DGIdb - KCNK3 Gene Record

KCNK3 3777 Druggable Genome

Alternate Names:

3777
POTASSIUM TWO PORE DOMAIN CHANNEL SUBFAMILY K MEMBER 3
KCNK3
K2p3.1
OAT1
PPH4
TASK
TASK-1
TBAK1
603220
6278
ENSG00000171303
OTTHUMG00000125530
O14649
TASK1
POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-1) (TWIK-RELATED ACID-SENSITIVE K(+) CHANNEL 1) (TWO PORE POTASSIUM CHANNEL KT3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:O14649]
Two pore K(+) channel KT3.1
Two pore potassium channel KT3.1
TWIK-related acid-sensitive K(+) channel 1
Acid-sensitive potassium channel protein TASK-1
Potassium channel subfamily K member 3
PA30060
TWIK-related acid-sensitive potassium channel 1
T15795

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	K2p3.1
Counted Citations from 1950-2000	204
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Pandit et al., 2010, Halothane and sevoflurane exert different degrees of inhibition on carotid body glomus cell intracellular Ca2+ response to hypoxia., Adv. Exp. Med. Biol.
Lazarenko et al., 2010, Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics., J. Neurosci.
Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension

DOXAPRAM HYDROCHLORIDE KCNK3

Interaction Score: 4.42

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CANDESARTAN KCNK3

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
HALOTHANE KCNK3

Interaction Score: 0.95

Interaction Types & Directionality:

activator (activating)

binder

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
20217349 20519544

Sources:
ChemblInteractions
ISOFLURANE KCNK3

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DESFLURANE KCNK3

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ENFLURANE KCNK3

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SEVOFLURANE KCNK3

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000171303
- Version: 101_38
Alternate Names:

KCNK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: KCNK3
- Version: February-2014
Alternate Names:

3777 Entrez Gene ID

Gene Info:

Initial Gene Query K2p3.1

Counted Citations from 1950-2000 204

Gene Categories:

ION CHANNEL

Publications:

RussLampel: ENSG00000171303

Version: 26-July-2011

Alternate Names:

ENSG00000171303 Ensembl Gene Id

POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-1) (TWIK-RELATED ACID-SENSITIVE K(+) CHANNEL 1) (TWO PORE POTASSIUM CHANNEL KT3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:O14649] Description

KCNK3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: KCNK3
- Version: 18-August-2020
Alternate Names:

PA30060 PharmGKB ID

Gene Info:

Publications:

Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
HingoraniCasas: ENSG00000171303
- Version: 31-May-2017
Alternate Names:

ENSG00000171303 Gene Symbol

KCNK3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TASK
- Version: chembl_23
Alternate Names:

TASK1 GENE_SYMBOL

KCNK3 GENE_SYMBOL

Potassium channel subfamily K member 3 UNIPROT

Gene Info:

Publications:
GO: KCNK3
- Version: 01-February-2022
Alternate Names:

TASK GO Gene Synonym

TASK1 GO Gene Synonym

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
TTD: TWIK-related acid-sensitive potassium channel 1
- Version: 2020.06.01
Alternate Names:

TASK1 TTD Gene Abbreviation

T15795 TTD Target ID

Gene Info:

Publications:
Pharos: KCNK3
- Version: 01-February-2022
Alternate Names:

Potassium channel subfamily K member 3 Gene Name

O14649 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	Potassium channel subfamily K member 3 blocker
Direct Interaction	yes

Mechanism of Interaction	Potassium channel subfamily K member 3 opener
Direct Interaction	yes

ENSG00000171303	Ensembl Gene Id
POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-1) (TWIK-RELATED ACID-SENSITIVE K(+) CHANNEL 1) (TWO PORE POTASSIUM CHANNEL KT3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:O14649]	Description
KCNK3	Display Id

TASK1	GENE_SYMBOL
KCNK3	GENE_SYMBOL
Potassium channel subfamily K member 3	UNIPROT

Potassium channel subfamily K member 3	Gene Name
O14649	UniProt ID

activator (activating)
binder

KCNK3 Gene Record

KCNK3 3777 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DOXAPRAM HYDROCHLORIDE KCNK3

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 3 blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

CANDESARTAN KCNK3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

HALOTHANE KCNK3

Interaction Types & Directionality: activator (activating) binder

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 3 opener Direct Interaction yes

PMIDs: 20217349 20519544

Sources: ChemblInteractions

ISOFLURANE KCNK3

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 3 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DESFLURANE KCNK3

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 3 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ENFLURANE KCNK3

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 3 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

SEVOFLURANE KCNK3

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 3 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000171303

Alternate Names: KCNK3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

BaderLabGenes: KCNK3

Alternate Names: 3777 Entrez Gene ID

Gene Info: Initial Gene Query K2p3.1 Counted Citations from 1950-2000 204

Gene Categories: ION CHANNEL

Publications:

RussLampel: ENSG00000171303

Alternate Names: ENSG00000171303 Ensembl Gene Id POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-1) (TWIK-RELATED ACID-SENSITIVE K(+) CHANNEL 1) (TWO PORE POTASSIUM CHANNEL KT3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:O14649] Description KCNK3 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: KCNK3

Alternate Names: PA30060 PharmGKB ID

Gene Info:

Publications: Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension

HingoraniCasas: ENSG00000171303

Alternate Names: ENSG00000171303 Gene Symbol KCNK3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: TASK

Alternate Names: TASK1 GENE_SYMBOL KCNK3 GENE_SYMBOL Potassium channel subfamily K member 3 UNIPROT

Gene Info:

Publications:

GO: KCNK3

Alternate Names: TASK GO Gene Synonym TASK1 GO Gene Synonym

Gene Info:

Gene Categories: ION CHANNEL

Publications:

TTD: TWIK-related acid-sensitive potassium channel 1

Alternate Names: TASK1 TTD Gene Abbreviation T15795 TTD Target ID

Gene Info:

Publications:

Pharos: KCNK3

Alternate Names: Potassium channel subfamily K member 3 Gene Name O14649 UniProt ID

Gene Info:

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

activator (activating)

binder

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
20217349 20519544

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 3 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

KCNK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

3777 Entrez Gene ID

Gene Info:

Initial Gene Query K2p3.1

Counted Citations from 1950-2000 204

Gene Categories:

ION CHANNEL

Alternate Names:

ENSG00000171303 Ensembl Gene Id

POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 (ACID-SENSITIVE POTASSIUM CHANNEL PROTEIN TASK-1) (TWIK-RELATED ACID-SENSITIVE K(+) CHANNEL 1) (TWO PORE POTASSIUM CHANNEL KT3.1). [SOURCE:UNIPROT/SWISSPROT;ACC:O14649] Description

KCNK3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA30060 PharmGKB ID

Publications:

Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension

Alternate Names:

ENSG00000171303 Gene Symbol

KCNK3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TASK1 GENE_SYMBOL

KCNK3 GENE_SYMBOL

Potassium channel subfamily K member 3 UNIPROT

Alternate Names:

TASK GO Gene Synonym

TASK1 GO Gene Synonym

Gene Categories:

ION CHANNEL

Alternate Names:

TASK1 TTD Gene Abbreviation

T15795 TTD Target ID

Alternate Names:

Potassium channel subfamily K member 3 Gene Name

O14649 UniProt ID

Gene Categories:

ION CHANNEL