SPR Gene Record

  • SPR 6697 Druggable Genome

    Alternate Names:

    6697
    SEPIAPTERIN REDUCTASE
    SPR
    SDR38C1
    182125
    11257
    ENSG00000116096
    OTTHUMG00000129777
    P35270
    NK1R
    NK-1R
    TACR1
    TAC1R
    Tachykinin receptor 1
    NK-1 receptor
    Substance-P receptor
    SPRE_HUMAN
    SEPIAPTERIN REDUCTASE (EC 1.1.1.153) (SPR). [SOURCE:UNIPROT/SWISSPROT;ACC:P35270]

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Acc IPR002198
    Interpro Name Short-chain dehydrogenase/reductase SDR
    Interpro Short Name DH_sc/Rdtase_SDR
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    SHORT CHAIN DEHYDROGENASE REDUCTASE
    ENZYME

    Publications:

  • ROLAPITANT HYDROCHLORIDE   SPR

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EZLOPITANT   SPR

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSAPREPITANT DIMEGLUMINE   SPR

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VESTIPITANT MESYLATE   SPR

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BURAPITANT   SPR

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DNK333   SPR

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NETUPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SERLOPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CASOPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORVEPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neurokinin 1 receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VOFOPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRADIPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neurokinin 1 receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FIGOPITANT   SPR

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Neurokinin 1 receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • APREPITANT   SPR

    Interaction Score: 1.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Neurokinin 1 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000116096

    • Version: 101_38

    Alternate Names:
    SPR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P35270

    • Version: 11-September-2012

    Alternate Names:
    6697 Entrez Gene Id
    SPR Uniprot Gene Name
    SEPIAPTERIN REDUCTASE Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002198
    Interpro Name Short-chain dehydrogenase/reductase SDR

    Gene Categories:
    DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

    Publications:

  • RussLampel: ENSG00000116096

    • Version: 26-July-2011

    Alternate Names:
    SPR Display Id
    SEPIAPTERIN REDUCTASE (EC 1.1.1.153) (SPR). [SOURCE:UNIPROT/SWISSPROT;ACC:P35270] Description
    ENSG00000116096 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NK1R

    • Version: chembl_23

    Alternate Names:
    TAC1R GENE_SYMBOL
    TACR1 GENE_SYMBOL
    Substance-P receptor UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: SPR

    • Version: 19.3

    Alternate Names:
    ENSG00000116096 Ensembl Gene ID
    SDR38C1 Human Protein Atlas Gene Synonym
    Sepiapterin reductase Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications: