DGIdb - PSEN1 Gene Record

PSEN1 5663 Druggable Genome

Alternate Names:

5663
PRESENILIN 1
PSEN1
AD3
FAD
PS-1
PS1
S182
104311
9508
ENSG00000080815
OTTHUMG00000141279
P49768
PSNL1
Presenilin-1 NTF subunit
PS1-CTF12
Protein S182
Presenilin-1 CTF12
Presenilin-1 CTF subunit
Presenilin-1
Gamma-secretase
P46976
T93105
ACNINV3

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.4.23.-
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem
Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem
Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

SEMAGACESTAT PSEN1

Interaction Score: 4.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

Trial Name LY-450139

PMIDs:
19443228

Sources:
DTC TdgClinicalTrial ChemblInteractions
CHEMBL392068 PSEN1

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23181502 19443228

Sources:
DTC
IC261 PSEN1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20350806

Sources:
DTC
AVAGACESTAT PSEN1

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name BMS-708163

Novel drug target Novel Target

Mechanism of Interaction Gamma-secretase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
BEGACESTAT PSEN1

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GSI-136 PSEN1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL247471 PSEN1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-299897

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TARENFLURBIL PSEN1

Interaction Score: 0.86

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Gamma-secretase modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000080815
- Version: 101_38
Alternate Names:

PSEN1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P46976
- Version: January-2014
Alternate Names:

PSEN1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.-

Publications:
TdgClinicalTrial: P49768
- Version: January-2014
Alternate Names:

PSEN1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.-

Publications:
NCI: PSEN1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Satoh et al., 1999, Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines., Neuropathol. Appl. Neurobiol.

DTC: PSEN1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem

Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem

MyCancerGenome: PSEN1
- Version: 20-Jun-2017
Alternate Names:

5663 Entrez Gene Id

PSEN1 MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000080815
- Version: 31-May-2017
Alternate Names:

ENSG00000080815 Gene Symbol

PSEN1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: PSEN1
- Version: 12-May-2016
Alternate Names:

PSEN1 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: AD3
- Version: chembl_23
Alternate Names:

PS1 GENE_SYMBOL

PSNL1 GENE_SYMBOL

PSEN1 GENE_SYMBOL

Gene Info:

Publications:
HumanProteinAtlas: PSEN1
- Version: 19.3
Alternate Names:

ENSG00000080815 Ensembl Gene ID

AD3 Human Protein Atlas Gene Synonym

FAD Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER, ENZYME

Publications:
GO: PSEN1
- Version: 01-February-2022
Alternate Names:

AD3 GO Gene Synonym

PS1 GO Gene Synonym

PSNL1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
dGene: PSEN1
- Version: 27-Jun-2013
Alternate Names:

5663 Gene ID

AD3 dGene Synonym

FAD dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Presenilin 1
- Version: 2020.06.01
Alternate Names:

PSEN1 TTD Gene Abbreviation

T93105 TTD Target ID

Gene Info:

Publications:
Pharos: PSEN1
- Version: 01-February-2022
Alternate Names:

Presenilin-1 Gene Name

P49768 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Mechanism of Interaction	Gamma-secretase inhibitor
Direct Interaction	yes
Trial Name	LY-450139

Trial Name	BMS-708163
Novel drug target	Novel Target
Mechanism of Interaction	Gamma-secretase inhibitor

Mechanism of Interaction	Gamma-secretase modulator
Direct Interaction	yes

5663	Entrez Gene Id
PSEN1	MyCancerGenome Gene Symbol
Gamma-secretase	MyCancerGenome Reported Gene Name

ENSG00000080815	Ensembl Gene ID
AD3	Human Protein Atlas Gene Synonym
FAD	Human Protein Atlas Gene Synonym

PSEN1 Gene Record

PSEN1 5663 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Gamma-secretase inhibitor Direct Interaction yes Trial Name LY-450139

PMIDs: 19443228

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23181502 19443228

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20350806

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name BMS-708163 Novel drug target Novel Target Mechanism of Interaction Gamma-secretase inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Gamma-secretase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GSI-136 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-299897 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Gamma-secretase modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000080815

Alternate Names: PSEN1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P46976

Alternate Names: PSEN1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.23.-

Publications:

TdgClinicalTrial: P49768

Alternate Names: PSEN1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.23.-

Publications:

NCI: PSEN1

Alternate Names:

Gene Info:

Publications: Satoh et al., 1999, Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines., Neuropathol. Appl. Neurobiol.

DTC: PSEN1

Alternate Names:

Gene Info:

MyCancerGenome: PSEN1

Alternate Names: 5663 Entrez Gene Id PSEN1 MyCancerGenome Gene Symbol Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:

HingoraniCasas: ENSG00000080815

Alternate Names: ENSG00000080815 Gene Symbol PSEN1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TALC: PSEN1

Alternate Names: PSEN1 Gene Symbol

Gene Info:

Publications:

ChemblInteractions: AD3

Alternate Names: PS1 GENE_SYMBOL PSNL1 GENE_SYMBOL PSEN1 GENE_SYMBOL

Gene Info:

Publications:

HumanProteinAtlas: PSEN1

Alternate Names: ENSG00000080815 Ensembl Gene ID AD3 Human Protein Atlas Gene Synonym FAD Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: TRANSPORTER, ENZYME

Publications:

GO: PSEN1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

Trial Name LY-450139

PMIDs:
19443228

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23181502 19443228

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20350806

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name BMS-708163

Novel drug target Novel Target

Mechanism of Interaction Gamma-secretase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-299897

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Gamma-secretase modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PSEN1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PSEN1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.-

Alternate Names:

PSEN1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.-

Publications:

Satoh et al., 1999, Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines., Neuropathol. Appl. Neurobiol.

Alternate Names:

5663 Entrez Gene Id

PSEN1 MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Alternate Names:

ENSG00000080815 Gene Symbol

PSEN1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PSEN1 Gene Symbol

Alternate Names:

PS1 GENE_SYMBOL

PSNL1 GENE_SYMBOL

PSEN1 GENE_SYMBOL

Alternate Names:

ENSG00000080815 Ensembl Gene ID

AD3 Human Protein Atlas Gene Synonym

FAD Human Protein Atlas Gene Synonym

Gene Categories:

TRANSPORTER, ENZYME

Alternate Names:

AD3 GO Gene Synonym

PS1 GO Gene Synonym

PSNL1 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

5663 Gene ID

AD3 dGene Synonym

FAD dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

PSEN1 TTD Gene Abbreviation

T93105 TTD Target ID

Alternate Names:

Presenilin-1 Gene Name

P49768 UniProt ID

Gene Categories:

ENZYME