DGIdb - RAMP2 Gene Record

RAMP2 10266 Druggable Genome

Alternate Names:

10266
RECEPTOR ACTIVITY MODIFYING PROTEIN 2
RAMP2
605154
9844
ENSG00000131477
OTTHUMG00000180648
O60895
RAMP2_HUMAN
CRLR activity-modifying protein 2
Calcitonin-receptor-like receptor activity-modifying protein 2
Receptor activity-modifying protein 2

Gene Info:

Target Subclass	Other_receptors
Target Subclass	RAMP
Target Main Class	Receptors
Transmembrane Helix Count	1
Target Class	Receptors
Target Subclass	Receptors
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Qi et al., 2010, Structure-function relationships of the N-terminus of receptor activity-modifying proteins., Br. J. Pharmacol.
Qi et al., 2008, Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function., Mol. Pharmacol.
Hay et al., 2004, Amylin receptors: molecular composition and pharmacology., Biochem. Soc. Trans.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Roth et al., 2009, Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications., Arch. Neurol.

PRAMLINTIDE RAMP2

Interaction Score: 49.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 18593822 15494035 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND
PRAMLINTIDE ACETATE RAMP2

Interaction Score: 7.73

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Amylin receptor AMY2; CALCR/RAMP2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000131477
- Version: 101_38
Alternate Names:

RAMP2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: O60895
- Version: 01-August-2011
Alternate Names:

RAMP2_HUMAN Uniprot Id

10266 Entrez Gene Id

O60895 Uniprot Accession

Gene Info:

Target Subclass Other_receptors

Target Subclass RAMP

Target Main Class Receptors

Publications:
TdgClinicalTrial: O60895
- Version: January-2014
Alternate Names:

RAMP2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass RAMP

Publications:
ChemblInteractions: RAMP2
- Version: chembl_23
Alternate Names:

RAMP2 GENE_SYMBOL

Receptor activity-modifying protein 2 UNIPROT

Calcitonin-receptor-like receptor activity-modifying protein 2 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000131477
- Version: 31-May-2017
Alternate Names:

ENSG00000131477 Gene Symbol

RAMP2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: RAMP2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Mechanism of Interaction	Amylin receptor AMY2; CALCR/RAMP2 agonist
Direct Interaction	yes

RAMP2_HUMAN	Uniprot Id
10266	Entrez Gene Id
O60895	Uniprot Accession

RAMP2	GENE_SYMBOL
Receptor activity-modifying protein 2	UNIPROT
Calcitonin-receptor-like receptor activity-modifying protein 2	UNIPROT

Trial Name	Symlin
Novel drug target	Established target

RAMP2 Gene Record

RAMP2 10266 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PRAMLINTIDE RAMP2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Symlin Novel drug target Established target

PMIDs: 20015292 18593822 15494035 17016423 17139284 19273748

Sources: TdgClinicalTrial TEND

PRAMLINTIDE ACETATE RAMP2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Amylin receptor AMY2; CALCR/RAMP2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000131477

Alternate Names: RAMP2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: O60895

Alternate Names: RAMP2_HUMAN Uniprot Id 10266 Entrez Gene Id O60895 Uniprot Accession

Gene Info: Target Subclass Other_receptors Target Subclass RAMP Target Main Class Receptors

Publications:

TdgClinicalTrial: O60895

Alternate Names: RAMP2 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass RAMP

Publications:

ChemblInteractions: RAMP2

Alternate Names: RAMP2 GENE_SYMBOL Receptor activity-modifying protein 2 UNIPROT Calcitonin-receptor-like receptor activity-modifying protein 2 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000131477

Alternate Names: ENSG00000131477 Gene Symbol RAMP2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: RAMP2

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Symlin

Novel drug target Established target

PMIDs:
20015292 18593822 15494035 17016423 17139284 19273748

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Amylin receptor AMY2; CALCR/RAMP2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

RAMP2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

RAMP2_HUMAN Uniprot Id

10266 Entrez Gene Id

O60895 Uniprot Accession

Gene Info:

Target Subclass Other_receptors

Target Subclass RAMP

Target Main Class Receptors

Alternate Names:

RAMP2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass RAMP

Alternate Names:

RAMP2 GENE_SYMBOL

Receptor activity-modifying protein 2 UNIPROT

Calcitonin-receptor-like receptor activity-modifying protein 2 UNIPROT

Alternate Names:

ENSG00000131477 Gene Symbol

RAMP2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Gene Categories:

CELL SURFACE