5422 |
DNA POLYMERASE ALPHA 1, CATALYTIC SUBUNIT |
POLA1 |
NSX |
POLA |
p180 |
312040 |
9173 |
ENSG00000101868 |
OTTHUMG00000021277 |
P09884 |
DPOLA_HUMAN |
DNA polymerase alpha catalytic subunit |
DNA polymerase alpha catalytic subunit p180 |
DNA POLYMERASE ALPHA CATALYTIC SUBUNIT (EC 2.7.7.7). [SOURCE:UNIPROT/SWISSPROT;ACC:P09884] |
VEODS |
Target Subclass | 2.7.7.7 |
Target Main Class | Enzymes |
Target Class | Enzymes |
Target Subclass | EC:2.7.7.7 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | DNA-dir_DNA_pol_B_multi_dom |
Interpro Short Name | DNA-dir_DNA_pol_B_exonuc |
Interpro Name | DNA-directed DNA polymerase, family B, multifunctional domain |
Interpro Type | Domain |
Interpro Acc | IPR006134 |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR006133 |
Interpro Name | DNA-directed DNA polymerase, family B |
Interpro Type | Family |
Interpro Name | DNA-directed DNA polymerase, family B, exonuclease domain |
Interpro Short Name | DNA-dir_DNA_pol_B |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | DNA DIRECTED DNA POLYMERASE |
Interpro Acc | IPR006172 |
Gene Biotype | PROTEIN_CODING |
DNA REPAIR |
DRUGGABLE GENOME |
DNA DIRECTED RNA POLYMERASE |
inhibitor (inhibitory) |
Trial Name | nelarabine, GW-506U78,Arranon, Atriance |
Novel drug target | Established target |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | Clofarabine |
Mechanism of Interaction | DNA polymerase (alpha/delta/epsilon) inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA polymerase (alpha/delta/epsilon) inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA polymerase (alpha/delta/epsilon) inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA polymerase (alpha/delta/epsilon) inhibitor |
Direct Interaction | yes |
POLA1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
DNA POLYMERASE ALPHA CATALYTIC SUBUNIT (EC 2.7.7.7). [SOURCE:UNIPROT/SWISSPROT;ACC:P09884] | Description |
ENSG00000101868 | Ensembl Gene Id |
POLA | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
POLA1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.7.7 |
P09884 | Uniprot Accession |
5422 | Entrez Gene Id |
ENSG00000101868 | Ensembl Gene Id |
Target Subclass | 2.7.7.7 |
Target Main Class | Enzymes |
P09884 | Uniprot Accession |
DNA POLYMERASE ALPHA CATALYTIC SUBUNIT | Uniprot Protein Name |
ENSG00000101868 | Ensembl Gene Id |
Interpro Short Name | DNA-dir_DNA_pol_B_multi_dom |
Interpro Short Name | DNA-dir_DNA_pol_B_exonuc |
Interpro Name | DNA-directed DNA polymerase, family B, multifunctional domain |
DNA DIRECTED RNA POLYMERASE |
ENSG00000101868 | Gene Symbol |
POLA1 | Ensembl Id |
DRUGGABLE GENOME |
POLA | GENE_SYMBOL |
POLA1 | GENE_SYMBOL |
DNA polymerase alpha catalytic subunit | UNIPROT |
POLA | GO Gene Synonym |
DNA REPAIR |