7010 |
TEK RECEPTOR TYROSINE KINASE |
TEK |
CD202B |
GLC3E |
TIE-2 |
TIE2 |
VMCM |
VMCM1 |
600221 |
11724 |
ENSG00000120156 |
OTTHUMG00000019712 |
Tyrosine-protein kinase receptor TIE-2 |
p140 TEK |
CD_antigen=CD202b |
hTIE2 |
Angiopoietin-1 receptor |
Tyrosine-protein kinase receptor TEK |
Endothelial tyrosine kinase |
Tunica interna endothelial cell kinase |
Tyrosine kinase with Ig and EGF homology domains-2 |
ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763] |
Q02763 |
ANGIOPOIETIN 1 RECEPTOR |
TIE2_HUMAN |
T92144 |
Human Readable Name | DRUGGABLE GENOME |
Target Subclass | EC:2.7.10.1 |
Target Class | Receptors |
Human Readable Name | KINASE |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR001245 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
TYROSINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
Trial Name | ARRY-614 |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Novel drug target | Novel Target |
Trial Name | MGCD265 |
Notes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | regorafenib, BAY 73-4506 |
Novel drug target | Novel Target |
Notes |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
n/a |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase TIE-2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | ABT-869, Linifanib |
TEK | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
7010 | Entrez Gene Id |
Q02763 | Uniprot Accession |
TEK | Uniprot Gene Name |
Human Readable Name | KINASE |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Evidence | 1: Evidence at protein level |
KINASE, DRUGGABLE GENOME |
ENSG00000120156 | Ensembl Gene Id |
TEK | Display Id |
ANGIOPOIETIN 1 RECEPTOR PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR TIE-2) (TYROSINE-PROTEIN KINASE RECEPTOR TEK) (P140 TEK) (TUNICA INTERNA ENDOTHELIAL CELL KINASE) (CD202B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02763] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
TIE2 | Gene Symbol |
TEK | Gene Symbol |
Target Subclass | EC:2.7.10.1 |
Target Class | Receptors |
TIE2 | Gene Symbol |
TIE-2 | Gene Symbol |
ENSG00000120156 | Gene Symbol |
TEK | Ensembl Id |
DRUGGABLE GENOME |
VMCM | GENE_SYMBOL |
VMCM1 | GENE_SYMBOL |
TEK | GENE_SYMBOL |
TIE2 | GO Gene Synonym |
VMCM | GO Gene Synonym |
VMCM1 | GO Gene Synonym |
CELL SURFACE, TYROSINE KINASE |
7010 | Gene ID |
CD202B | dGene Synonym |
TIE-2 | dGene Synonym |
KINASE, TYROSINE KINASE |
TEK | TTD Gene Abbreviation |
T92144 | TTD Target ID |
Angiopoietin-1 receptor | Gene Name |
Q02763 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |