DGIdb - KCNA5 Gene Record

KCNA5 3741 Druggable Genome

Alternate Names:

3741
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5
KCNA5
ATFB7
HCK1
HK2
HPCN1
KV1.5
PCN1
176267
6224
ENSG00000130037
OTTHUMG00000168232
Voltage-gated potassium channel subunit Kv1.5
Voltage-gated potassium channel HK2
P22460
KCNA5_HUMAN
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460]
Voltage-gated potassium channel Kv1.5
T17569

Gene Info:

Initial Gene Query	Kv1.5
Counted Citations from 1950-2000	725
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ion_trans_dom
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	Ion transport domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Interpro Acc	IPR005821
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.
Judge et al., 2006, Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment., Pharmacol. Ther.
Yang et al., 1995, Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers., Br. J. Pharmacol.
Drici et al., 1996, Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart., Circulation

BMS-394136 KCNA5

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BMS-919373 KCNA5

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL178707 KCNA5

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TERFENADINE KCNA5

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7670728

Sources:
NCI
DRONEDARONE KCNA5

Interaction Score: 0.7

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
LORATADINE KCNA5

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9271355

Sources:
NCI
ANDROSTANOLONE KCNA5

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8823008

Sources:
NCI
DALFAMPRIDINE KCNA5

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
16472864

Sources:
ChemblInteractions
TEDISAMIL KCNA5

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GUANIDINE HYDROCHLORIDE KCNA5

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE KCNA5

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000130037
- Version: 101_38
Alternate Names:

KCNA5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000130037

Version: 26-July-2011

Alternate Names:

KCNA5 Display Id

ENSG00000130037 Ensembl Gene Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P22460
- Version: 11-September-2012
Alternate Names:

ENSG00000130037 Ensembl Gene Id

P22460 Uniprot Accession

KCNA5_HUMAN Uniprot Id

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
BaderLabGenes: KCNA5
- Version: February-2014
Alternate Names:

3741 Entrez Gene ID

Gene Info:

Initial Gene Query Kv1.5

Counted Citations from 1950-2000 725

Gene Categories:

ION CHANNEL

Publications:

NCI: KCNA5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Drici et al., 1996, Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart., Circulation

Nishiyama et al., 1997, Effects of thyroid and glucocorticoid hormones on Kv1.5 potassium channel gene expression in the rat left ventricle., Biochem. Biophys. Res. Commun.

Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.

ChemblInteractions: KCNA5
- Version: chembl_23
Alternate Names:

KCNA5 GENE_SYMBOL

Potassium voltage-gated channel subfamily A member 5 UNIPROT

HPCN1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000130037
- Version: 31-May-2017
Alternate Names:

ENSG00000130037 Gene Symbol

KCNA5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Voltage-gated potassium channel Kv1.5
- Version: 2020.06.01
Alternate Names:

KCNA5 TTD Gene Abbreviation

T17569 TTD Target ID

Gene Info:

Publications:
Pharos: KCNA5
- Version: 01-February-2022
Alternate Names:

Potassium voltage-gated channel subfamily A member 5 Gene Name

P22460 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
GO: KCNA5
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Mechanism of Interaction	Voltage-gated potassium channel blocker
Direct Interaction	yes

KCNA5	Display Id
ENSG00000130037	Ensembl Gene Id
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460]	Description

KCNA5	GENE_SYMBOL
Potassium voltage-gated channel subfamily A member 5	UNIPROT
HPCN1	UNIPROT

Potassium voltage-gated channel subfamily A member 5	Gene Name
P22460	UniProt ID

antagonist (inhibitory)
blocker (inhibitory)

KCNA5 Gene Record

KCNA5 3741 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7670728

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9271355

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8823008

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: 16472864

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000130037

Alternate Names: KCNA5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000130037

Alternate Names: KCNA5 Display Id ENSG00000130037 Ensembl Gene Id POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P22460

Alternate Names: ENSG00000130037 Ensembl Gene Id P22460 Uniprot Accession KCNA5_HUMAN Uniprot Id

Gene Info: Interpro Short Name Ion_trans_dom Interpro Type Domain Human Readable Name DRUGGABLE GENOME

Gene Categories: ION CHANNEL, DRUGGABLE GENOME

Publications:

BaderLabGenes: KCNA5

Alternate Names: 3741 Entrez Gene ID

Gene Info: Initial Gene Query Kv1.5 Counted Citations from 1950-2000 725

Gene Categories: ION CHANNEL

Publications:

NCI: KCNA5

Alternate Names:

Gene Info:

ChemblInteractions: KCNA5

Alternate Names: KCNA5 GENE_SYMBOL Potassium voltage-gated channel subfamily A member 5 UNIPROT HPCN1 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000130037

Alternate Names: ENSG00000130037 Gene Symbol KCNA5 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
7670728

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9271355

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8823008

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
16472864

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

KCNA5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

KCNA5 Display Id

ENSG00000130037 Ensembl Gene Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000130037 Ensembl Gene Id

P22460 Uniprot Accession

KCNA5_HUMAN Uniprot Id

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

3741 Entrez Gene ID

Gene Info:

Initial Gene Query Kv1.5

Counted Citations from 1950-2000 725

Gene Categories:

ION CHANNEL

Alternate Names:

KCNA5 GENE_SYMBOL

Potassium voltage-gated channel subfamily A member 5 UNIPROT

HPCN1 UNIPROT

Alternate Names:

ENSG00000130037 Gene Symbol

KCNA5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KCNA5 TTD Gene Abbreviation

T17569 TTD Target ID

Alternate Names:

Potassium voltage-gated channel subfamily A member 5 Gene Name

P22460 UniProt ID

Gene Categories:

ION CHANNEL

Gene Categories:

CELL SURFACE