DGIdb - NOD2 Gene Record

NOD2 64127 Druggable Genome

Alternate Names:

64127
NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN CONTAINING 2
NOD2
ACUG
BLAU
BLAUS
CARD15
CD
CLR16.3
IBD1
NLRC2
NOD2B
PSORAS1
YAOS
605956
5331
ENSG00000167207
OTTHUMG00000133171
Nucleotide-binding oligomerization domain-containing protein 2
Inflammatory bowel disease protein 1
Caspase recruitment domain-containing protein 15
Q9HC29
PA26074
Pattern recognition receptor NOD2
T75643

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
DRUGGABLE GENOME

Publications:

Ando K et al., 2011, Mifamurtide for the treatment of nonmetastatic osteosarcoma., Expert Opin Pharmacother
Kager L et al., 2010, Review of mifamurtide in the treatment of patients with osteosarcoma., Ther Clin Risk Manag
Jakopin Ž et al., 2012, Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides., J Med Chem
Bosó V et al., 2013, Increased hospital stay and allograft dysfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285., Drug Metab Dispos

MIFAMURTIDE NOD2

Interaction Score: 15.46

Interaction Types & Directionality:

ligand

Interaction Info:

Mechanism of Interaction Nucleotide-binding oligomerization domain-containing protein 2 other

Direct Interaction yes

PMIDs:
21226638 20596505

Sources:
ChemblInteractions
MURABUTIDE NOD2

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22716113

Sources:
DTC
INARIGIVIR SOPROXIL NOD2

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1351908 NOD2

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL599890 NOD2

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1456848 NOD2

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL577660 NOD2

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL590706 NOD2

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOVALONE NOD2

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578944 NOD2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL585502 NOD2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TACROLIMUS NOD2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23175667

Sources:
PharmGKB

Ensembl: ENSG00000167207
- Version: 101_38
Alternate Names:

NOD2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: NOD2
- Version: 18-August-2020
Alternate Names:

PA26074 PharmGKB ID

Gene Info:

Publications:

Bosó V et al., 2013, Increased hospital stay and allograft dysfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285., Drug Metab Dispos
DTC: NOD2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Jakopin Ž et al., 2012, Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides., J Med Chem
HingoraniCasas: ENSG00000167207
- Version: 31-May-2017
Alternate Names:

ENSG00000167207 Gene Symbol

NOD2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CARD15
- Version: chembl_23
Alternate Names:

IBD1 GENE_SYMBOL

NOD2 GENE_SYMBOL

Nucleotide-binding oligomerization domain-containing protein 2 UNIPROT

Gene Info:

Publications:
GO: NOD2
- Version: 01-February-2022
Alternate Names:

CARD15 GO Gene Synonym

IBD1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Pattern recognition receptor NOD2
- Version: 2020.06.01
Alternate Names:

NOD2 TTD Gene Abbreviation

T75643 TTD Target ID

Gene Info:

Publications:
Pharos: NOD2
- Version: 01-February-2022
Alternate Names:

Nucleotide-binding oligomerization domain-containing protein 2 Gene Name

Q9HC29 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Mechanism of Interaction	Nucleotide-binding oligomerization domain-containing protein 2 other
Direct Interaction	yes

IBD1	GENE_SYMBOL
NOD2	GENE_SYMBOL
Nucleotide-binding oligomerization domain-containing protein 2	UNIPROT

Nucleotide-binding oligomerization domain-containing protein 2	Gene Name
Q9HC29	UniProt ID

NOD2 Gene Record

NOD2 64127 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: ligand

Interaction Info: Mechanism of Interaction Nucleotide-binding oligomerization domain-containing protein 2 other Direct Interaction yes

PMIDs: 21226638 20596505

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22716113

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23175667

Sources: PharmGKB

Ensembl: ENSG00000167207

Alternate Names: NOD2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: NOD2

Alternate Names: PA26074 PharmGKB ID

Gene Info:

Publications: Bosó V et al., 2013, Increased hospital stay and allograft dysfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285., Drug Metab Dispos

DTC: NOD2

Alternate Names:

Gene Info:

Publications: Jakopin Ž et al., 2012, Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides., J Med Chem

HingoraniCasas: ENSG00000167207

Alternate Names: ENSG00000167207 Gene Symbol NOD2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: CARD15

Alternate Names: IBD1 GENE_SYMBOL NOD2 GENE_SYMBOL Nucleotide-binding oligomerization domain-containing protein 2 UNIPROT

Gene Info:

Publications:

GO: NOD2

Alternate Names: CARD15 GO Gene Synonym IBD1 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

ligand

Interaction Info:

Mechanism of Interaction Nucleotide-binding oligomerization domain-containing protein 2 other

Direct Interaction yes

PMIDs:
21226638 20596505

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22716113

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23175667

Sources:
PharmGKB

Alternate Names:

NOD2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA26074 PharmGKB ID

Publications:

Bosó V et al., 2013, Increased hospital stay and allograft dysfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285., Drug Metab Dispos

Publications:

Jakopin Ž et al., 2012, Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides., J Med Chem

Alternate Names:

ENSG00000167207 Gene Symbol

NOD2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IBD1 GENE_SYMBOL

NOD2 GENE_SYMBOL

Nucleotide-binding oligomerization domain-containing protein 2 UNIPROT

Alternate Names:

CARD15 GO Gene Synonym

IBD1 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

NOD2 TTD Gene Abbreviation

T75643 TTD Target ID

Alternate Names:

Nucleotide-binding oligomerization domain-containing protein 2 Gene Name

Q9HC29 UniProt ID

Gene Categories:

KINASE