DGIdb - PTK2 Gene Record

PTK2 5747 Druggable Genome

Alternate Names:

5747
PROTEIN TYROSINE KINASE 2
PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
600758
9611
ENSG00000169398
OTTHUMG00000067438
Q05397
FOCAL ADHESION KINASE 1 (EC 2.7.1.112) (FADK 1) (PP125FAK) (PROTEIN- TYROSINE KINASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05397]
Focal adhesion kinase-related nonkinase
Focal adhesion kinase 1
Protein phosphatase 1 regulatory subunit 71
Protein-tyrosine kinase 2
FADK 1
FAK1_HUMAN
T15068

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Human Readable Name	KINASE
Interpro Type	Domain
Interpro Acc	IPR001245
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Uniprot Status	Swiss-Prot
CancerCommons Reported Gene Name	FAK, PYK2
Gene Biotype	PROTEIN_CODING

(13 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME
ENZYME

Publications:

Iwatani M et al., 2013, Discovery and characterization of novel allosteric FAK inhibitors., Eur J Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Golubovskaya VM et al., 2008, A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth., J Med Chem
Kurenova et al., 2009, Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo., J. Med. Chem.

BI-853520 PTK2

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL2333445 PTK2

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22819505

Sources:
DTC
VS-4718 PTK2

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHLORPYRAMIN HYDROCHLORIDE PTK2

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19610651

Sources:
DTC
CHEMBL456559 PTK2

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18989950

Sources:
DTC
DEFACTINIB HYDROCHLORIDE PTK2

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CEP-37440 PTK2

Interaction Score: 2.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
GSK-2256098 PTK2

Interaction Score: 2.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
DEFACTINIB PTK2

Interaction Score: 2.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name PF-04554878

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
MASITINIB PTK2

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
ENMD-2076 PTK2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ENMD-2076

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PF-00562271 PTK2

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Notes

PMIDs:
None found

Sources:
TALC DTC ChemblInteractions TTD
MLN-8054 PTK2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ADAVOSERTIB PTK2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X PTK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HESPERADIN PTK2

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
PAZOPANIB PTK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALISERTIB PTK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SNS-314 PTK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1997335 PTK2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 PTK2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB PTK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB PTK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 PTK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 PTK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB PTK2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000169398
- Version: 101_38
Alternate Names:

PTK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q05397
- Version: January-2014
Alternate Names:

PTK2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:
CancerCommons: PTK2
- Version: 25-July-2013
Alternate Names:

5747 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name FAK, PYK2

Publications:

RussLampel: ENSG00000169398

Version: 26-July-2011

Alternate Names:

PTK2 Display Id

ENSG00000169398 Ensembl Gene Id

FOCAL ADHESION KINASE 1 (EC 2.7.1.112) (FADK 1) (PP125FAK) (PROTEIN- TYROSINE KINASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05397] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q05397
- Version: 11-September-2012
Alternate Names:

FOCAL ADHESION KINASE 1 Uniprot Protein Name

Q05397 Uniprot Accession

PTK2 Uniprot Gene Name

Gene Info:

Human Readable Name KINASE

Interpro Type Domain

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

NCI: PTK2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Tsuchida et al., 1999, T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+., J. Immunol.

DTC: PTK2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Kurenova et al., 2009, Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo., J. Med. Chem.

Iwatani M et al., 2013, Discovery and characterization of novel allosteric FAK inhibitors., Eur J Med Chem

TALC: FAK
- Version: 12-May-2016
Alternate Names:

FAK Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000169398
- Version: 31-May-2017
Alternate Names:

ENSG00000169398 Gene Symbol

PTK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: PTK2
- Version: 20-Jun-2017
Alternate Names:

5747 Entrez Gene Id

PTK2 MyCancerGenome Gene Symbol

FAK MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: FAK
- Version: chembl_23
Alternate Names:

FAK1 GENE_SYMBOL

PTK2 GENE_SYMBOL

Focal adhesion kinase 1 UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: PTK2
- Version: 19.3
Alternate Names:

ENSG00000169398 Ensembl Gene ID

FADK Human Protein Atlas Gene Synonym

FAK Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: PTK2
- Version: 01-February-2022
Alternate Names:

FAK GO Gene Synonym

FAK1 GO Gene Synonym

Gene Info:

Gene Categories:

TYROSINE KINASE

Publications:
dGene: PTK2
- Version: 27-Jun-2013
Alternate Names:

5747 Gene ID

FADK dGene Synonym

FAK dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Focal adhesion kinase 1
- Version: 2020.06.01
Alternate Names:

FAK TTD Gene Abbreviation

T15068 TTD Target ID

Gene Info:

Publications:
Pharos: PTK2
- Version: 01-February-2022
Alternate Names:

Focal adhesion kinase 1 Gene Name

Q05397 UniProt ID

Gene Info:

Gene Categories:

KINASE, G PROTEIN COUPLED RECEPTOR

Publications:
ClearityFoundationClinicalTrial: PTK2
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Focal adhesion kinase 1 inhibitor
Direct Interaction	yes

Novel drug target	Novel Target
Trial Name	PF-04554878
Mechanism of Interaction	Focal adhesion kinase 1 inhibitor

PTK2	Display Id
ENSG00000169398	Ensembl Gene Id
FOCAL ADHESION KINASE 1 (EC 2.7.1.112) (FADK 1) (PP125FAK) (PROTEIN- TYROSINE KINASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05397]	Description

FOCAL ADHESION KINASE 1	Uniprot Protein Name
Q05397	Uniprot Accession
PTK2	Uniprot Gene Name

5747	Entrez Gene Id
PTK2	MyCancerGenome Gene Symbol
FAK	MyCancerGenome Reported Gene Name

FAK1	GENE_SYMBOL
PTK2	GENE_SYMBOL
Focal adhesion kinase 1	UNIPROT

PTK2 Gene Record

PTK2 5747 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Focal adhesion kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22819505

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Focal adhesion kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19610651

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18989950

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Focal adhesion kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Focal adhesion kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name PF-04554878 Mechanism of Interaction Focal adhesion kinase 1 inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ENMD-2076 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Focal adhesion kinase 1 inhibitor Notes

PMIDs: None found

Sources: TALC DTC ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
22819505

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
19610651

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18989950

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name PF-04554878

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ENMD-2076

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Focal adhesion kinase 1 inhibitor

Notes

PMIDs:
None found

Sources:
TALC DTC ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a