DGIdb - MPL Gene Record

MPL 4352 Druggable GenomeClinically Actionable

Alternate Names:

4352
MPL PROTO-ONCOGENE, THROMBOPOIETIN RECEPTOR
MPL
C-MPL
CD110
MPLV
THCYT2
TPOR
159530
7217
ENSG00000117400
OTTHUMG00000007429
Thrombopoietin receptor
Proto-oncogene c-Mpl
Myeloproliferative leukemia protein
TPO-R
CD_antigen=CD110
P40238
TPOR_HUMAN
T16156
THPOR

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Target Subclass	Type1
Target Subclass	IG
Target Subclass	CytokineR
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Krzyzanski et al., 2013, Pharmacokinetic and pharmacodynamic modeling of romiplostim in animals., Pharm. Res.
Choong et al., 2013, Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors., J. Cell. Mol. Med.
Li X et al., 2012, Defective regulatory B-cell compartment in patients with immune thrombocytopenia., Blood
Kim ES, 2016, Lusutrombopag: First Global Approval., Drugs
Yoshida H et al., 2018, Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl., Exp Hematol
Khan et al., 2013, AKT is a therapeutic target in myeloproliferative neoplasms., Leukemia
Kuter, 2009, Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia., Annu. Rev. Med.
Guglielmelli et al., 2011, Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis., Blood

PROMACTA MPL

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ELTROMBOPAG OLAMINE MPL

Interaction Score: 5.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thrombopoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LUSUTROMBOPAG MPL

Interaction Score: 3.75

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
22859611 26666417 29274361

Sources:
TTD
ROMIPLOSTIM MPL

Interaction Score: 3.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thrombopoietin receptor agonist

Direct Interaction yes

Trial Name romiplostim, AMG 531,Nplate

PMIDs:
23250851

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ELTROMBOPAG MPL

Interaction Score: 3.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Promacta

Novel drug target Established target

PMIDs:
19642221

Sources:
TdgClinicalTrial TEND TTD
AVATROMBOPAG MPL

Interaction Score: 1.61

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Thrombopoietin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
RUXOLITINIB MPL

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ruxolitinib + TGX-221

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

PMIDs:
24251790

Sources:
JAX-CKB
MK-2206 MPL

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type myelofibrosis

Response Type sensitive

Approval Status Preclinical

PMIDs:
23748344

Sources:
JAX-CKB
PICTILISIB MPL

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type sensitive

combination therapy GDC-0941 + Ruxolitinib

Indication/Tumor Type Advanced Solid Tumor

PMIDs:
24251790

Sources:
JAX-CKB
EVEROLIMUS MPL

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type myelofibrosis

Response Type sensitive

Approval Status Phase II

PMIDs:
21725052

Sources:
JAX-CKB
DACTOLISIB MPL

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BEZ235 + Ruxolitinib

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

PMIDs:
24251790

Sources:
JAX-CKB

Ensembl: ENSG00000117400
- Version: 101_38
Alternate Names:

MPL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P40238
- Version: 01-August-2011
Alternate Names:

MPL Gene Symbol

TPOR_HUMAN Uniprot Id

ENSG00000117400 Ensembl Gene Id

Gene Info:

Target Subclass Type1

Target Subclass IG

Target Subclass CytokineR

Publications:
TdgClinicalTrial: P40238
- Version: January-2014
Alternate Names:

MPL Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:

JAX-CKB: MPL

Version: 27-September-2017

Alternate Names:

4352 CKB Entrez Id

MPL CKB Gene Synonym

C-MPL CKB Gene Synonym

Gene Info:

Publications:

Choong et al., 2013, Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors., J. Cell. Mol. Med.

Meyer et al., 2015, CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms., Cancer Cell

Guglielmelli et al., 2011, Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis., Blood

TTD: Thrombopoietin receptor
- Version: 2020.06.01
Alternate Names:

MPL TTD Gene Abbreviation

T16156 TTD Target ID

Gene Info:

Publications:

Li X et al., 2012, Defective regulatory B-cell compartment in patients with immune thrombocytopenia., Blood
HingoraniCasas: ENSG00000117400
- Version: 31-May-2017
Alternate Names:

ENSG00000117400 Gene Symbol

MPL Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TPOR
- Version: chembl_23
Alternate Names:

TPOR GENE_SYMBOL

MPL GENE_SYMBOL

Thrombopoietin receptor UNIPROT

Gene Info:

Publications:
GO: MPL
- Version: 01-February-2022
Alternate Names:

TPOR GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Tempus: MPL
- Version: 11-November-2018
Alternate Names:

