DGIdb - PARP2 Gene Record

PARP2 10038 Druggable GenomeClinically Actionable

Alternate Names:

10038
POLY(ADP-RIBOSE) POLYMERASE 2
PARP2
ADPRT2
ADPRTL2
ADPRTL3
ARTD2
PARP-2
pADPRT-2
607725
272
ENSG00000129484
OTTHUMG00000166106
Q9UGN5
POLY [ADP-RIBOSE] POLYMERASE 2
PARP2_HUMAN
NAD(+) ADP-ribosyltransferase 2
ADP-ribosyltransferase diphtheria toxin-like 2
hPARP-2
Poly[ADP-ribose] synthase 2
ADPRT-2
PARP
POLY [ADP-RIBOSE] POLYMERASE-2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- RIBOSYLTRANSFERASE-2) (POLY[ADP-RIBOSE] SYNTHETASE-2) (PADPRT-2) (HPARP-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UGN5]
PA24592
T40812

Gene Info:

Interpro Name	Poly(ADP-ribose) polymerase, catalytic domain
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR012317
Interpro Short Name	Poly(ADP-ribose)pol_cat_dom
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Target Class	Enzymes
Target Subclass	EC:2.4.2.30
CancerCommons Reported Gene Name	PARP
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

DNA REPAIR
HISTONE MODIFICATION
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Verhagen et al., 2015, Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells., Radiother Oncol
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wang B et al., 2016, Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent., J Med Chem

VELIPARIB PARP2

Interaction Score: 6.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PARP 1, 2 and 3 inhibitor

Direct Interaction yes

Notes

PMIDs:
10592235

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial
NIRAPARIB PARP2

Interaction Score: 4.91

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions
TALAZOPARIB TOSYLATE PARP2

Interaction Score: 4.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
RUCAPARIB CAMSYLATE PARP2

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PARP 1, 2 and 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TALAZOPARIB PARP2

Interaction Score: 1.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

PMIDs:
26652717

Sources:
ChemblInteractions
OLAPARIB PARP2

Interaction Score: 1.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PARP 1, 2 & 3 inhibitor

PMIDs:
25981132

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions
RUCAPARIB PARP2

Interaction Score: 1.07

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PARP 1, 2 and 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions PharmGKB

Ensembl: ENSG00000129484
- Version: 101_38
Alternate Names:

PARP2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9UGN5
- Version: January-2014
Alternate Names:

PARP2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.4.2.30

Publications:

RussLampel: ENSG00000129484

Version: 26-July-2011

Alternate Names:

POLY [ADP-RIBOSE] POLYMERASE-2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- RIBOSYLTRANSFERASE-2) (POLY[ADP-RIBOSE] SYNTHETASE-2) (PADPRT-2) (HPARP-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UGN5] Description

PARP2 Display Id

ENSG00000129484 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

CancerCommons: PARP2
- Version: 25-July-2013
Alternate Names:

10038 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name PARP

Publications:
HopkinsGroom: Q9UGN5
- Version: 11-September-2012
Alternate Names:

ENSG00000129484 Ensembl Gene Id

POLY [ADP-RIBOSE] POLYMERASE 2 Uniprot Protein Name

10038 Entrez Gene Id

Gene Info:

Interpro Name Poly(ADP-ribose) polymerase, catalytic domain

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR012317

Gene Categories:

DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000129484
- Version: 31-May-2017
Alternate Names:

ENSG00000129484 Gene Symbol

PARP2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: PARP2
- Version: 20-Jun-2017
Alternate Names:

10038 Entrez Gene Id

PARP2 MyCancerGenome Gene Symbol

PARP MyCancerGenome Reported Gene Name

Gene Info:

Publications:
TALC: PARP-2
- Version: 12-May-2016
Alternate Names:

PARP-2 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: ADPRT2
- Version: chembl_23
Alternate Names:

ADPRTL2 GENE_SYMBOL

PARP2 GENE_SYMBOL

Poly [ADP-ribose] polymerase 2 UNIPROT

Gene Info:

Publications:
PharmGKB: PARP2
- Version: 18-August-2020
Alternate Names:

PA24592 PharmGKB ID

Gene Info:

Publications:
GO: PARP2
- Version: 01-February-2022
Alternate Names:

ADPRT2 GO Gene Synonym

ADPRTL2 GO Gene Synonym

Gene Info:

Gene Categories:

DNA REPAIR, HISTONE MODIFICATION

Publications:
TTD: Poly [ADP-ribose] polymerase 2
- Version: 2020.06.01
Alternate Names:

PARP2 TTD Gene Abbreviation

T40812 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: PARP2
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: PARP2
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: PARP2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	PARP 1, 2 and 3 inhibitor
Direct Interaction	yes
Notes

Notes
Mechanism of Interaction	Poly [ADP-ribose] polymerase 2 inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	PARP 1, 2 & 3 inhibitor

