DGIdb - PRKCD Gene Record

PRKCD 5580 Druggable Genome

Alternate Names:

5580
PROTEIN KINASE C DELTA
PRKCD
ALPS3
CVID9
MAY1
PKCD
nPKC-delta
176977
9399
ENSG00000163932
OTTHUMG00000133659
SDK1
Protein kinase C delta type regulatory subunit
Protein kinase C delta type catalytic subunit
Tyrosine-protein kinase PRKCD
Sphingosine-dependent protein kinase-1
Protein kinase C delta type
Q05655
KPCD_HUMAN
PROTEIN KINASE C, DELTA TYPE (EC 2.7.1.-) (NPKC-DELTA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05655]
PKC
T44861

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Acc	IPR002290
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
Target Class	Enzymes
Target Subclass	EC:2.7.11.13
Initial Gene Query	PKC delta
Counted Citations from 1950-2000	1336
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem
Messing et al., 1991, Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells., J. Biol. Chem.
Song J et al., 2014, Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells., Bioorg Med Chem Lett
Lin W et al., 2012, Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation., Eur J Med Chem
Pagani A et al., 2010, Synthesis and biological evaluation of 12-aminoacylphorboids., J Nat Prod
Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett

DELCASERTIB PRKCD

Interaction Score: 6.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name KAI-9803

Novel drug target Established target

Mechanism of Interaction Protein kinase C delta inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
TETRADECANOYL PHORBOL ACETATE PRKCD

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20121237

Sources:
DTC
PHORBOL MYRISTATE ACETATE PRKCD

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
CHEMBL27768 PRKCD

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
BRYOSTATIN PRKCD

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial
ENOXOLONE PRKCD

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24461294

Sources:
DTC
ROTTLERIN PRKCD

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22093759

Sources:
DTC
DIMETHYLADENINE PRKCD

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-690693 PRKCD

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEP-2563 PRKCD

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
UCN-01 PRKCD

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL578061 PRKCD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MIDOSTAURIN PRKCD

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
LY-2090314 PRKCD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE PRKCD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FASUDIL PRKCD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SNS-314 PRKCD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALCOHOL PRKCD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1744136

Sources:
NCI
GO-6976 PRKCD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A PRKCD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE PRKCD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN PRKCD

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL225519 PRKCD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN PRKCD

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
RG-1530 PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB PRKCD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000163932
- Version: 101_38
Alternate Names:

PRKCD Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: PRKCD
- Version: February-2014
Alternate Names:

5580 Entrez Gene ID

Gene Info:

Initial Gene Query PKC delta

Counted Citations from 1950-2000 1336

Gene Categories:

KINASE

Publications:
TdgClinicalTrial: Q05655
- Version: January-2014
Alternate Names:

PRKCD Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Publications:
RussLampel: ENSG00000163932
- Version: 26-July-2011
Alternate Names:

PRKCD Display Id

ENSG00000163932 Ensembl Gene Id

PROTEIN KINASE C, DELTA TYPE (EC 2.7.1.-) (NPKC-DELTA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05655] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q05655
- Version: 11-September-2012
Alternate Names:

ENSG00000163932 Ensembl Gene Id

PRKCD Uniprot Gene Name

KPCD_HUMAN Uniprot Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
NCI: PRKCD
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Messing et al., 1991, Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells., J. Biol. Chem.

DTC: PRKCD

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem

Lin W et al., 2012, Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation., Eur J Med Chem

Pagani A et al., 2010, Synthesis and biological evaluation of 12-aminoacylphorboids., J Nat Prod

MyCancerGenome: PRKCD
- Version: 20-Jun-2017
Alternate Names:

5580 Entrez Gene Id

PRKCD MyCancerGenome Gene Symbol

PKC MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000163932
- Version: 31-May-2017
Alternate Names:

ENSG00000163932 Gene Symbol

PRKCD Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PRKCD
- Version: chembl_23
Alternate Names:

SDK1 UNIPROT

PRKCD GENE_SYMBOL

Protein kinase C delta type UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: PRKCD
- Version: 19.3
Alternate Names:

ENSG00000163932 Ensembl Gene ID

Protein kinase C delta Human Protein Atlas Gene Description

Q05655 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: PRKCD
- Version: 01-February-2022
Alternate Names:

PKCD GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: PRKCD
- Version: 27-Jun-2013
Alternate Names:

5580 Gene ID

MAY1 dGene Synonym

PKCD dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Protein kinase C delta
- Version: 2020.06.01
Alternate Names:

PRKCD TTD Gene Abbreviation

T44861 TTD Target ID

Gene Info:

Publications:
Pharos: PRKCD
- Version: 01-February-2022
Alternate Names:

Protein kinase C delta type Gene Name

Q05655 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:

Trial Name	KAI-9803
Novel drug target	Established target
Mechanism of Interaction	Protein kinase C delta inhibitor

Mechanism of Interaction	Protein kinase C (PKC) inhibitor
Direct Interaction	yes

PRKCD	Display Id
ENSG00000163932	Ensembl Gene Id
PROTEIN KINASE C, DELTA TYPE (EC 2.7.1.-) (NPKC-DELTA). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05655]	Description

5580	Entrez Gene Id
PRKCD	MyCancerGenome Gene Symbol
PKC	MyCancerGenome Reported Gene Name

SDK1	UNIPROT
PRKCD	GENE_SYMBOL
Protein kinase C delta type	UNIPROT

PRKCD Gene Record

PRKCD 5580 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name KAI-9803 Novel drug target Established target Mechanism of Interaction Protein kinase C delta inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20121237

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Bryostatin Novel drug target Established target

PMIDs: 22579485

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24461294

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22093759

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1744136

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name KAI-9803

Novel drug target Established target

Mechanism of Interaction Protein kinase C delta inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
20121237

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24461294

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22093759

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
1744136

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

n/a