DGIdb - NR3C2 Gene Record

NR3C2 4306 Druggable Genome

Alternate Names:

4306
NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 2
NR3C2
MCR
MLR
MR
NR3C2VIT
600983
7979
ENSG00000151623
OTTHUMG00000161455
Mineralocorticoid receptor
P08235
MCR_HUMAN
MINERALOCORTICOID RECEPTOR (MR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08235]
PA242
T72168
Melanocortin receptor
T45457

Gene Info:

Target Class	Receptors
Target Subclass	Nuclear receptor
Interpro Acc	IPR000536
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Interpro Type	Domain
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Initial Gene Query	NR3C2
Counted Citations from 1950-2000	2269
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Rupprecht et al., 1993, Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands., Eur. J. Pharmacol.
Souque A et al., 1995, The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent., Endocrinology
Quinkler M et al., 2002, Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor., Eur J Endocrinol
Myles K et al., 1996, Progesterone binding to mineralocorticoid receptors: in vitro and in vivo studies., Am J Physiol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sekihara et al., 1978, New mineralocorticoids: 5alpha-dihydroaldosterone and 5alpha-dihydro-11-deoxycorticosterone., Endocrinology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Beaumont et al., 1983, Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone., Endocrinology
Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension
Young et al., 1996, Mineralocorticoids, salt, hypertension: effects on the heart., Steroids
Oelkers et al., 1994, Impaired renal 11 beta-oxidation of 9 alpha-fluorocortisol: an explanation for its mineralocorticoid potency., J. Clin. Endocrinol. Metab.
Otte et al., 2003, The mineralocorticoid receptor agonist, fludrocortisone, inhibits pituitary-adrenal activity in humans after pre-treatment with metyrapone., Life Sci.
Kingsley-Kallesen et al., 2002, The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development., Mol. Endocrinol.
Buckley et al., The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic-adrenal-pituitary (HPA) axis activity in healthy controls., Psychoneuroendocrinology
Agarwal MK et al., 1977, Physiological activity and receptor binding of 9 alpha fluorohydrocortisone., Biochem Biophys Res Commun
Lan NC et al., 1982, Binding of steroids to mineralocorticoid receptors: implications for in vivo occupancy by glucocorticoids., J Clin Endocrinol Metab
Krattenmacher, 2000, Drospirenone: pharmacology and pharmacokinetics of a unique progestogen., Contraception
Oelkers, 1996, Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure., Steroids
Muhn et al., 1995, Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity., Ann. N. Y. Acad. Sci.
Fuhrmann et al., 1996, The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential., Contraception
Oelkers W, 2002, Antimineralocorticoid activity of a novel oral contraceptive containing drospirenone, a unique progestogen resembling natural progesterone., Eur J Contracept Reprod Health Care
Oelkers W, 2004, Drospirenone, a progestogen with antimineralocorticoid properties: a short review., Mol Cell Endocrinol
Moore et al., Eplerenone: a selective aldosterone receptor antagonist for hypertension and heart failure., Heart Dis
Rogerson et al., 2004, Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor., Clin. Exp. Pharmacol. Physiol.
Fraccarollo et al., 2003, Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction., J. Am. Coll. Cardiol.
Sica, 2005, Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis., Heart Fail Rev
Rogerson et al., 2003, Determinants of spironolactone binding specificity in the mineralocorticoid receptor., J. Mol. Endocrinol.
Gertner et al., 2004, Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor., J. Am. Soc. Nephrol.
Frishman et al., 2004, Aldosterone and aldosterone antagonism in systemic hypertension., Curr. Hypertens. Rep.
Sitruk-Ware, Progestogens in hormonal replacement therapy: new molecules, risks, and benefits., Menopause
Rossi et al., 2005, Aldosterone as a cardiovascular risk factor., Trends Endocrinol. Metab.
Luo JQ et al., 2014, Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment., Pharmacogenomics
Bruner et al., 1997, The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52., Recept Signal Transduct
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Bunda et al., 2007, Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor-independent manner., Am. J. Pathol.
Lu et al., 2006, International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors., Pharmacol. Rev.

