• TEK 7010 Druggable GenomeClinically Actionable

    Alternate Names:

    7010
    TEK RECEPTOR TYROSINE KINASE
    TEK
    CD202B
    GLC3E
    TIE-2
    TIE2
    VMCM
    VMCM1
    600221
    11724
    ENSG00000120156
    OTTHUMG00000019712
    Tyrosine-protein kinase receptor TIE-2
    p140 TEK
    CD_antigen=CD202b
    hTIE2
    Angiopoietin-1 receptor
    Tyrosine-protein kinase receptor TEK
    Endothelial tyrosine kinase
    Tunica interna endothelial cell kinase
    Tyrosine kinase with Ig and EGF homology domains-2
    ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763]
    Q02763
    ANGIOPOIETIN 1 RECEPTOR
    TIE2_HUMAN
    T92144

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Subclass EC:2.7.10.1
    Target Class Receptors
    Human Readable Name KINASE
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001245
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
  • Interaction Score: 3.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17884497


    Sources:
    DTC

  • Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • Interaction Score: 1.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes
    Trial Name ARRY-614

    PMIDs:
    None found


  • Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name MGCD265
    Notes

    PMIDs:
    None found


  • Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name regorafenib, BAY 73-4506
    Novel drug target Novel Target
    Notes

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ABT-869, Linifanib

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial