DGIdb - SSTR2 Gene Record

SSTR2 6752 Druggable Genome

Alternate Names:

6752
SOMATOSTATIN RECEPTOR 2
SSTR2
182452
11331
ENSG00000180616
OTTHUMG00000178343
P30874
SSR2_HUMAN
SOMATOSTATIN RECEPTOR TYPE 2
SS2R
SRIF-1
SS2-R
SS-2-R
SOMATOSTATIN RECEPTOR TYPE 2 (SS2R) (SRIF-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P30874]
T53024
-

Gene Info:

Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Uniprot Status	Swiss-Prot
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Fortune et al., 2009, Vapreotide: a somatostatin analog for the treatment of acute variceal bleeding., Expert Opin Pharmacother
Strowski et al., 2000, Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice., Endocrinology
Zatelli et al., 2007, Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion., Endocr. Relat. Cancer
Bruns et al., 2002, SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile., Eur. J. Endocrinol.
Yim et al., 2009, Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers., Bioconjug. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Plöckinger et al., 2008, Selective loss of somatostatin receptor 2 in octreotide-resistant growth hormone-secreting adenomas., J. Clin. Endocrinol. Metab.
Shimon, 2003, Somatostatin receptors in pituitary and development of somatostatin receptor subtype-selective analogs., Endocrine
Grace CR et al., 2008, Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity., J Med Chem
Janson et al., 1996, A comparison between the efficacy of somatostatin receptor scintigraphy and that of in situ hybridization for somatostatin receptor subtype 2 messenger RNA to predict therapeutic outcome in carcinoid patients., Cancer Res.

VAPREOTIDE ACETATE SSTR2

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8653698

Sources:
NCI
CHEMBL442494 SSTR2

Interaction Score: 5.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
18410083

Sources:
DTC
PASIREOTIDE SSTR2

Interaction Score: 5.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name pasireotide, SOM230

Novel drug target Established target

PMIDs:
17395978 11980628

Sources:
TdgClinicalTrial TTD
VAPREOTIDE SSTR2

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 2 agonist

Direct Interaction yes

Trial Name vapreotide, Debio 8609,Sanvar, Docrised

PMIDs:
19708854

Sources:
TdgClinicalTrial ChemblInteractions
OCTREOTIDE SSTR2

Interaction Score: 3.61

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Trial Name oral octreotide actetate,Octreolin

Trial Name octrotide,Atrigel

Trial Name injectable octreotide acetate,Sandostatin LAR

PMIDs:
19537708 11752352 18198230 12721506

Sources:
TdgClinicalTrial NCI TTD
LANREOTIDE ACETATE SSTR2

Interaction Score: 2.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PASIREOTIDE DIASPARTATE SSTR2

Interaction Score: 1.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VELDOREOTIDE SSTR2

Interaction Score: 1.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name DG3173

PMIDs:
None found

Sources:
TdgClinicalTrial
PASIREOTIDE PAMOATE SSTR2

Interaction Score: 1.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Somatostatin receptor 2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
OCTREOTIDE ACETATE SSTR2

Interaction Score: 1.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL452157 SSTR2

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INSULIN SSTR2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10614629

Sources:
NCI

Ensembl: ENSG00000180616
- Version: 101_38
Alternate Names:

SSTR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P30874
- Version: January-2014
Alternate Names:

SSTR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P30874
- Version: 11-September-2012
Alternate Names:

SSR2_HUMAN Uniprot Id

SOMATOSTATIN RECEPTOR TYPE 2 Uniprot Protein Name

P30874 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000180616
- Version: 26-July-2011
Alternate Names:

ENSG00000180616 Ensembl Gene Id

SSTR2 Display Id

SOMATOSTATIN RECEPTOR TYPE 2 (SS2R) (SRIF-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P30874] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: SSTR2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Strowski et al., 2000, Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice., Endocrinology

Shimon, 2003, Somatostatin receptors in pituitary and development of somatostatin receptor subtype-selective analogs., Endocrine

Plöckinger et al., 2008, Selective loss of somatostatin receptor 2 in octreotide-resistant growth hormone-secreting adenomas., J. Clin. Endocrinol. Metab.