FLUDROCORTISONE NR3C2

Interaction Score: 18.89

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8733007 8157723 12888122 11752352 12198239 17666187 907708 6274900

Sources:
TdgClinicalTrial TEND TTD
EPLERENONE NR3C2

Interaction Score: 13.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name eplerenone tablets,Inspra

Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs:
14503934 15554912 14607457 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DESOXYCORTICOSTERONE PIVALATE NR3C2

Interaction Score: 10.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor agonist

Direct Interaction yes

PMIDs:
11752352 744157 17016423 17139284 6227474

Sources:
ChemblInteractions
DROSPIRENONE NR3C2

Interaction Score: 8.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ethinyl estradiol + drospirenone,Yaz

Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs:
11024226 11752352 8732994 7625729 8922878 12659403 15134826

Sources:
TdgClinicalTrial ChemblInteractions TTD
MT-3995 NR3C2

Interaction Score: 6.87

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
LY2623091 NR3C2

Interaction Score: 6.87

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
XL550 NR3C2

Interaction Score: 6.87

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
FINERENONE NR3C2

Interaction Score: 6.87

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
DESOXYCORTICOSTERONE ACETATE NR3C2

Interaction Score: 3.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor agonist

Direct Interaction yes

PMIDs:
17132855

Sources:
ChemblInteractions
PF-03882845 NR3C2

Interaction Score: 3.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUDROCORTISONE ACETATE NR3C2

Interaction Score: 3.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Mineralocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
ALDOSTERONE NR3C2

Interaction Score: 2.75

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
9392437 10592235 17724138

Sources:
TTD
SPIRONOLACTONE NR3C2

Interaction Score: 2.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

Trial Name HTI-101

PMIDs:
15947888 14664717 15554912 14978157 15128471 11791081 11752352 15808807

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BREMELANOTIDE NR3C2

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FELODIPINE NR3C2

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions
NIMODIPINE NR3C2

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions
ENALAPRIL NR3C2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24059494

Sources:
PharmGKB
PROGESTERONE NR3C2

Interaction Score: 0.26

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name BHR-100

Novel drug target Established target

Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

PMIDs:
8282004 7588320 12039699 8928765

Sources:
TdgClinicalTrial

Ensembl: ENSG00000151623
- Version: 101_38
Alternate Names:

NR3C2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000151623
- Version: 26-July-2011
Alternate Names:

MINERALOCORTICOID RECEPTOR (MR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08235] Description

NR3C2 Display Id

ENSG00000151623 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P08235
- Version: January-2014
Alternate Names:

NR3C2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
TEND: P08235
- Version: 01-August-2011
Alternate Names:

P08235 Uniprot Accession

4306 Entrez Gene Id

MCR_HUMAN Uniprot Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Publications:
BaderLabGenes: NR3C2
- Version: February-2014
Alternate Names:

4306 Entrez Gene ID

Gene Info:

Initial Gene Query NR3C2

Counted Citations from 1950-2000 2269

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P08235
- Version: 11-September-2012
Alternate Names:

MCR_HUMAN Uniprot Id

MINERALOCORTICOID RECEPTOR Uniprot Protein Name

ENSG00000151623 Ensembl Gene Id

Gene Info:

Interpro Acc IPR000536

Interpro Name Nuclear hormone receptor, ligand-binding, core

Interpro Type Domain

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
PharmGKB: NR3C2
- Version: 18-August-2020
Alternate Names:

PA242 PharmGKB ID

Gene Info:

Publications:

Luo JQ et al., 2014, Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment., Pharmacogenomics
HingoraniCasas: ENSG00000151623
- Version: 31-May-2017
Alternate Names:

ENSG00000151623 Gene Symbol

NR3C2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: MCR
- Version: chembl_23
Alternate Names:

MLR GENE_SYMBOL

NR3C2 GENE_SYMBOL

Mineralocorticoid receptor UNIPROT

Gene Info:

