4915 |
NEUROTROPHIC RECEPTOR TYROSINE KINASE 2 |
NTRK2 |
GP145-TrkB |
OBHD |
TRKB |
trk-B |
600456 |
8032 |
ENSG00000148053 |
OTTHUMG00000020120 |
Q16620 |
NTRK2_HUMAN |
BDNF/NT-3 GROWTH FACTORS RECEPTOR |
Neurotrophic tyrosine kinase receptor type 2 |
TrkB tyrosine kinase |
Tropomyosin-related kinase B |
BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 2) (TRKB TYROSINE KINASE) (GP145-TRKB) (TRK-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16620] |
3984 |
PA31818 |
T84703 |
DEE58 |
EIEE58 |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
Interpro Acc | IPR001245 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Human Readable Name | KINASE |
Uniprot Status | Swiss-Prot |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Initial Gene Query | TRKB |
Counted Citations from 1950-2000 | 2113 |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
Gene Biotype | PROTEIN_CODING |
KINASE |
TYROSINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor type 2 inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor type 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor type 2 inhibitor |
Direct Interaction | yes |
Trial Name | lestaurtinib , CEP-701 |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Neurotrophic tyrosine kinase receptor inhibitor |
Direct Interaction | yes |
NTRK2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
NTRK2 | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
4915 | Entrez Gene ID |
Initial Gene Query | TRKB |
Counted Citations from 1950-2000 | 2113 |
KINASE |
NTRK2 | Display Id |
ENSG00000148053 | Ensembl Gene Id |
BDNF/NT-3 GROWTH FACTORS RECEPTOR PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 2) (TRKB TYROSINE KINASE) (GP145-TRKB) (TRK-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q16620] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000148053 | Ensembl Gene Id |
4915 | Entrez Gene Id |
NTRK2_HUMAN | Uniprot Id |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
KINASE, DRUGGABLE GENOME |
PA31818 | PharmGKB ID |
4915 | Entrez Gene ID |
3984 | CIViC Gene ID |
TRKB | GENE_SYMBOL |
NTRK2 | GENE_SYMBOL |
BDNF/NT-3 growth factors receptor | UNIPROT |
ENSG00000148053 | Gene Symbol |
NTRK2 | Ensembl Id |
DRUGGABLE GENOME |
4915 | OncoKB Entrez Id |
TRKB | OncoKB Gene Synonym |
GP145-TrkB | OncoKB Gene Synonym |
ENSG00000148053 | Ensembl Gene ID |
TRKB | Human Protein Atlas Gene Synonym |
Neurotrophic receptor tyrosine kinase 2 | Human Protein Atlas Gene Description |
ENZYME |
NTRK2 | Gene Symbol |
CLINICALLY ACTIONABLE |
4915 | Gene ID |
GP145-TrkB | dGene Synonym |
TRKB | dGene Synonym |
KINASE, TYROSINE KINASE |
TrkB | TTD Gene Abbreviation |
T84703 | TTD Target ID |
BDNF/NT-3 growth factors receptor | Gene Name |
Q16620 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |