DGIdb - JAK3 Gene Record

JAK3 3718 Druggable GenomeClinically Actionable

Alternate Names:

3718
JANUS KINASE 3
JAK3
JAK-3
JAK3_HUMAN
JAKL
L-JAK
LJAK
600173
6193
ENSG00000105639
OTTHUMG00000165648
3091
P52333
TYROSINE-PROTEIN KINASE JAK3
LEUKOCYTE JANUS KINASE
T23172

Gene Info:

Interpro Acc	IPR001245
Interpro Type	Domain
Human Readable Name	KINASE
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Tan L et al., 2015, Development of Selective Covalent Janus Kinase 3 Inhibitors., J Med Chem
Losdyck et al., 2015, Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities., J. Biol. Chem.
Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science
Koo et al., 2012, Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma., Cancer Discov
Elliott et al., 2011, FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma., Blood
Yin et al., 2015, Identification of mutant alleles of JAK3 in pediatric patients with acute lymphoblastic leukemia., Leuk. Lymphoma
Degryse et al., 2014, JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model., Blood
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Van Allen et al., 2015, Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation., Cancer Immunol Res

DECERNOTINIB JAK3

Interaction Score: 5.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name VX-509

Novel drug target Novel Target

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
TOFACITINIB JAK3

Interaction Score: 3.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical - Cell culture

PMIDs:
14593182 26258521 22705984 21821710 25146434 26446793 25193870 10592235

Sources:
DTC JAX-CKB CIViC TTD
TASOCITINIB JAK3

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Tasocitinib

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PF-06651600 JAK3

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
XELJANZ JAK3

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
R-348 JAK3

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions
WHI-P131 JAK3

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEFICITINIB JAK3

Interaction Score: 1.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

Trial Name ASP015K

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
TRICETAMIDE JAK3

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
R-333 JAK3

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUXOLITINIB JAK3

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Evidence Type Actionable

Indication/Tumor Type Advanced Solid Tumor

Response Type decreased response

PMIDs:
26258521 26446793

Sources:
DTC JAX-CKB
CERDULATINIB JAK3

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
TOFACITINIB CITRATE JAK3

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AT-9283 JAK3

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions
ATEZOLIZUMAB JAK3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26014096

Sources:
CIViC
LAUROGUADINE JAK3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ADAVOSERTIB JAK3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X JAK3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1997335 JAK3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 JAK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL379975 JAK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 JAK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 JAK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN JAK3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB JAK3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 JAK3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 JAK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 JAK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 JAK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 JAK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 JAK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB JAK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000105639
- Version: 101_38
Alternate Names:

JAK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P52333
- Version: 11-September-2012
Alternate Names:

JAK3 Uniprot Gene Name

JAK3_HUMAN Uniprot Id

ENSG00000105639 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Human Readable Name KINASE

Uniprot Status Swiss-Prot

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P52333
- Version: January-2014
Alternate Names:

JAK3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:

JAX-CKB: JAK3

Version: 27-September-2017

Alternate Names:

3718 CKB Entrez Id

JAK3 CKB Gene Synonym

JAK-3 CKB Gene Synonym

Gene Info:

Publications:

Sato et al., 2008, Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome., Br. J. Haematol.

Losdyck et al., 2015, Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities., J. Biol. Chem.

Koo et al., 2012, Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma., Cancer Discov

CIViC: JAK3

Version: 14-September-2020

Alternate Names:

3718 Entrez Gene ID

3091 CIViC Gene ID

Gene Info:

Publications:

Van Allen et al., 2015, Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation., Cancer Immunol Res

Degryse et al., 2014, JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model., Blood

DTC: JAK3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tan L et al., 2015, Development of Selective Covalent Janus Kinase 3 Inhibitors., J Med Chem

Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science

HingoraniCasas: ENSG00000105639
- Version: 31-May-2017
Alternate Names:

ENSG00000105639 Gene Symbol

JAK3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: JAK3
- Version: chembl_23
Alternate Names:

JAK3 GENE_SYMBOL

Tyrosine-protein kinase JAK3 UNIPROT

Janus kinase 3 UNIPROT

Gene Info:

Publications:
MyCancerGenome: JAK3
- Version: 20-Jun-2017
Alternate Names:

3718 Entrez Gene Id

JAK3 MyCancerGenome Gene Symbol

JAK3 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
TALC: JAK3
- Version: 12-May-2016
Alternate Names:

JAK3 Gene Symbol

Gene Info:

Publications:
Tempus: JAK3
- Version: 11-November-2018
Alternate Names:

JAK3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: JAK3
- Version: 27-Jun-2013
Alternate Names:

3718 Gene ID

JAK-3 dGene Synonym

JAK3_HUMAN dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Janus kinase 3
- Version: 2020.06.01
Alternate Names:

JAK-3 TTD Gene Abbreviation

T23172 TTD Target ID

Gene Info:

Publications:
Pharos: JAK3
- Version: 01-February-2022
Alternate Names:

Tyrosine-protein kinase JAK3 Gene Name

P52333 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: JAK3
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: JAK3
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: JAK3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: JAK3
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

TYROSINE KINASE

Publications:
Oncomine: JAK3
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Trial Name	VX-509
Novel drug target	Novel Target
Mechanism of Interaction	Tyrosine-protein kinase JAK3 inhibitor

Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive
Approval Status	Preclinical - Cell culture

Mechanism of Interaction	Tyrosine-protein kinase JAK3 inhibitor
Direct Interaction	yes

Mechanism of Interaction	Janus Kinase (JAK) inhibitor
Direct Interaction	yes
Trial Name	ASP015K

Evidence Type	Actionable
Indication/Tumor Type	Advanced Solid Tumor
Response Type	decreased response

JAK3	Uniprot Gene Name
JAK3_HUMAN	Uniprot Id
ENSG00000105639	Ensembl Gene Id

JAK3	GENE_SYMBOL
Tyrosine-protein kinase JAK3	UNIPROT
Janus kinase 3	UNIPROT

3718	Entrez Gene Id
JAK3	MyCancerGenome Gene Symbol
JAK3	MyCancerGenome Reported Gene Name

JAK3 Gene Record

JAK3 3718 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name VX-509 Novel drug target Novel Target Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Preclinical - Cell culture

PMIDs: 14593182 26258521 22705984 21821710 25146434 26446793 25193870 10592235

Sources: DTC JAX-CKB CIViC TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Tasocitinib Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor Direct Interaction yes

PMIDs: 10592235

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Janus Kinase (JAK) inhibitor Direct Interaction yes Trial Name ASP015K

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Evidence Type Actionable Indication/Tumor Type Advanced Solid Tumor Response Type decreased response

PMIDs: 26258521 26446793

Sources: DTC JAX-CKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Janus Kinase (JAK) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26014096

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name VX-509

Novel drug target Novel Target

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical - Cell culture

PMIDs:
14593182 26258521 22705984 21821710 25146434 26446793 25193870 10592235

Sources:
DTC JAX-CKB CIViC TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Tasocitinib

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

Trial Name ASP015K

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Evidence Type Actionable

Indication/Tumor Type Advanced Solid Tumor

Response Type decreased response

PMIDs:
26258521 26446793

Sources:
DTC JAX-CKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase JAK3 inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
26014096

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found