Publications:
GO: NR3C2
- Version: 01-February-2022
Alternate Names:

MCR GO Gene Synonym

MLR GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: NR3C2
- Version: 27-Jun-2013
Alternate Names:

4306 Gene ID

MCR dGene Synonym

MLR dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Mineralocorticoid receptor
- Version: 2020.06.01
Alternate Names:

MR TTD Gene Abbreviation

T72168 TTD Target ID

Gene Info:

Publications:
TTD: Melanocortin receptor
- Version: 2020.06.01
Alternate Names:

MCR TTD Gene Abbreviation

T45457 TTD Target ID

Gene Info:

Publications:
Pharos: NR3C2
- Version: 01-February-2022
Alternate Names:

Mineralocorticoid receptor Gene Name

P08235 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Novel drug target	Established target
Trial Name	eplerenone tablets,Inspra
Mechanism of Interaction	Mineralocorticoid receptor antagonist

Mechanism of Interaction	Mineralocorticoid receptor agonist
Direct Interaction	yes

Trial Name	BHR-100
Novel drug target	Established target
Trial Name	conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

MINERALOCORTICOID RECEPTOR (MR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08235]	Description
NR3C2	Display Id
ENSG00000151623	Ensembl Gene Id

P08235	Uniprot Accession
4306	Entrez Gene Id
MCR_HUMAN	Uniprot Id

MLR	GENE_SYMBOL
NR3C2	GENE_SYMBOL
Mineralocorticoid receptor	UNIPROT

agonist (activating)
antagonist (inhibitory)

NR3C2 Gene Record

NR3C2 4306 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8733007 8157723 12888122 11752352 12198239 17666187 907708 6274900

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name eplerenone tablets,Inspra Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs: 14503934 15554912 14607457 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor agonist Direct Interaction yes

PMIDs: 11752352 744157 17016423 17139284 6227474

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ethinyl estradiol + drospirenone,Yaz Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs: 11024226 11752352 8732994 7625729 8922878 12659403 15134826

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor agonist Direct Interaction yes

PMIDs: 17132855

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Mineralocorticoid receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 9392437 10592235 17724138

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes Trial Name HTI-101

PMIDs: 15947888 14664717 15554912 14978157 15128471 11791081 11752352 15808807

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: 18250364

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: 18250364

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24059494

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name BHR-100 Novel drug target Established target Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

PMIDs: 8282004 7588320 12039699 8928765

Sources: TdgClinicalTrial

Ensembl: ENSG00000151623

Alternate Names: NR3C2 Ensembl Gene Name

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8733007 8157723 12888122 11752352 12198239 17666187 907708 6274900

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name eplerenone tablets,Inspra

Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs:
14503934 15554912 14607457 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor agonist

Direct Interaction yes

PMIDs:
11752352 744157 17016423 17139284 6227474

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ethinyl estradiol + drospirenone,Yaz

Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs:
11024226 11752352 8732994 7625729 8922878 12659403 15134826

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor agonist

Direct Interaction yes

PMIDs:
17132855

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Mineralocorticoid receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

PMIDs:
9392437 10592235 17724138

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

Trial Name HTI-101

PMIDs:
15947888 14664717 15554912 14978157 15128471 11791081 11752352 15808807

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24059494

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name BHR-100

Novel drug target Established target

Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

PMIDs:
8282004 7588320 12039699 8928765

Sources:
TdgClinicalTrial

Alternate Names:

NR3C2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

MINERALOCORTICOID RECEPTOR (MR). [SOURCE:UNIPROT/SWISSPROT;ACC:P08235] Description

NR3C2 Display Id

ENSG00000151623 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NR3C2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Alternate Names:

P08235 Uniprot Accession

4306 Entrez Gene Id

MCR_HUMAN Uniprot Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Alternate Names:

4306 Entrez Gene ID

Gene Info:

Initial Gene Query NR3C2

Counted Citations from 1950-2000 2269