4988 |
OPIOID RECEPTOR MU 1 |
OPRM1 |
LMOR |
M-OR-1 |
MOP |
MOR |
MOR1 |
OPRM |
600018 |
8156 |
ENSG00000112038 |
OTTHUMG00000015870 |
P35372 |
OPRM_HUMAN |
MU-TYPE OPIOID RECEPTOR |
Mu opiate receptor |
Mu opioid receptor |
hMOP |
MOR-1 |
MU-TYPE OPIOID RECEPTOR (MOR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35372] |
PA31945 |
Target Subclass | GPCR |
Target Main Class | Receptors |
Transmembrane Helix Count | 7 |
Target Subclass | Rhodopsin |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
KINASE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Direct Interaction | yes |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
partial agonist (activating) |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor partial agonist |
Trial Name | - |
agonist (activating) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Trial Name | ALO-01, morphine sulfate and naltrexone hydrochloride,Embeda, Kadian NT |
antagonist (inhibitory) |
Trial Name | TD-1211 |
Novel drug target | Established target |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | Methylnaltrexone |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
antagonist (inhibitory) |
Trial Name | nalbuphine hydrochloride, PW-4142 |
Novel drug target | Established target |
Trial Name | REN-213 |
antagonist (inhibitory) |
Trial Name | REN-213 |
Trial Name | buprenorphine + naloxone,Suboxone |
Novel drug target | Established target |
agonist (activating) |
Trial Name | ARX-01, sufentanil NanoTab |
Novel drug target | Established target |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | COL-003, sustained release oxycodone |
Novel drug target | Established target |
Trial Name | PTI-801,Oxytrex |
partial agonist (activating) |
agonist (activating) |
Trial Name | V1003 |
Trial Name | CAM2038 |
Trial Name | Butrans is a transdermal patch formulation of buprenorphine, a partial agonist at mu opioid receptors and an antagonist at kappa opioid receptors. It is indicated as an analgesic to deliver continuous pain relief for seven days. The efficacy of Butrans |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Novel drug target | Established target |
Trial Name | NKTR-181 |
partial agonist (activating) |
Mechanism of Interaction | Mu opioid receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor antagonist |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Mu opioid receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Trial Name | tramadol,Tridural, Ryzolt |
Trial Name | tramadol hydrochloride,Ultram |
Trial Name | tramadol extended-release,Raliva ER |
agonist (activating) |
Trial Name | tapentadol |
Novel drug target | Established target |
Trial Name | tapentadol hydrochloride, CG-5503, R331333 |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor agonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Mu opioid receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Mu opioid receptor antagonist |
agonist (activating) |
Trial Name | AD 923 |
Novel drug target | Established target |
Trial Name | AeroLEF |
agonist (activating) |
Trial Name | ALO-01, morphine sulfate and naltrexone hydrochloride,Embeda, Kadian NT |
Novel drug target | Established target |
Trial Name | intranasal morphine,Rylomine |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
n/a |
Trial Name | KP201 (prodrug of hydrocodone) |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | nalmefene, CPH-101 |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta antagonist |
agonist (activating) |
Mechanism of Interaction | Mu opioid receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Opioid receptors; mu/kappa/delta agonist |
Direct Interaction | yes |
OPRM1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
OPRM1 | Gene Symbol |
MOR | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
4988 | Entrez Gene Id |
MU-TYPE OPIOID RECEPTOR | Uniprot Protein Name |
ENSG00000112038 | Ensembl Gene Id |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
P35372 | Uniprot Accession |
OPRM1 | Gene Symbol |
4988 | Entrez Gene Id |
Target Subclass | GPCR |
Target Main Class | Receptors |
Transmembrane Helix Count | 7 |
OPRM1 | Display Id |
ENSG00000112038 | Ensembl Gene Id |
MU-TYPE OPIOID RECEPTOR (MOR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35372] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PA31945 | PharmGKB ID |
ENSG00000112038 | Gene Symbol |
OPRM1 | Ensembl Id |
DRUGGABLE GENOME |
MOR1 | GENE_SYMBOL |
OPRM1 | GENE_SYMBOL |
Mu-type opioid receptor | UNIPROT |
MOR1 | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
4988 | Gene ID |
LMOR | dGene Synonym |
M-OR-1 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
Mu-type opioid receptor | Gene Name |
P35372 | UniProt ID |
KINASE, G PROTEIN COUPLED RECEPTOR |