POLY [ADP-RIBOSE] POLYMERASE-2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- RIBOSYLTRANSFERASE-2) (POLY[ADP-RIBOSE] SYNTHETASE-2) (PADPRT-2) (HPARP-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UGN5]	Description
PARP2	Display Id
ENSG00000129484	Ensembl Gene Id

10038	Entrez Gene Id
PARP2	MyCancerGenome Gene Symbol
PARP	MyCancerGenome Reported Gene Name

ADPRTL2	GENE_SYMBOL
PARP2	GENE_SYMBOL
Poly [ADP-ribose] polymerase 2	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

PARP2 Gene Record

PARP2 10038 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

VELIPARIB PARP2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction PARP 1, 2 and 3 inhibitor Direct Interaction yes Notes

PMIDs: 10592235

Sources: TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

NIRAPARIB PARP2

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions

TALAZOPARIB TOSYLATE PARP2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

PMIDs: None found

Sources: ChemblInteractions

RUCAPARIB CAMSYLATE PARP2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction PARP 1, 2 and 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TALAZOPARIB PARP2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

PMIDs: 26652717

Sources: ChemblInteractions

OLAPARIB PARP2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction PARP 1, 2 & 3 inhibitor

PMIDs: 25981132

Sources: MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

RUCAPARIB PARP2

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction PARP 1, 2 and 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions PharmGKB

Ensembl: ENSG00000129484

Alternate Names: PARP2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q9UGN5

Alternate Names: PARP2 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.4.2.30

Publications:

RussLampel: ENSG00000129484

Alternate Names: POLY [ADP-RIBOSE] POLYMERASE-2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- RIBOSYLTRANSFERASE-2) (POLY[ADP-RIBOSE] SYNTHETASE-2) (PADPRT-2) (HPARP-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UGN5] Description PARP2 Display Id ENSG00000129484 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

CancerCommons: PARP2

Alternate Names: 10038 Entrez Gene ID

Gene Info: CancerCommons Reported Gene Name PARP

Publications:

HopkinsGroom: Q9UGN5

Alternate Names: ENSG00000129484 Ensembl Gene Id POLY [ADP-RIBOSE] POLYMERASE 2 Uniprot Protein Name 10038 Entrez Gene Id

Gene Info: Interpro Name Poly(ADP-ribose) polymerase, catalytic domain Human Readable Name DRUGGABLE GENOME Interpro Acc IPR012317

Gene Categories: DRUGGABLE GENOME

Publications:

HingoraniCasas: ENSG00000129484

Alternate Names: ENSG00000129484 Gene Symbol PARP2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

MyCancerGenome: PARP2

Alternate Names: 10038 Entrez Gene Id PARP2 MyCancerGenome Gene Symbol PARP MyCancerGenome Reported Gene Name

Gene Info:

Publications:

TALC: PARP-2

Alternate Names: PARP-2 Gene Symbol

Gene Info:

Publications:

ChemblInteractions: ADPRT2

Alternate Names: ADPRTL2 GENE_SYMBOL PARP2 GENE_SYMBOL Poly [ADP-ribose] polymerase 2 UNIPROT

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PARP 1, 2 and 3 inhibitor

Direct Interaction yes

Notes

PMIDs:
10592235

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PARP 1, 2 and 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Poly [ADP-ribose] polymerase 2 inhibitor

PMIDs:
26652717

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PARP 1, 2 & 3 inhibitor

PMIDs:
25981132

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PARP 1, 2 and 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions PharmGKB

Alternate Names:

PARP2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PARP2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.4.2.30

Alternate Names:

POLY [ADP-RIBOSE] POLYMERASE-2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- RIBOSYLTRANSFERASE-2) (POLY[ADP-RIBOSE] SYNTHETASE-2) (PADPRT-2) (HPARP-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UGN5] Description

PARP2 Display Id

ENSG00000129484 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10038 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name PARP

Alternate Names:

ENSG00000129484 Ensembl Gene Id

POLY [ADP-RIBOSE] POLYMERASE 2 Uniprot Protein Name

10038 Entrez Gene Id

Gene Info:

Interpro Name Poly(ADP-ribose) polymerase, catalytic domain

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR012317

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000129484 Gene Symbol

PARP2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10038 Entrez Gene Id

PARP2 MyCancerGenome Gene Symbol

PARP MyCancerGenome Reported Gene Name

Alternate Names:

PARP-2 Gene Symbol

Alternate Names:

ADPRTL2 GENE_SYMBOL

PARP2 GENE_SYMBOL

Poly [ADP-ribose] polymerase 2 UNIPROT

Alternate Names:

PA24592 PharmGKB ID

Alternate Names:

ADPRT2 GO Gene Synonym

ADPRTL2 GO Gene Synonym

Gene Categories:

DNA REPAIR, HISTONE MODIFICATION

Alternate Names:

PARP2 TTD Gene Abbreviation

T40812 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE