• TGFBR1 7046 Druggable GenomeClinically Actionable

    Alternate Names:

    7046
    TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1
    TGFBR1
    AAT5
    ACVRLK4
    ALK-5
    ALK5
    ESS1
    LDS1
    LDS1A
    LDS2A
    MSSE
    SKR4
    TGFR-1
    tbetaR-I
    190181
    11772
    ENSG00000106799
    OTTHUMG00000020353
    P36897
    TGF-beta receptor type I
    Transforming growth factor-beta receptor type I
    TGF-beta type I receptor
    Serine/threonine-protein kinase receptor R4
    Activin receptor-like kinase 5
    Activin A receptor type II-like protein kinase of 53kD
    TGF-beta receptor type-1
    TGF-BETA RECEPTOR TYPE I PRECURSOR (EC 2.7.1.37) (TGFR-1) (TGF-BETA TYPE I RECEPTOR) (SERINE/THREONINE-PROTEIN KINASE RECEPTOR R4) (SKR4) (ACTIVIN RECEPTOR-LIKE KINASE 5) (ALK-5). [SOURCE:UNIPROT/SWISSPROT;ACC:P36897]
    T53389
    TBR-i
    TBRI

    Gene Info:

    Target Class Receptors
    Target Subclass EC:2.7.11.30
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    TUMOR SUPPRESSOR
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 10.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction TGF-beta receptor type I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:


    Sources:
    DTC

  • Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 5.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    TGFBR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    TGF-BETA RECEPTOR TYPE I PRECURSOR (EC 2.7.1.37) (TGFR-1) (TGF-BETA TYPE I RECEPTOR) (SERINE/THREONINE-PROTEIN KINASE RECEPTOR R4) (SKR4) (ACTIVIN RECEPTOR-LIKE KINASE 5) (ALK-5). [SOURCE:UNIPROT/SWISSPROT;ACC:P36897] Description
    ENSG00000106799 Ensembl Gene Id
    TGFBR1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    TGFBR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:2.7.11.30

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000106799 Gene Symbol
    TGFBR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    SKR4 GENE_SYMBOL
    TGFBR1 GENE_SYMBOL
    TGF-beta receptor type-1 UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000106799 Ensembl Gene ID
    ACVRLK4 Human Protein Atlas Gene Synonym
    ALK-5 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 01-February-2022

    Alternate Names:
    ALK5 GO Gene Synonym
    SKR4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TUMOR SUPPRESSOR, SERINE THREONINE KINASE

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    7046 Gene ID
    AAT5 dGene Synonym
    ACVRLK4 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    TGFBR1 TTD Gene Abbreviation
    T53389 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-February-2022

    Alternate Names:
    TGF-beta receptor type-1 Gene Name
    P36897 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: