DGIdb - PDE4D Gene Record

PDE4D 5144 Druggable Genome

Alternate Names:

5144
PHOSPHODIESTERASE 4D
PDE4D
ACRDYS2
DPDE3
HSPDE4D
PDE43
PDE4DN2
STRK1
600129
8783
ENSG00000113448
OTTHUMG00000162218
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499
PDE4D_HUMAN
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (EC 3.1.4.17) (DPDE3) (PDE43). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08499]
PA33130
T02001

Gene Info:

Interpro Type	Domain
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Name	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Interpro Acc	IPR002073
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	PDEase_catalytic_dom
Target Class	Enzymes
Target Subclass	EC:3.1.4.17
Target Subclass	3.1.4.17
Target Main Class	Enzymes
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Freund YR et al., 2012, Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center., FEBS Lett
Barone et al., 2008, Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice., Pharmacology
Hariton, 1994, Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors., Eur. J. Pharmacol.
Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol
Beeh et al., 2004, Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients., Lung
Bäumer et al., 2007, Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis., Inflamm Allergy Drug Targets
Abdulrahim et al., 2015, Apremilast: a PDE4 inhibitor for the treatment of psoriatic arthritis., Expert Opin Pharmacother

PICLAMILAST PDE4D

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 15765929

Sources:
TTD
BPN-14770 PDE4D

Interaction Score: 2.21

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

PMIDs:
None found

Sources:
TTD
DYPHYLLINE PDE4D

Interaction Score: 1.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND
ROLIPRAM PDE4D

Interaction Score: 1.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 17016423 17139284

Sources:
TTD
ROFLUMILAST PDE4D

Interaction Score: 1.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
10592235 17726343

Sources:
ChemblInteractions
OGLEMILAST PDE4D

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18660832

Sources:
TTD
APREMILAST PDE4D

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
17352685 25864487

Sources:
ChemblInteractions
CRISABOROLE PDE4D

Interaction Score: 1.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
22841723

Sources:
ChemblInteractions
TOFIMILAST PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MK-0873 PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GSK-356278 PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DENBUFYLLINE PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
REVAMILAST PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HT-0712 PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LIRIMILAST PDE4D

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CDC-801 PDE4D

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FLAVOXATE HYDROCHLORIDE PDE4D

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE4D

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE SODIUM GLYCINATE PDE4D

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4D

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLEXANOX PDE4D

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PAPAVERINE PDE4D

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ETAZOLATE PDE4D

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EHT 0202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
THEOPHYLLINE PDE4D

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUETIAPINE PDE4D

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PENTOXIFYLLINE PDE4D

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RESVERATROL PDE4D

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resveratrol

Novel drug target Established target

Trial Name SRT501

PMIDs:
None found

Sources:
TdgClinicalTrial
DIPYRIDAMOLE PDE4D

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000113448
- Version: 101_38
Alternate Names:

PDE4D Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000113448
- Version: 26-July-2011
Alternate Names:

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (EC 3.1.4.17) (DPDE3) (PDE43). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08499] Description

ENSG00000113448 Ensembl Gene Id

PDE4D Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: Q08499
- Version: 01-August-2011
Alternate Names:

PDE4D_HUMAN Uniprot Id

Q08499 Uniprot Accession

ENSG00000113448 Ensembl Gene Id

Gene Info:

Target Subclass 3.1.4.17

Target Main Class Enzymes

Publications:
TdgClinicalTrial: Q08499
- Version: January-2014
Alternate Names:

PDE4D Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.4.17

Publications:
HopkinsGroom: Q08499
- Version: 11-September-2012
Alternate Names:

PDE4D Uniprot Gene Name

5144 Entrez Gene Id

ENSG00000113448 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: PDE4D

Version: 18-August-2020

Alternate Names:

PA33130 PharmGKB ID

Gene Info:

Publications:

Anthony EG et al., 2013, Association of phosphodiesterase 4 polymorphism (rs702553) with blood pressure in the African American Study of Kidney Disease and Hypertension Genomics Study., Pharmacogenet Genomics

TTD: Phosphodiesterase 4D

Version: 2020.06.01

Alternate Names:

PDE4D TTD Gene Abbreviation

T02001 TTD Target ID

Gene Info:

Publications:

Stocchi F, 2014, Therapy for Parkinson's disease: what is in the pipeline?, Neurotherapeutics

Giembycz MA, 2008, Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?, Br J Pharmacol

HingoraniCasas: ENSG00000113448
- Version: 31-May-2017
Alternate Names:

ENSG00000113448 Gene Symbol

PDE4D Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: DPDE3
- Version: chembl_23
Alternate Names:

DPDE3 GENE_SYMBOL

PDE4D GENE_SYMBOL

cAMP-specific 3',5'-cyclic phosphodiesterase 4D UNIPROT

Gene Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Phosphodiesterase 4 inhibitor

Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Direct Interaction	yes

Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor
Direct Interaction	yes

Trial Name	Resveratrol
Novel drug target	Established target
Trial Name	SRT501

CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (EC 3.1.4.17) (DPDE3) (PDE43). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08499]	Description
ENSG00000113448	Ensembl Gene Id
PDE4D	Display Id

PDE4D_HUMAN	Uniprot Id
Q08499	Uniprot Accession
ENSG00000113448	Ensembl Gene Id

PDE4D	Uniprot Gene Name
5144	Entrez Gene Id
ENSG00000113448	Ensembl Gene Id

DPDE3	GENE_SYMBOL
PDE4D	GENE_SYMBOL
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

PDE4D Gene Record

PDE4D 5144 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 15765929

Sources: TTD

Interaction Types & Directionality: allosteric modulator

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs: 17016423 17139284 7925603

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 17016423 17139284

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 10592235 17726343

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18660832

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 17352685 25864487

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 22841723

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
10592235 15765929

Sources:
TTD

Interaction Types & Directionality:

allosteric modulator

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Phosphodiesterase 4 inhibitor

PMIDs:
17016423 17139284 7925603

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 17016423 17139284

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
10592235 17726343

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18660832

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
17352685 25864487

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
22841723

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EHT 0202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)