DGIdb - KCNQ5 Gene Record

KCNQ5 56479 Druggable Genome

Alternate Names:

56479
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY Q MEMBER 5
KCNQ5
Kv7.5
MRD46
607357
6299
ENSG00000185760
OTTHUMG00000015020
Q9NR82
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5
KCNQ5_HUMAN
KQT-like 5
Voltage-gated potassium channel subunit Kv7.5
Potassium channel subunit alpha KvLQT5
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.5) (POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT5) (KQT-LIKE 5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NR82]
PA30077

Gene Info:

Interpro Acc	IPR005821
Interpro Type	Domain
Interpro Name	Ion transport domain
Human Readable Name	ION CHANNEL
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ion_trans_dom
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Initial Gene Query	Kv7.5
Counted Citations from 1950-2000	79
Target Class	Transporters
Target Subclass	TC:1.A.1.15
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Takahashi H et al., 2014, Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect., PLoS One
Borlak et al., 2006, N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II., Metab. Clin. Exp.
Hirano et al., 2007, Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice., Neurosci. Lett.
Hermann et al., 2003, Effects of age and sex on the disposition of retigabine., Clin. Pharmacol. Ther.
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

EZOGABINE KCNQ5

Interaction Score: 7.73

Interaction Types & Directionality:

activator (activating)

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

Direct Interaction yes

Trial Name retigabine, ezogabine,Potiga

PMIDs:
16713428 17184917 12545144

Sources:
TdgClinicalTrial ChemblInteractions
FLINDOKALNER KCNQ5

Interaction Score: 1.55

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel subunit Kv7.5 activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IRINOTECAN KCNQ5

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127363

Sources:
PharmGKB
CELECOXIB KCNQ5

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
TEDISAMIL KCNQ5

Interaction Score: 0.2

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GUANIDINE HYDROCHLORIDE KCNQ5

Interaction Score: 0.2

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DALFAMPRIDINE KCNQ5

Interaction Score: 0.18

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE KCNQ5

Interaction Score: 0.15

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000185760
- Version: 101_38
Alternate Names:

KCNQ5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q9NR82
- Version: 11-September-2012
Alternate Names:

56479 Entrez Gene Id

KCNQ5 Uniprot Gene Name

KCNQ5_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR005821

Interpro Type Domain

Interpro Name Ion transport domain

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
BaderLabGenes: KCNQ5
- Version: February-2014
Alternate Names:

56479 Entrez Gene ID

Gene Info:

Initial Gene Query Kv7.5

Counted Citations from 1950-2000 79

Gene Categories:

ION CHANNEL

Publications:
TdgClinicalTrial: Q9NR82
- Version: January-2014
Alternate Names:

KCNQ5 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.15

Publications:

RussLampel: ENSG00000185760

Version: 26-July-2011

Alternate Names:

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.5) (POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT5) (KQT-LIKE 5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NR82] Description

KCNQ5 Display Id

ENSG00000185760 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: KCNQ5

Version: 18-August-2020

Alternate Names:

PA30077 PharmGKB ID

Gene Info:

Publications:

Takahashi H et al., 2014, Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect., PLoS One

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

HingoraniCasas: ENSG00000185760
- Version: 31-May-2017
Alternate Names:

ENSG00000185760 Gene Symbol

KCNQ5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KCNQ5
- Version: chembl_23
Alternate Names:

KCNQ5 GENE_SYMBOL

Potassium voltage-gated channel subfamily KQT member 5 UNIPROT

KQT-like 5 UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: KCNQ5
- Version: 19.3
Alternate Names:

ENSG00000185760 Ensembl Gene ID

Kv7.5 Human Protein Atlas Gene Synonym

Potassium voltage-gated channel subfamily Q member 5 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
Pharos: KCNQ5
- Version: 01-February-2022
Alternate Names:

Potassium voltage-gated channel subfamily KQT member 5 Gene Name

Q9NR82 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	KCNQ (Kv7) potassium channel blocker
Direct Interaction	yes
Trial Name	retigabine, ezogabine,Potiga

Mechanism of Interaction	Voltage-gated potassium channel blocker
Direct Interaction	yes