MPL Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: MPL
- Version: 01-February-2022
Alternate Names:

Thrombopoietin receptor Gene Name

P40238 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: MPL
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: MPL
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: MPL
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Thrombopoietin receptor agonist
Direct Interaction	yes

combination therapy	Ruxolitinib + TGX-221
Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive

Indication/Tumor Type	myelofibrosis
Response Type	sensitive
Approval Status	Preclinical

combination therapy	BEZ235 + Ruxolitinib
Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive

MPL	Gene Symbol
TPOR_HUMAN	Uniprot Id
ENSG00000117400	Ensembl Gene Id

Trial Name	Promacta
Novel drug target	Established target

MPL Gene Record

MPL 4352 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Thrombopoietin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 22859611 26666417 29274361

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Thrombopoietin receptor agonist Direct Interaction yes Trial Name romiplostim, AMG 531,Nplate

PMIDs: 23250851

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Promacta Novel drug target Established target

PMIDs: 19642221

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Thrombopoietin receptor agonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Ruxolitinib + TGX-221 Indication/Tumor Type Advanced Solid Tumor Response Type sensitive

PMIDs: 24251790

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type myelofibrosis Response Type sensitive Approval Status Preclinical

PMIDs: 23748344

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Response Type sensitive combination therapy GDC-0941 + Ruxolitinib Indication/Tumor Type Advanced Solid Tumor

PMIDs: 24251790

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type myelofibrosis Response Type sensitive Approval Status Phase II

PMIDs: 21725052

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy BEZ235 + Ruxolitinib Indication/Tumor Type Advanced Solid Tumor Response Type sensitive

PMIDs: 24251790

Sources: JAX-CKB

Ensembl: ENSG00000117400

Alternate Names: MPL Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P40238

Alternate Names: MPL Gene Symbol TPOR_HUMAN Uniprot Id ENSG00000117400 Ensembl Gene Id

Gene Info: Target Subclass Type1 Target Subclass IG Target Subclass CytokineR

Publications:

TdgClinicalTrial: P40238

Alternate Names: MPL Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

JAX-CKB: MPL

Alternate Names: 4352 CKB Entrez Id MPL CKB Gene Synonym C-MPL CKB Gene Synonym

Gene Info:

TTD: Thrombopoietin receptor

Alternate Names: MPL TTD Gene Abbreviation T16156 TTD Target ID

Gene Info:

Publications: Li X et al., 2012, Defective regulatory B-cell compartment in patients with immune thrombocytopenia., Blood

HingoraniCasas: ENSG00000117400

Alternate Names: ENSG00000117400 Gene Symbol MPL Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: TPOR

Alternate Names: TPOR GENE_SYMBOL MPL GENE_SYMBOL Thrombopoietin receptor UNIPROT

Gene Info:

Publications:

GO: MPL

Alternate Names: TPOR GO Gene Synonym

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thrombopoietin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

PMIDs:
22859611 26666417 29274361

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thrombopoietin receptor agonist

Direct Interaction yes

Trial Name romiplostim, AMG 531,Nplate

PMIDs:
23250851

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Promacta

Novel drug target Established target

PMIDs:
19642221

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Thrombopoietin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Ruxolitinib + TGX-221

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

PMIDs:
24251790

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type myelofibrosis

Response Type sensitive

Approval Status Preclinical

PMIDs:
23748344

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type sensitive

combination therapy GDC-0941 + Ruxolitinib

Indication/Tumor Type Advanced Solid Tumor

PMIDs:
24251790

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type myelofibrosis

Response Type sensitive

Approval Status Phase II

PMIDs:
21725052

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BEZ235 + Ruxolitinib

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

PMIDs:
24251790

Sources:
JAX-CKB

Alternate Names:

MPL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

MPL Gene Symbol

TPOR_HUMAN Uniprot Id

ENSG00000117400 Ensembl Gene Id

Gene Info:

Target Subclass Type1

Target Subclass IG

Target Subclass CytokineR

Alternate Names:

MPL Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

4352 CKB Entrez Id

MPL CKB Gene Synonym

C-MPL CKB Gene Synonym

Alternate Names:

MPL TTD Gene Abbreviation

T16156 TTD Target ID

Publications:

Li X et al., 2012, Defective regulatory B-cell compartment in patients with immune thrombocytopenia., Blood

Alternate Names:

ENSG00000117400 Gene Symbol

MPL Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPOR GENE_SYMBOL

MPL GENE_SYMBOL

Thrombopoietin receptor UNIPROT

Alternate Names:

TPOR GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

MPL Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Thrombopoietin receptor Gene Name

P40238 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE