6608 |
SMOOTHENED, FRIZZLED CLASS RECEPTOR |
SMO |
CRJS |
FZD11 |
Gx |
SMOH |
601500 |
11119 |
ENSG00000128602 |
OTTHUMG00000158421 |
Q99835 |
Smoothened homolog |
Protein Gx |
SMOOTHENED |
5365 |
T66505 |
PHLS |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Frizzled |
Gene Biotype | PROTEIN_CODING |
DRUG RESISTANCE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Smoothened homolog inhibitor |
Notes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Smoothened homolog antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Smoothened homolog antagonist |
Direct Interaction | yes |
Indication/Tumor Type | Advanced Solid Tumor |
antagonist (inhibitory) |
Mechanism of Interaction | Smoothened homolog antagonist |
Direct Interaction | yes |
Indication/Tumor Type | Advanced Solid Tumor |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Novel drug target | Novel Target |
Trial Name | LDE225 |
combination therapy | Gefitinib + Sonidegib |
antagonist (inhibitory) |
Mechanism of Interaction | Smoothened homolog antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Smoothened homolog antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Smoothened homolog antagonist |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Smoothened homolog inhibitor |
Direct Interaction | yes |
SMO | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
SMO | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Frizzled |
6608 | CKB Entrez Id |
SMO | CKB Gene Synonym |
CRJS | CKB Gene Synonym |
6608 | Entrez Gene ID |
5365 | CIViC Gene ID |
DRUG RESISTANCE |
6608 | Entrez Gene Id |
SMO | MyCancerGenome Gene Symbol |
Smoothened | MyCancerGenome Reported Gene Name |
SMOH | GENE_SYMBOL |
SMO | GENE_SYMBOL |
Smoothened homolog | UNIPROT |
ENSG00000128602 | Gene Symbol |
SMO | Ensembl Id |
DRUGGABLE GENOME |
SMO | Gene Symbol |
SMOH | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
SMO | Gene Symbol |
CLINICALLY ACTIONABLE |
6608 | Gene ID |
FZD11 | dGene Synonym |
Gx | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
SMO | TTD Gene Abbreviation |
T66505 | TTD Target ID |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
DRUG RESISTANCE |