence 1: Evidence at protein level Target Class Enzymes Target Subclass EC:2.7.10.2 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE TYROSINE KINASE DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE Publications:
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Interaction Score: 6.18
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 6.18
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 4.12
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor -
Interaction Score: 3.43
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Interaction Score: 3.09
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 3.09
-
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 2.06
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 1.85
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Janus Kinase (JAK) inhibitor Direct Interaction yes Novel drug target Novel Target -
Interaction Score: 1.55
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 1.55
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 1.55
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 1.55
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor -
Interaction Score: 1.24
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 1.03
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor Direct Interaction yes -
Interaction Score: 0.77
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Janus Kinase (JAK) inhibitor Direct Interaction yes -
Interaction Score: 0.77
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 0.56
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Interaction Score: 0.1
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- Version: 101_38
Alternate Names:
JAK1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 26-July-2011
Alternate Names:
TYROSINE-PROTEIN KINASE JAK1 (EC 2.7.1.112) (JANUS KINASE 1) (JAK-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23458] Description ENSG00000162434 Ensembl Gene Id JAK1 Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
JAK1 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.10.2 Publications:
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- Version: 11-September-2012
Alternate Names:
P23458 Uniprot Accession 3716 Entrez Gene Id JAK1 Uniprot Gene Name Gene Info:
Interpro Type Domain Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Human Readable Name KINASE Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
-
Alternate Names:
3716 Entrez Gene ID 3090 CIViC Gene ID Gene Info:
Gene Categories:
DRUG RESISTANCE Publications:
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Alternate Names:
Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000162434 Gene Symbol JAK1 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 20-Jun-2017
Alternate Names:
3716 Entrez Gene Id JAK1 MyCancerGenome Gene Symbol JAK1/2 MyCancerGenome Reported Gene Name Gene Info:
Publications:
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- Version: chembl_23
Alternate Names:
JAK1B GENE_SYMBOL JAK1 GENE_SYMBOL Tyrosine-protein kinase JAK1 UNIPROT Gene Info:
Publications:
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Alternate Names:
JAK1A GO Gene Synonym JAK1B GO Gene Synonym Gene Info:
Gene Categories:
TYROSINE KINASE Publications:
-
Alternate Names:
JAK1 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
3716 Gene ID JAK1A dGene Synonym JAK1B dGene Synonym Gene Info:
Gene Categories:
KINASE, TYROSINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
JAK-1 TTD Gene Abbreviation T62460 TTD Target ID Gene Info:
Publications:
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Alternate Names:
Tyrosine-protein kinase JAK1 Gene Name P23458 UniProt ID Gene Info:
Gene Categories:
KINASE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
DRUG RESISTANCE Publications: