PLCG2 Gene Record

  • PLCG2 5336 Druggable GenomeClinically Actionable

    Alternate Names:

    5336
    PHOSPHOLIPASE C GAMMA 2
    PLCG2
    APLAID
    FCAS3
    PLC-IV
    PLC-gamma-2
    600220
    9066
    ENSG00000197943
    OTTHUMG00000176532
    PLCG2_HUMAN
    P16885
    1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
    1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA 2 (EC 3.1.4.11) (PHOSPHOINOSITIDE PHOSPHOLIPASE C) (PLC-GAMMA-2) (PHOSPHOLIPASE C-GAMMA-2) (PLC-IV). [SOURCE:UNIPROT/SWISSPROT;ACC:P16885]

    Gene Info:

    Interpro Name Phosphoinositide phospholipase C
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Acc IPR001192
    Human Readable Name PHOSPHOLIPASE
    Interpro Short Name Pinositol_PLipase_C
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    PHOSPHOLIPASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

  • IBRUTINIB   PLCG2

    Interaction Score: 9.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Clinical Status early trials
    Pathway activation
    Variant Effect gain-of-function

    PMIDs:
    24869598


    Sources:
    DoCM

  • Ensembl: ENSG00000197943

    • Version: 101_38

    Alternate Names:
    PLCG2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P16885

    • Version: 11-September-2012

    Alternate Names:
    P16885 Uniprot Accession
    ENSG00000197943 Ensembl Gene Id
    PLCG2 Uniprot Gene Name

    Gene Info:
    Interpro Name Phosphoinositide phospholipase C
    Uniprot Status Swiss-Prot
    Interpro Type Family

    Gene Categories:
    PHOSPHOLIPASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000197943

    • Version: 26-July-2011

    Alternate Names:
    1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA 2 (EC 3.1.4.11) (PHOSPHOINOSITIDE PHOSPHOLIPASE C) (PLC-GAMMA-2) (PHOSPHOLIPASE C-GAMMA-2) (PLC-IV). [SOURCE:UNIPROT/SWISSPROT;ACC:P16885] Description
    PLCG2 Display Id
    ENSG00000197943 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DoCM: PLCG2

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Woyach et al., 2014, Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib., N. Engl. J. Med.

  • HingoraniCasas: ENSG00000197943

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000197943 Gene Symbol
    PLCG2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: PLCG2

    • Version: 19.3

    Alternate Names:
    ENSG00000197943 Ensembl Gene ID
    Phospholipase C gamma 2 Human Protein Atlas Gene Description
    P16885 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: PLCG2

    • Version: 11-November-2018

    Alternate Names:
    PLCG2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: PLCG2

    • Version: 01-February-2022

    Alternate Names:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Gene Name
    P16885 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • FoundationOneGenes: PLCG2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: