DGIdb - LRRK2 Gene Record

LRRK2 120892 Druggable GenomeClinically Actionable

Alternate Names:

120892
LEUCINE RICH REPEAT KINASE 2
LRRK2
AURA17
DARDARIN
PARK8
RIPK7
ROCO2
609007
18618
ENSG00000188906
OTTHUMG00000059742
leucine-rich repeat kinase 2
Q5S007
T08123
DKFZp434H2111
FLJ45829
Leucine-rich repeat serine/threonine-protein kinase 2

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Zhang J et al., 2012, Characterization of TAE684 as a potent LRRK2 kinase inhibitor., Bioorg Med Chem Lett
Reith AD et al., 2012, GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor., Bioorg Med Chem Lett

CHEMBL2204495 LRRK2

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22863203

Sources:
DTC
ADAVOSERTIB LRRK2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PICTILISIB LRRK2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FASUDIL LRRK2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AST-487 LRRK2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALISERTIB LRRK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1997335 LRRK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL379975 LRRK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTOLISIB LRRK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PALBOCICLIB LRRK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 LRRK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 LRRK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22335897

Sources:
DTC
PD-0166285 LRRK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VANDETANIB LRRK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN LRRK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB LRRK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 LRRK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB LRRK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 LRRK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 LRRK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB LRRK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB LRRK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 LRRK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB LRRK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000188906
- Version: 101_38
Alternate Names:

LRRK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000188906
- Version: 26-July-2011
Alternate Names:

LRRK2 Display Id

ENSG00000188906 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: LRRK2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Reith AD et al., 2012, GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor., Bioorg Med Chem Lett

Zhang J et al., 2012, Characterization of TAE684 as a potent LRRK2 kinase inhibitor., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000188906
- Version: 31-May-2017
Alternate Names:

ENSG00000188906 Gene Symbol

LRRK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: LRRK2
- Version: 19.3
Alternate Names:

ENSG00000188906 Ensembl Gene ID

DKFZp434H2111 Human Protein Atlas Gene Synonym

FLJ45829 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: LRRK2
- Version: 01-February-2022
Alternate Names:

PARK8 GO Gene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
dGene: LRRK2
- Version: 27-Jun-2013
Alternate Names:

120892 Gene ID

AURA17 dGene Synonym

DARDARIN dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Leucine-rich repeat kinase 2
- Version: 2020.06.01
Alternate Names:

LRRK2 TTD Gene Abbreviation

T08123 TTD Target ID

Gene Info:

Publications:
Pharos: LRRK2
- Version: 01-February-2022
Alternate Names:

Leucine-rich repeat serine/threonine-protein kinase 2 Gene Name

Q5S007 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
FoundationOneGenes: LRRK2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

ENSG00000188906	Ensembl Gene ID
DKFZp434H2111	Human Protein Atlas Gene Synonym
FLJ45829	Human Protein Atlas Gene Synonym

Leucine-rich repeat serine/threonine-protein kinase 2	Gene Name
Q5S007	UniProt ID

LRRK2 Gene Record

LRRK2 120892 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22863203

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22335897

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22863203

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22335897

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

LRRK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

LRRK2 Display Id

ENSG00000188906 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

Reith AD et al., 2012, GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor., Bioorg Med Chem Lett

Zhang J et al., 2012, Characterization of TAE684 as a potent LRRK2 kinase inhibitor., Bioorg Med Chem Lett

Alternate Names:

ENSG00000188906 Gene Symbol

LRRK2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME