RPS6KA4 Gene Record

  • RPS6KA4 8986 Druggable GenomeClinically Actionable

    Alternate Names:

    8986
    RIBOSOMAL PROTEIN S6 KINASE A4
    RPS6KA4
    MSK2
    RSK-B
    S6K-alpha-4
    603606
    10433
    ENSG00000162302
    OTTHUMG00000046094
    O75676
    KS6A4_HUMAN
    RIBOSOMAL PROTEIN S6 KINASE ALPHA 4 (EC 2.7.1.37) (NUCLEAR MITOGEN-AND STRESS-ACTIVATED PROTEIN KINASE-2) (90 KDA RIBOSOMAL PROTEIN S6 KINASE 4) (RIBOSOMAL PROTEIN KINASE B) (RSKB). [SOURCE:UNIPROT/SWISSPROT;ACC:O75676]
    RIBOSOMAL PROTEIN S6 KINASE ALPHA-4

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

  • HESPERADIN   RPS6KA4

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • LINIFANIB   RPS6KA4

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000162302

    • Version: 101_38

    Alternate Names:
    RPS6KA4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000162302

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000162302 Ensembl Gene Id
    RPS6KA4 Display Id
    RIBOSOMAL PROTEIN S6 KINASE ALPHA 4 (EC 2.7.1.37) (NUCLEAR MITOGEN-AND STRESS-ACTIVATED PROTEIN KINASE-2) (90 KDA RIBOSOMAL PROTEIN S6 KINASE 4) (RIBOSOMAL PROTEIN KINASE B) (RSKB). [SOURCE:UNIPROT/SWISSPROT;ACC:O75676] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: O75676

    • Version: 11-September-2012

    Alternate Names:
    RPS6KA4 Uniprot Gene Name
    8986 Entrez Gene Id
    O75676 Uniprot Accession

    Gene Info:
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Interpro Acc IPR002290

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • DTC: RPS6KA4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

  • HingoraniCasas: ENSG00000162302

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000162302 Gene Symbol
    RPS6KA4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: RPS6KA4

    • Version: 01-February-2022

    Alternate Names:
    MSK2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: RPS6KA4

    • Version: 27-Jun-2013

    Alternate Names:
    8986 Gene ID
    MSK2 dGene Synonym
    RSK-B dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: RPS6KA4

    • Version: 01-February-2022

    Alternate Names:
    Ribosomal protein S6 kinase alpha-4 Gene Name
    O75676 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: RPS6KA4

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: