DGIdb - RPS6KB1 Gene Record

RPS6KB1 6198 Druggable Genome

Alternate Names:

6198
RIBOSOMAL PROTEIN S6 KINASE B1
RPS6KB1
PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70 S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
608938
10436
ENSG00000108443
OTTHUMG00000150642
P23443
KS6B1_HUMAN
RIBOSOMAL PROTEIN S6 KINASE BETA-1
RIBOSOMAL PROTEIN S6 KINASE
p70 S6 kinase alpha
p70-S6K 1
Serine/threonine-protein kinase 14A
p70 S6K-alpha
P70S6K1
70 kDa ribosomal protein S6 kinase 1
Ribosomal protein S6 kinase I
p70 ribosomal S6 kinase alpha
RIBOSOMAL PROTEIN S6 KINASE 1 (EC 2.7.1.37) (S6K) (S6K1) (70 KDA RIBOSOMAL PROTEIN S6 KINASE 1) (P70 S6 KINASE ALPHA) (P70(S6K)-ALPHA) (P70-S6K) (P70-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P23443]
T45597
T94479

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
Interpro Acc	IPR002290
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Target Class	Enzymes
Target Subclass	EC:2.7.11.1
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Palanki et al., 2007, Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction., J. Med. Chem.
Liu P et al., 2009, Targeting the phosphoinositide 3-kinase pathway in cancer., Nat Rev Drug Discov
Schalm et al., 2002, Identification of a conserved motif required for mTOR signaling., Curr. Biol.
Martin et al., 2001, Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation., J. Biol. Chem.
Martin et al., 2001, Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway., J. Biol. Chem.

LY-2584702 RPS6KB1

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribosomal protein S6 kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
XL-418 RPS6KB1

Interaction Score: 1.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name XL418

Novel drug target Novel Target

Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

PMIDs:
19644473

Sources:
TdgClinicalTrial ChemblInteractions TTD
TG100-115 RPS6KB1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17685602

Sources:
DTC
MSC-2363318A RPS6KB1

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
LY-2780301 RPS6KB1

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL210618 RPS6KB1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL259850 RPS6KB1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHIR-99021 RPS6KB1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VATALANIB RPS6KB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SIROLIMUS RPS6KB1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11967149 11108720 11108711

Sources:
NCI
CI-1040 RPS6KB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL578061 RPS6KB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE RPS6KB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FASUDIL RPS6KB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SNS-314 RPS6KB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 RPS6KB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A RPS6KB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE RPS6KB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SOTRASTAURIN RPS6KB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X RPS6KB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 RPS6KB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB RPS6KB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB RPS6KB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB RPS6KB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000108443
- Version: 101_38
Alternate Names:

RPS6KB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P23443
- Version: 11-September-2012
Alternate Names:

P23443 Uniprot Accession

RPS6KB1 Uniprot Gene Name

6198 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Human Readable Name KINASE

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000108443

Version: 26-July-2011

Alternate Names:

RIBOSOMAL PROTEIN S6 KINASE 1 (EC 2.7.1.37) (S6K) (S6K1) (70 KDA RIBOSOMAL PROTEIN S6 KINASE 1) (P70 S6 KINASE ALPHA) (P70(S6K)-ALPHA) (P70-S6K) (P70-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P23443] Description

RPS6KB1 Display Id

ENSG00000108443 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P23443
- Version: January-2014
Alternate Names:

RPS6KB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:
TTD: Ribosomal protein S6 kinase
- Version: 2020.06.01
Alternate Names:

S6K TTD Gene Abbreviation

T45597 TTD Target ID

Gene Info:

Publications:

Liu P et al., 2009, Targeting the phosphoinositide 3-kinase pathway in cancer., Nat Rev Drug Discov

NCI: RPS6KB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Martin et al., 2001, Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation., J. Biol. Chem.

Martin et al., 2001, Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway., J. Biol. Chem.

Schalm et al., 2002, Identification of a conserved motif required for mTOR signaling., Curr. Biol.

DTC: RPS6KB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Palanki et al., 2007, Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction., J. Med. Chem.

ChemblInteractions: STK14A
- Version: chembl_23
Alternate Names:

STK14A GENE_SYMBOL

RPS6KB1 GENE_SYMBOL

Ribosomal protein S6 kinase beta-1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000108443
- Version: 31-May-2017
Alternate Names:

ENSG00000108443 Gene Symbol

RPS6KB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: RPS6KB1
- Version: 01-February-2022
Alternate Names:

STK14A GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, SERINE THREONINE KINASE

Publications:
Tempus: RPS6KB1
- Version: 11-November-2018
Alternate Names:

RPS6KB1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: RPS6KB1
- Version: 27-Jun-2013
Alternate Names:

6198 Gene ID

PS6K dGene Synonym

S6K dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Ribosomal protein S6 kinase beta-1
- Version: 2020.06.01
Alternate Names:

S6K1 TTD Gene Abbreviation

T94479 TTD Target ID

Gene Info:

Publications:
Pharos: RPS6KB1
- Version: 01-February-2022
Alternate Names:

Ribosomal protein S6 kinase beta-1 Gene Name

P23443 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Ribosomal protein S6 kinase 1 inhibitor

Trial Name	XL418
Novel drug target	Novel Target
Mechanism of Interaction	Ribosomal protein S6 kinase (P70S6K) inhibitor

P23443	Uniprot Accession
RPS6KB1	Uniprot Gene Name
6198	Entrez Gene Id

RIBOSOMAL PROTEIN S6 KINASE 1 (EC 2.7.1.37) (S6K) (S6K1) (70 KDA RIBOSOMAL PROTEIN S6 KINASE 1) (P70 S6 KINASE ALPHA) (P70(S6K)-ALPHA) (P70-S6K) (P70-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P23443]	Description
RPS6KB1	Display Id
ENSG00000108443	Ensembl Gene Id

STK14A	GENE_SYMBOL
RPS6KB1	GENE_SYMBOL
Ribosomal protein S6 kinase beta-1	UNIPROT

RPS6KB1 Gene Record

RPS6KB1 6198 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Ribosomal protein S6 kinase 1 inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name XL418 Novel drug target Novel Target Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

PMIDs: 19644473

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17685602

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11967149 11108720 11108711

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribosomal protein S6 kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name XL418

Novel drug target Novel Target

Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

PMIDs:
19644473

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
17685602

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribosomal protein S6 kinase (P70S6K) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11967149 11108720 11108711

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a