64805 |
PURINERGIC RECEPTOR P2Y12 |
P2RY12 |
ADPG-R |
BDPLT8 |
HORK3 |
P2T(AC) |
P2Y(12)R |
P2Y(AC) |
P2Y(ADP) |
P2Y(cyc) |
P2Y12 |
SP1999 |
600515 |
18124 |
ENSG00000169313 |
OTTHUMG00000159863 |
Q9H244 |
P2Y12 PLATELET ADP RECEPTOR |
ADP-GLUCOSE RECEPTOR |
P2Y PURINOCEPTOR 12 |
PA134971947 |
P2Y12_HUMAN |
P2Y PURINOCEPTOR 12 (P2Y12) (P2Y12 PLATELET ADP RECEPTOR) (P2Y(ADP)) (ADP-GLUCOSE RECEPTOR) (ADPG-R) (P2Y(AC)) (P2Y(CYC)) (P2T(AC)) (SP1999). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H244] |
T46937 |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Uniprot Status | Swiss-Prot |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | cangrelor, AR69931 |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | INS-50589 |
Novel drug target | Established target |
Mechanism of Interaction | Purinergic receptor P2Y12 antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Purinergic receptor P2Y12 antagonist |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Purinergic receptor P2Y12 antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Purinergic receptor P2Y12 antagonist |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Purinergic receptor P2Y12 negative allosteric modulator |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Purinergic receptor P2Y12 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Purinergic receptor P2Y12 antagonist |
P2RY12 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
P2Y12_HUMAN | Uniprot Id |
P2RY12 | Gene Symbol |
64805 | Entrez Gene Id |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Target Subclass | GPCR |
ENSG00000169313 | Ensembl Gene Id |
P2RY12 | Display Id |
P2Y PURINOCEPTOR 12 (P2Y12) (P2Y12 PLATELET ADP RECEPTOR) (P2Y(ADP)) (ADP-GLUCOSE RECEPTOR) (ADPG-R) (P2Y(AC)) (P2Y(CYC)) (P2T(AC)) (SP1999). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9H244] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
Q9H244 | Uniprot Accession |
ENSG00000169313 | Ensembl Gene Id |
P2Y12_HUMAN | Uniprot Id |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Uniprot Evidence | 1: Evidence at protein level |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
P2RY12 | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
PA134971947 | PharmGKB ID |
HORK3 | GENE_SYMBOL |
P2RY12 | GENE_SYMBOL |
P2Y purinoceptor 12 | UNIPROT |
ENSG00000169313 | Gene Symbol |
P2RY12 | Ensembl Id |
DRUGGABLE GENOME |
HORK3 | GO Gene Synonym |
CELL SURFACE |
64805 | Gene ID |
ADPG-R | dGene Synonym |
BDPLT8 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
P2RY12 | TTD Gene Abbreviation |
T46937 | TTD Target ID |