PDE4C Gene Record

  • DYPHYLLINE   PDE4C

    Interaction Score: 4.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Novel drug target Established target

    PMIDs:
    225216 17016423 17139284 7925603


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CRISABOROLE   PDE4C

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    22841723


    Sources:
    ChemblInteractions

  • ROFLUMILAST   PDE4C

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    17726343


    Sources:
    ChemblInteractions

  • IBUDILAST   PDE4C

    Interaction Score: 1.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ibudilast, MN-166, AV411
    Novel drug target Established target

    PMIDs:
    16313925


    Sources:
    TdgClinicalTrial

  • APREMILAST   PDE4C

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLAVOXATE HYDROCHLORIDE   PDE4C

    Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THEOPHYLLINE SODIUM GLYCINATE   PDE4C

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMINOPHYLLINE   PDE4C

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXTRIPHYLLINE   PDE4C

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLEXANOX   PDE4C

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETAZOLATE   PDE4C

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name EHT 0202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • THEOPHYLLINE   PDE4C

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Phosphodiesterase 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOXIFYLLINE   PDE4C

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIPYRIDAMOLE   PDE4C

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000105650

    • Version: 101_38

    Alternate Names:
    PDE4C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q08493

    • Version: January-2014

    Alternate Names:
    PDE4C Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.4.17

    Publications:

  • TEND: Q08493

    • Version: 01-August-2011

    Alternate Names:
    PDE4C_HUMAN Uniprot Id
    Q08493 Uniprot Accession
    ENSG00000105650 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.1.4.17

    Publications:

  • HopkinsGroom: Q08493

    • Version: 11-September-2012

    Alternate Names:
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C Uniprot Protein Name
    Q08493 Uniprot Accession
    5143 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR002073
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000105650

    • Version: 26-July-2011

    Alternate Names:
    PDE4C Display Id
    ENSG00000105650 Ensembl Gene Id
    CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4C (EC 3.1.4.17) (DPDE1) (PDE21). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08493] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000105650

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105650 Gene Symbol
    PDE4C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: DPDE1

    • Version: chembl_23

    Alternate Names:
    DPDE1 GENE_SYMBOL
    PDE4C GENE_SYMBOL
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C UNIPROT

    Gene Info:

    Publications:

  • TTD: Phosphodiesterase 4C

    • Version: 2020.06.01

    Alternate Names:
    PDE4C TTD Gene Abbreviation
    T12081 TTD Target ID

    Gene Info:

    Publications: