DGIdb - NGF Gene Record

NGF 4803 Druggable Genome

Alternate Names:

4803
NERVE GROWTH FACTOR
NGF
Beta-NGF
HSAN5
NGFB
162030
7808
ENSG00000134259
OTTHUMG00000011880
Beta-nerve growth factor
P01138
PA162397475
T85670

Gene Info:

Target Class	Miscellaneous
Target Subclass	Nerve Growth Factor
Target Subclass	Neurotrophins
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
GROWTH FACTOR
DRUGGABLE GENOME

Publications:

Levran O et al., 2013, Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction., Pharmacogenomics
Levran O et al., 2012, Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., Pharmacogenomics J

TANEZUMAB NGF

Interaction Score: 37.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name tanezumab, PF-4383119, RI 624

Novel drug target Novel Target

Mechanism of Interaction Beta-nerve growth factor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
FASINUMAB NGF

Interaction Score: 24.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-nerve growth factor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
MEDI-578 NGF

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FULRANUMAB NGF

Interaction Score: 6.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-nerve growth factor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHADONE NGF

Interaction Score: 1.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23651024 21358750

Sources:
PharmGKB

Ensembl: ENSG00000134259
- Version: 101_38
Alternate Names:

NGF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P01138
- Version: January-2014
Alternate Names:

NGF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Nerve Growth Factor

Target Subclass Neurotrophins

Publications:

PharmGKB: NGF

Version: 18-August-2020

Alternate Names:

PA162397475 PharmGKB ID

Gene Info:

Publications:

Levran O et al., 2012, Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., Pharmacogenomics J

Levran O et al., 2013, Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction., Pharmacogenomics

ChemblInteractions: NGFB
- Version: chembl_23
Alternate Names:

NGFB GENE_SYMBOL

NGF GENE_SYMBOL

Beta-nerve growth factor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000134259
- Version: 31-May-2017
Alternate Names:

ENSG00000134259 Gene Symbol

NGF Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: NGF
- Version: 01-February-2022
Alternate Names:

NGFB GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
TTD: Nerve growth factor
- Version: 2020.06.01
Alternate Names:

NGF TTD Gene Abbreviation

T85670 TTD Target ID

Gene Info:

Publications:
Pharos: NGF
- Version: 01-February-2022
Alternate Names:

Beta-nerve growth factor Gene Name

P01138 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Trial Name	tanezumab, PF-4383119, RI 624
Novel drug target	Novel Target
Mechanism of Interaction	Beta-nerve growth factor inhibitor

Mechanism of Interaction	Beta-nerve growth factor inhibitor
Direct Interaction	yes

NGFB	GENE_SYMBOL
NGF	GENE_SYMBOL
Beta-nerve growth factor	UNIPROT

NGF Gene Record

NGF 4803 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TANEZUMAB NGF

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name tanezumab, PF-4383119, RI 624 Novel drug target Novel Target Mechanism of Interaction Beta-nerve growth factor inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

FASINUMAB NGF

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Beta-nerve growth factor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

MEDI-578 NGF

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

FULRANUMAB NGF

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Beta-nerve growth factor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

METHADONE NGF

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23651024 21358750

Sources: PharmGKB

Ensembl: ENSG00000134259

Alternate Names: NGF Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P01138

Alternate Names: NGF Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Nerve Growth Factor Target Subclass Neurotrophins

Publications:

PharmGKB: NGF

Alternate Names: PA162397475 PharmGKB ID

Gene Info:

ChemblInteractions: NGFB

Alternate Names: NGFB GENE_SYMBOL NGF GENE_SYMBOL Beta-nerve growth factor UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000134259

Alternate Names: ENSG00000134259 Gene Symbol NGF Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: NGF

Alternate Names: NGFB GO Gene Synonym

Gene Info:

Gene Categories: GROWTH FACTOR

Publications:

TTD: Nerve growth factor

Alternate Names: NGF TTD Gene Abbreviation T85670 TTD Target ID

Gene Info:

Publications:

Pharos: NGF

Alternate Names: Beta-nerve growth factor Gene Name P01138 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name tanezumab, PF-4383119, RI 624

Novel drug target Novel Target

Mechanism of Interaction Beta-nerve growth factor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-nerve growth factor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Beta-nerve growth factor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23651024 21358750

Sources:
PharmGKB

Alternate Names:

NGF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

NGF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Nerve Growth Factor

Target Subclass Neurotrophins

Alternate Names:

PA162397475 PharmGKB ID

Alternate Names:

NGFB GENE_SYMBOL

NGF GENE_SYMBOL

Beta-nerve growth factor UNIPROT

Alternate Names:

ENSG00000134259 Gene Symbol

NGF Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NGFB GO Gene Synonym

Gene Categories:

GROWTH FACTOR

Alternate Names:

NGF TTD Gene Abbreviation

T85670 TTD Target ID

Alternate Names:

Beta-nerve growth factor Gene Name

P01138 UniProt ID

Gene Categories:

KINASE