56479	Entrez Gene Id
KCNQ5	Uniprot Gene Name
KCNQ5_HUMAN	Uniprot Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.5) (POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT5) (KQT-LIKE 5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NR82]	Description
KCNQ5	Display Id
ENSG00000185760	Ensembl Gene Id

KCNQ5	GENE_SYMBOL
Potassium voltage-gated channel subfamily KQT member 5	UNIPROT
KQT-like 5	UNIPROT

Potassium voltage-gated channel subfamily KQT member 5	Gene Name
Q9NR82	UniProt ID

activator (activating)
blocker (inhibitory)

KCNQ5 Gene Record

KCNQ5 56479 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: activator (activating) blocker (inhibitory)

Interaction Info: Mechanism of Interaction KCNQ (Kv7) potassium channel blocker Direct Interaction yes Trial Name retigabine, ezogabine,Potiga

PMIDs: 16713428 17184917 12545144

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel subunit Kv7.5 activator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127363

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000185760

Alternate Names: KCNQ5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q9NR82

Alternate Names: 56479 Entrez Gene Id KCNQ5 Uniprot Gene Name KCNQ5_HUMAN Uniprot Id

Gene Info: Interpro Acc IPR005821 Interpro Type Domain Interpro Name Ion transport domain

Gene Categories: ION CHANNEL, DRUGGABLE GENOME

Publications:

BaderLabGenes: KCNQ5

Alternate Names: 56479 Entrez Gene ID

Gene Info: Initial Gene Query Kv7.5 Counted Citations from 1950-2000 79

Gene Categories: ION CHANNEL

Publications:

TdgClinicalTrial: Q9NR82

Alternate Names: KCNQ5 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.1.15

Publications:

RussLampel: ENSG00000185760

Alternate Names: POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.5) (POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT5) (KQT-LIKE 5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NR82] Description KCNQ5 Display Id ENSG00000185760 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: KCNQ5

Alternate Names: PA30077 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000185760

Alternate Names: ENSG00000185760 Gene Symbol KCNQ5 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: KCNQ5

Alternate Names: KCNQ5 GENE_SYMBOL Potassium voltage-gated channel subfamily KQT member 5 UNIPROT KQT-like 5 UNIPROT

Gene Info:

Publications:

HumanProteinAtlas: KCNQ5

Alternate Names: ENSG00000185760 Ensembl Gene ID Kv7.5 Human Protein Atlas Gene Synonym Potassium voltage-gated channel subfamily Q member 5 Human Protein Atlas Gene Description

Gene Info:

Gene Categories: ION CHANNEL

Publications:

Pharos: KCNQ5

Alternate Names: Potassium voltage-gated channel subfamily KQT member 5 Gene Name Q9NR82 UniProt ID

Interaction Types & Directionality:

activator (activating)

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

Direct Interaction yes

Trial Name retigabine, ezogabine,Potiga

PMIDs:
16713428 17184917 12545144

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel subunit Kv7.5 activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
25127363

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

KCNQ5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

56479 Entrez Gene Id

KCNQ5 Uniprot Gene Name

KCNQ5_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR005821

Interpro Type Domain

Interpro Name Ion transport domain

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

56479 Entrez Gene ID

Gene Info:

Initial Gene Query Kv7.5

Counted Citations from 1950-2000 79

Gene Categories:

ION CHANNEL

Alternate Names:

KCNQ5 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.15

Alternate Names:

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.5) (POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT5) (KQT-LIKE 5). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NR82] Description

KCNQ5 Display Id

ENSG00000185760 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA30077 PharmGKB ID

Alternate Names:

ENSG00000185760 Gene Symbol

KCNQ5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KCNQ5 GENE_SYMBOL

Potassium voltage-gated channel subfamily KQT member 5 UNIPROT

KQT-like 5 UNIPROT

Alternate Names:

ENSG00000185760 Ensembl Gene ID

Kv7.5 Human Protein Atlas Gene Synonym

Potassium voltage-gated channel subfamily Q member 5 Human Protein Atlas Gene Description

Gene Categories:

ION CHANNEL

Alternate Names:

Potassium voltage-gated channel subfamily KQT member 5 Gene Name

Q9NR82 UniProt ID

Gene Categories:

ION CHANNEL