DTC: SSTR2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Grace CR et al., 2008, Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity., J Med Chem
HingoraniCasas: ENSG00000180616
- Version: 31-May-2017
Alternate Names:

ENSG00000180616 Gene Symbol

SSTR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: SSTR2
- Version: chembl_23
Alternate Names:

SSTR2 GENE_SYMBOL

Somatostatin receptor type 2 UNIPROT

SRIF-1 UNIPROT

Gene Info:

Publications:
dGene: SSTR2
- Version: 27-Jun-2013
Alternate Names:

6752 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Somatostatin receptor type 2
- Version: 2020.06.01
Alternate Names:

SSTR2 TTD Gene Abbreviation

T53024 TTD Target ID

Gene Info:

Publications:
GO: SSTR2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	pasireotide, SOM230
Novel drug target	Established target

Mechanism of Interaction	Somatostatin receptor 2 agonist
Direct Interaction	yes
Trial Name	vapreotide, Debio 8609,Sanvar, Docrised

Trial Name	oral octreotide actetate,Octreolin
Trial Name	octrotide,Atrigel
Trial Name	injectable octreotide acetate,Sandostatin LAR

Mechanism of Interaction	Somatostatin receptor agonist
Direct Interaction	yes

SSR2_HUMAN	Uniprot Id
SOMATOSTATIN RECEPTOR TYPE 2	Uniprot Protein Name
P30874	Uniprot Accession

ENSG00000180616	Ensembl Gene Id
SSTR2	Display Id
SOMATOSTATIN RECEPTOR TYPE 2 (SS2R) (SRIF-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P30874]	Description

SSTR2	GENE_SYMBOL
Somatostatin receptor type 2	UNIPROT
SRIF-1	UNIPROT

agonist (activating)
inducer (activating)

agonist (activating)
binder

SSTR2 Gene Record

SSTR2 6752 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8653698

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 18410083

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name pasireotide, SOM230 Novel drug target Established target

PMIDs: 17395978 11980628

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: agonist (activating) inducer (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor 2 agonist Direct Interaction yes Trial Name vapreotide, Debio 8609,Sanvar, Docrised

PMIDs: 19708854

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating) binder

Interaction Info: Trial Name oral octreotide actetate,Octreolin Trial Name octrotide,Atrigel Trial Name injectable octreotide acetate,Sandostatin LAR

PMIDs: 19537708 11752352 18198230 12721506

Sources: TdgClinicalTrial NCI TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor 2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor 2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name DG3173

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Somatostatin receptor 2 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Somatostatin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10614629

Sources: NCI

Ensembl: ENSG00000180616

Alternate Names: SSTR2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P30874

Alternate Names: SSTR2 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

HopkinsGroom: P30874

Alternate Names: SSR2_HUMAN Uniprot Id SOMATOSTATIN RECEPTOR TYPE 2 Uniprot Protein Name P30874 Uniprot Accession

Gene Info: Uniprot Status Swiss-Prot Human Readable Name G PROTEIN COUPLED RECEPTOR Human Readable Name DRUGGABLE GENOME

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000180616

Alternate Names: ENSG00000180616 Ensembl Gene Id SSTR2 Display Id SOMATOSTATIN RECEPTOR TYPE 2 (SS2R) (SRIF-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P30874] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: SSTR2

Alternate Names:

Gene Info:

DTC: SSTR2

Alternate Names:

Gene Info:

Publications: Grace CR et al., 2008, Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity., J Med Chem

HingoraniCasas: ENSG00000180616

Interaction Types & Directionality:

n/a

PMIDs:
8653698

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

PMIDs:
18410083

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name pasireotide, SOM230

Novel drug target Established target

PMIDs:
17395978 11980628

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

agonist (activating)

inducer (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 2 agonist

Direct Interaction yes

Trial Name vapreotide, Debio 8609,Sanvar, Docrised

PMIDs:
19708854

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Trial Name oral octreotide actetate,Octreolin

Trial Name octrotide,Atrigel

Trial Name injectable octreotide acetate,Sandostatin LAR

PMIDs:
19537708 11752352 18198230 12721506

Sources:
TdgClinicalTrial NCI TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name DG3173

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Somatostatin receptor 2 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Somatostatin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
10614629

Sources:
NCI

Alternate Names:

SSTR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SSTR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

SSR2_HUMAN Uniprot Id

SOMATOSTATIN RECEPTOR TYPE 2 Uniprot Protein Name

P30874 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

ENSG00000180616 Ensembl Gene Id

SSTR2 Display Id

SOMATOSTATIN RECEPTOR TYPE 2 (SS2R) (SRIF-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P30874] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

Grace CR et al., 2008, Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity., J Med Chem

Alternate Names:

ENSG00000180616 Gene Symbol

SSTR2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SSTR2 GENE_SYMBOL

Somatostatin receptor type 2 UNIPROT

SRIF-1 UNIPROT

Alternate Names:

6752 Gene ID

- dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

SSTR2 TTD Gene Abbreviation

T53024 TTD Target ID

Gene Categories:

G PROTEIN COUPLED RECEPTOR