DGIdb - TAAR1 Gene Record

TAAR1 134864 Druggable Genome

Alternate Names:

134864
TRACE AMINE ASSOCIATED RECEPTOR 1
TAAR1
TA1
TAR1
TRAR1
609333
17734
ENSG00000146399
OTTHUMG00000015583
Q96RJ0
TAAR1_HUMAN
TRACE AMINE-ASSOCIATED RECEPTOR 1
TRACE AMINE RECEPTOR 1 (TAR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RJ0]
Trace amine-associated receptor-1
T99524
RP11-295F4.9

Gene Info:

Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Type	Family
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	7TM_GPCR_Rhodpsn
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Borowsky et al., 2001, Trace amines: identification of a family of mammalian G protein-coupled receptors., Proc. Natl. Acad. Sci. U.S.A.
Grandy, 2007, Trace amine-associated receptor 1-Family archetype or iconoclast?, Pharmacol. Ther.
Wolinsky et al., 2007, The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia., Genes Brain Behav.
Xie et al., 2007, Trace amine-associated receptor 1 is a modulator of the dopamine transporter., J. Pharmacol. Exp. Ther.
Miller et al., 2005, Primate trace amine receptor 1 modulation by the dopamine transporter., J. Pharmacol. Exp. Ther.
Xie et al., 2007, Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro., J. Pharmacol. Exp. Ther.
Reese et al., 2007, Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine., J. Pharmacol. Exp. Ther.
Liu JF et al., 2018, TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg., Front Pharmacol
Pei Y et al., 2016, Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications., Front Neurosci
Miller GM, 2011, The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity., J Neurochem

PHENACYLAMINE HYDROCHLORIDE TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1183425 TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FORMETOREX TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXTROAMPHETAMINE TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17234900 17218486 15764732 17234899 17212650

Sources:
TTD
LISDEXAMFETAMINE TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
29636691 27092049 21073468

Sources:
TTD
CHEMBL1224310 TAAR1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMPHETAMINE TAAR1

Interaction Score: 1.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name SLI 381, SPD 465,Adderall, Adderall XR, Adderall IR

Novel drug target Established target

Trial Name C105, levo-amphetamine sulfate

PMIDs:
17234900 17218486 15764732 17234899 17212650

Sources:
TdgClinicalTrial TTD
TRANYLCYPROMINE HYDROCHLORIDE TAAR1

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL590666 TAAR1

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GUANABENZ TAAR1

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANTAZOLINE HYDROCHLORIDE TAAR1

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL530698 TAAR1

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANTAZOLINE PHOSPHATE TAAR1

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL524376 TAAR1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TYRAMINE TAAR1

Interaction Score: 0.74

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHAMPHETAMINE TAAR1

Interaction Score: 0.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name low dose intravenous methamphetamine

PMIDs:
11459929 17888514 17212650 17234899 15764732 17234900 17218486

Sources:
TdgClinicalTrial
CHEMBL546344 TAAR1

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL591598 TAAR1

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL579919 TAAR1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL525826 TAAR1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NAPHAZOLINE HYDROCHLORIDE TAAR1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TETRAHYDROZOLINE HYDROCHLORIDE TAAR1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROROXAN HYDROCHLORIDE TAAR1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENOLDOPAM MESYLATE TAAR1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL553503 TAAR1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOLAZOLINE HYDROCHLORIDE TAAR1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL284609 TAAR1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDROXYAMPHETAMINE HYDROBROMIDE TAAR1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000146399
- Version: 101_38
Alternate Names:

TAAR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q96RJ0
- Version: January-2014
Alternate Names:

TAAR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: Q96RJ0
- Version: 11-September-2012
Alternate Names:

TAAR1_HUMAN Uniprot Id

TAAR1 Uniprot Gene Name

134864 Entrez Gene Id

Gene Info:

Interpro Acc IPR000276

Interpro Name GPCR, rhodopsin-like, 7TM

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000146399
- Version: 26-July-2011
Alternate Names:

ENSG00000146399 Ensembl Gene Id

TRACE AMINE RECEPTOR 1 (TAR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RJ0] Description

TAAR1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000146399
- Version: 31-May-2017
Alternate Names:

ENSG00000146399 Gene Symbol

TAAR1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: TAAR1
- Version: 01-February-2022
Alternate Names:

TA1 GO Gene Synonym

TAR1 GO Gene Synonym

TRAR1 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: TAAR1
- Version: 27-Jun-2013
Alternate Names:

134864 Gene ID

RP11-295F4.9 dGene Synonym

TA1 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Trace amine-associated receptor-1
- Version: 2020.06.01
Alternate Names:

TAAR1 TTD Gene Abbreviation

T99524 TTD Target ID

Gene Info:

Publications:
DTC: TAAR1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Trial Name	SLI 381, SPD 465,Adderall, Adderall XR, Adderall IR
Novel drug target	Established target
Trial Name	C105, levo-amphetamine sulfate

TAAR1_HUMAN	Uniprot Id
TAAR1	Uniprot Gene Name
134864	Entrez Gene Id

ENSG00000146399	Ensembl Gene Id
TRACE AMINE RECEPTOR 1 (TAR-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96RJ0]	Description
TAAR1	Display Id

TAAR1 Gene Record

TAAR1 134864 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 17234900 17218486 15764732 17234899 17212650

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 29636691 27092049 21073468

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name SLI 381, SPD 465,Adderall, Adderall XR, Adderall IR Novel drug target Established target Trial Name C105, levo-amphetamine sulfate

PMIDs: 17234900 17218486 15764732 17234899 17212650

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name low dose intravenous methamphetamine

PMIDs: 11459929 17888514 17212650 17234899 15764732 17234900 17218486

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
17234900 17218486 15764732 17234899 17212650

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
29636691 27092049 21073468

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name SLI 381, SPD 465,Adderall, Adderall XR, Adderall IR

Novel drug target Established target

Trial Name C105, levo-amphetamine sulfate

PMIDs:
17234900 17218486 15764732 17234899 17212650

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name low dose intravenous methamphetamine

PMIDs:
11459929 17888514 17212650 17234899 15764732 17234900 17218486

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC