3767 |
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 11 |
KCNJ11 |
BIR |
HHF2 |
IKATP |
KIR6.2 |
MODY13 |
PHHI |
TNDM3 |
600937 |
6257 |
ENSG00000187486 |
OTTHUMG00000165914 |
Q14654 |
IRK11_HUMAN |
POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525] |
NM_000525.3 |
PA217 |
Inward rectifier K(+) channel Kir6.2 |
ATP-sensitive inward rectifier potassium channel 11 |
Potassium channel, inwardly rectifying subfamily J member 11 |
potassium inwardly rectifying channel subfamily J member 11 |
PNDM2 |
Transmembrane Helix Count | 2 |
Target Subclass | Channels |
Target Main Class | Transporters |
Target Subclass | InwardlyRectifyingKchannel |
Target Subclass | Voltage_gated_ion_channels |
Human Readable Name | DRUGGABLE GENOME |
Initial Gene Query | Kir6.2 |
Counted Citations from 1950-2000 | 1209 |
Target Class | Transporters |
Target Subclass | TC:1.A.2.1 |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
blocker (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
Trial Name | glimepiride,Amaryl |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
inducer (activating) |
Trial Name | Levosimendan |
Novel drug target | Established target |
inducer (activating) |
Mechanism of Interaction | Potassium channel, inwardly rectifying, subfamily J, member 11 opener |
Direct Interaction | yes |
blocker (inhibitory) |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | Sulfonylurea receptors; K-ATP channels opener |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | Sulfonylurea receptors; K-ATP channels opener |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | Sulfonylurea receptor 2, Kir6.2 opener |
blocker (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
blocker (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
activator (activating) |
Mechanism of Interaction | Sulfonylurea receptor 2, Kir6.2 opener |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sulfonylurea receptor 1, Kir6.2 blocker |
Direct Interaction | yes |
KCNJ11 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000187486 | Ensembl Gene Id |
Q14654 | Uniprot Accession |
KCNJ11 | Gene Symbol |
Transmembrane Helix Count | 2 |
Target Subclass | Channels |
Target Main Class | Transporters |
POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525] | Description |
NM_000525.3 | Display Id |
ENSG00000187486 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
3767 | Entrez Gene ID |
Initial Gene Query | Kir6.2 |
Counted Citations from 1950-2000 | 1209 |
ION CHANNEL |
KCNJ11 | Gene Symbol |
Target Class | Transporters |
Target Subclass | TC:1.A.2.1 |
PA217 | PharmGKB ID |
ENSG00000187486 | Gene Symbol |
KCNJ11 | Ensembl Id |
DRUGGABLE GENOME |
KCNJ11 | GENE_SYMBOL |
ATP-sensitive inward rectifier potassium channel 11 | UNIPROT |
IKATP | UNIPROT |
ATP-sensitive inward rectifier potassium channel 11 | Gene Name |
Q14654 | UniProt ID |
ION CHANNEL |