DGIdb - MAPK9 Gene Record

MAPK9 5601 Druggable Genome

Alternate Names:

5601
MITOGEN-ACTIVATED PROTEIN KINASE 9
MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
602896
6886
ENSG00000050748
OTTHUMG00000130934
MITOGEN-ACTIVATED PROTEIN KINASE 9 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK2) (C-JUN N-TERMINAL KINASE 2) (JNK-55). [SOURCE:UNIPROT/SWISSPROT;ACC:P45984]
P45984
MAPK 9
MAP kinase 9
c-Jun N-terminal kinase 2
Stress-activated protein kinase JNK2
Stress-activated protein kinase 1a
MK09_HUMAN
PA30630
T69375

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Costa-Pereira et al., 2000, Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis., Br. J. Cancer
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Kim YJ et al., 2015, Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells., Bioorg Med Chem Lett
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

CARDAMOMIN MAPK9

Interaction Score: 1.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25959811

Sources:
DTC
CC-401 MAPK9

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction c-Jun N-terminal kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRIMAPITIDE, C-TERMINAL ACID MAPK9

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AM-111

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TANZISERTIB MAPK9

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction c-Jun N-terminal kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENTAMAPIMOD MAPK9

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL210618 MAPK9

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-1487 MAPK9

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-202190 MAPK9

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
CAMPTOTHECIN MAPK9

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10839298

Sources:
NCI
DORAMAPIMOD MAPK9

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAK-715 MAPK9

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-203580 MAPK9

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL406845 MAPK9

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-220025 MAPK9

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB MAPK9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB
PAZOPANIB MAPK9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1997335 MAPK9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 MAPK9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OSI-632 MAPK9

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PALBOCICLIB MAPK9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 MAPK9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X MAPK9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB MAPK9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB MAPK9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB MAPK9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000050748
- Version: 101_38
Alternate Names:

MAPK9 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000050748

Version: 26-July-2011

Alternate Names:

ENSG00000050748 Ensembl Gene Id

MITOGEN-ACTIVATED PROTEIN KINASE 9 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK2) (C-JUN N-TERMINAL KINASE 2) (JNK-55). [SOURCE:UNIPROT/SWISSPROT;ACC:P45984] Description

MAPK9 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P45984
- Version: January-2014
Alternate Names:

MAPK9 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:
HopkinsGroom: P45984
- Version: 11-September-2012
Alternate Names:

MAPK9 Uniprot Gene Name

MK09_HUMAN Uniprot Id

ENSG00000050748 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Interpro Acc IPR002290

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
PharmGKB: MAPK9
- Version: 18-August-2020
Alternate Names:

PA30630 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

NCI: MAPK9

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Costa-Pereira et al., 2000, Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis., Br. J. Cancer

Eminel et al., 2004, JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine., J. Biol. Chem.

DTC: MAPK9

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kim YJ et al., 2015, Cardamonin induces autophagy and an antiproliferative effect through JNK activation in human colorectal carcinoma HCT116 cells., Bioorg Med Chem Lett

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000050748
- Version: 31-May-2017
Alternate Names:

ENSG00000050748 Gene Symbol

MAPK9 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: JNK2
- Version: chembl_23
Alternate Names:

PRKM9 GENE_SYMBOL

SAPK1A GENE_SYMBOL

MAPK9 GENE_SYMBOL

Gene Info:

Publications:
GO: MAPK9
- Version: 01-February-2022
Alternate Names:

JNK2 GO Gene Synonym

PRKM9 GO Gene Synonym

SAPK1A GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: MAPK9
- Version: 27-Jun-2013
Alternate Names:

5601 Gene ID

JNK-55 dGene Synonym

JNK2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Stress-activated protein kinase JNK2
- Version: 2020.06.01
Alternate Names:

JNK2 TTD Gene Abbreviation

T69375 TTD Target ID

Gene Info:

Publications:
Pharos: MAPK9
- Version: 01-February-2022
Alternate Names:

Mitogen-activated protein kinase 9 Gene Name

P45984 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:

Mechanism of Interaction	c-Jun N-terminal kinase 2 inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	c-Jun N-terminal kinase, JNK inhibitor

ENSG00000050748	Ensembl Gene Id
MITOGEN-ACTIVATED PROTEIN KINASE 9 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK2) (C-JUN N-TERMINAL KINASE 2) (JNK-55). [SOURCE:UNIPROT/SWISSPROT;ACC:P45984]	Description
MAPK9	Display Id

MAPK9	Uniprot Gene Name
MK09_HUMAN	Uniprot Id
ENSG00000050748	Ensembl Gene Id

JNK2	GO Gene Synonym
PRKM9	GO Gene Synonym
SAPK1A	GO Gene Synonym

Trial Name	AM-111
Novel drug target	Novel Target

MAPK9 Gene Record

MAPK9 5601 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25959811

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction c-Jun N-terminal kinase 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name AM-111 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction c-Jun N-terminal kinase 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22951114

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10839298

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20124951

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
25959811

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction c-Jun N-terminal kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AM-111

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction c-Jun N-terminal kinase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22951114

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10839298

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20124951

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a