5141 |
PHOSPHODIESTERASE 4A |
PDE4A |
DPDE2 |
PDE4 |
PDE46 |
600126 |
8780 |
ENSG00000065989 |
OTTHUMG00000180411 |
PHOSPHODIESTERASE 4 |
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (EC 3.1.4.17) (DPDE2) (PDE46). [SOURCE:UNIPROT/SWISSPROT;ACC:P27815] |
P27815 |
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A |
PDE4A_HUMAN |
T47941 |
T61744 |
Human Readable Name | DRUGGABLE GENOME |
Target Subclass | 3.1.4.17 |
Target Main Class | Enzymes |
Target Class | Enzymes |
Target Subclass | EC:3.1.4.17 |
Interpro Name | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
Interpro Type | Domain |
Interpro Short Name | PDEase_catalytic_dom |
Interpro Acc | IPR002073 |
Uniprot Evidence | 1: Evidence at protein level |
Uniprot Status | Swiss-Prot |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
n/a |
Trial Name | Oglemilast, GRC 3886 |
Novel drug target | Established target |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | apremilast, CC-10004 |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
n/a |
Trial Name | - |
Novel drug target | Established target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Trial Name | roflumilast, Daxas |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
Trial Name | AN-2728 |
inhibitor (inhibitory) |
Trial Name | ibudilast, MN-166, AV411 |
Novel drug target | Established target |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | ADC4022, low-dose inhaled theophylline |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | pentoxifylline, EHT0201 |
Novel drug target | Established target |
Mechanism of Interaction | 3',5'-cyclic phosphodiesterase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | 3',5'-cyclic phosphodiesterase inhibitor |
Direct Interaction | yes |
Trial Name | CRx-102, prednisolone plus dipyridamole,Synavive |
n/a |
Trial Name | EHT 0202 |
Novel drug target | Established target |
PDE4A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000065989 | Ensembl Gene Id |
5141 | Entrez Gene Id |
P27815 | Uniprot Accession |
Target Subclass | 3.1.4.17 |
Target Main Class | Enzymes |
PDE4A | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:3.1.4.17 |
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A | Uniprot Protein Name |
PDE4A | Uniprot Gene Name |
ENSG00000065989 | Ensembl Gene Id |
Interpro Name | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
Interpro Type | Domain |
Interpro Short Name | PDEase_catalytic_dom |
DRUGGABLE GENOME |
ENSG00000065989 | Ensembl Gene Id |
PDE4A | Display Id |
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A (EC 3.1.4.17) (DPDE2) (PDE46). [SOURCE:UNIPROT/SWISSPROT;ACC:P27815] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PDE4A | TTD Gene Abbreviation |
T61744 | TTD Target ID |
ENSG00000065989 | Gene Symbol |
PDE4A | Ensembl Id |
DRUGGABLE GENOME |
DPDE2 | GENE_SYMBOL |
PDE4A | GENE_SYMBOL |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | UNIPROT |
PDE4 | TTD Gene Abbreviation |
T47941 | TTD Target ID |