DGIdb - TNFRSF10B Gene Record

TNFRSF10B 8795 Druggable Genome

Alternate Names:

8795
TNF RECEPTOR SUPERFAMILY MEMBER 10B
TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
603612
11905
ENSG00000120889
OTTHUMG00000097826
Tumor necrosis factor receptor superfamily member 10B
Death receptor 5
TNF-related apoptosis-inducing ligand receptor 2
CD_antigen=CD262
TRAIL receptor 2
O14763
TRAIL-R2/D5
TRAIL-R1/DR4,R2/D5
T70067
UNQ160/PRO186

Gene Info:

Target Class	Receptors
Target Subclass	Receptors
Target Subclass	TNFNGF
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Toume K et al., 2011, Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity., J Nat Prod
Maddipatla S et al., 2007, Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20., Clin Cancer Res
Zhang X et al., 2007, Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells., Clin Cancer Res

LEXATUMUMAB TNFRSF10B

Interaction Score: 53.0

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Trial Name lexatumumab, HGS-ETR2, TRAIL-R2

Novel drug target Novel Target

Notes

PMIDs:
17671142 18056199

Sources:
TALC MyCancerGenome TdgClinicalTrial TTD
DROZITUMAB TNFRSF10B

Interaction Score: 17.67

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions
DULANERMIN TNFRSF10B

Interaction Score: 13.25

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions
CONATUMUMAB TNFRSF10B

Interaction Score: 8.83

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions TTD
APOMAB TNFRSF10B

Interaction Score: 8.83

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
TIGATUZUMAB TNFRSF10B

Interaction Score: 8.83

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

PMIDs:
None found

Sources:
ChemblInteractions
LUTEOLIN TNFRSF10B

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21265555

Sources:
DTC

Ensembl: ENSG00000120889
- Version: 101_38
Alternate Names:

TNFRSF10B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O14763
- Version: January-2014
Alternate Names:

TNFRSF10B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TNFNGF

Publications:
DTC: TNFRSF10B
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Toume K et al., 2011, Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity., J Nat Prod
MyCancerGenome: TNFRSF10B
- Version: 20-Jun-2017
Alternate Names:

8795 Entrez Gene Id

TNFRSF10B MyCancerGenome Gene Symbol

TRAIL-R2/D5 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
TALC: DR5
- Version: 12-May-2016
Alternate Names:

DR5 Gene Symbol

Gene Info:

Publications:
TALC: TRAIL-R2
- Version: 12-May-2016
Alternate Names:

TRAIL-R2 Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000120889
- Version: 31-May-2017
Alternate Names:

ENSG00000120889 Gene Symbol

TNFRSF10B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: DR5
- Version: chembl_23
Alternate Names:

KILLER GENE_SYMBOL

TRAILR2 GENE_SYMBOL

TRICK2 GENE_SYMBOL

Gene Info:

Publications:
GO: TNFRSF10B
- Version: 01-February-2022
Alternate Names:

DR5 GO Gene Synonym

KILLER GO Gene Synonym

TRAILR2 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: TRAIL receptor 2
- Version: 2020.06.01
Alternate Names:

TRAIL-R2 TTD Gene Abbreviation

T70067 TTD Target ID

Gene Info:

Publications:

Trial Name	lexatumumab, HGS-ETR2, TRAIL-R2
Novel drug target	Novel Target
Notes

Mechanism of Interaction	Tumor necrosis factor receptor superfamily member 10B agonist
Direct Interaction	yes
Notes

8795	Entrez Gene Id
TNFRSF10B	MyCancerGenome Gene Symbol
TRAIL-R2/D5	MyCancerGenome Reported Gene Name

DR5	GO Gene Synonym
KILLER	GO Gene Synonym
TRAILR2	GO Gene Synonym

agonist (activating)
antibody (inhibitory)

agonist (activating)
antibody (inhibitory)

agonist (activating)
antibody (inhibitory)

agonist (activating)
antibody (inhibitory)

TNFRSF10B Gene Record

TNFRSF10B 8795 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

LEXATUMUMAB TNFRSF10B

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info: Trial Name lexatumumab, HGS-ETR2, TRAIL-R2 Novel drug target Novel Target Notes

PMIDs: 17671142 18056199

Sources: TALC MyCancerGenome TdgClinicalTrial TTD

DROZITUMAB TNFRSF10B

Interaction Types & Directionality: agonist (activating) antibody (inhibitory)

Interaction Info: Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist Direct Interaction yes Notes

PMIDs: None found

Sources: TALC ChemblInteractions

DULANERMIN TNFRSF10B

Interaction Types & Directionality: agonist (activating) antibody (inhibitory)

Interaction Info: Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions

CONATUMUMAB TNFRSF10B

Interaction Types & Directionality: agonist (activating) antibody (inhibitory)

Interaction Info: Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions TTD

APOMAB TNFRSF10B

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

TIGATUZUMAB TNFRSF10B

Interaction Types & Directionality: agonist (activating) antibody (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

PMIDs: None found

Sources: ChemblInteractions

LUTEOLIN TNFRSF10B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21265555

Sources: DTC

Ensembl: ENSG00000120889

Alternate Names: TNFRSF10B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: O14763

Alternate Names: TNFRSF10B Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass TNFNGF

Publications:

DTC: TNFRSF10B

Alternate Names:

Gene Info:

Publications: Toume K et al., 2011, Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity., J Nat Prod

MyCancerGenome: TNFRSF10B

Alternate Names: 8795 Entrez Gene Id TNFRSF10B MyCancerGenome Gene Symbol TRAIL-R2/D5 MyCancerGenome Reported Gene Name

Gene Info:

Publications:

TALC: DR5

Alternate Names: DR5 Gene Symbol

Gene Info:

Publications:

TALC: TRAIL-R2

Alternate Names: TRAIL-R2 Gene Symbol

Gene Info:

Publications:

HingoraniCasas: ENSG00000120889

Alternate Names: ENSG00000120889 Gene Symbol TNFRSF10B Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: DR5

Alternate Names: KILLER GENE_SYMBOL TRAILR2 GENE_SYMBOL TRICK2 GENE_SYMBOL

Gene Info:

Publications:

GO: TNFRSF10B

Alternate Names: DR5 GO Gene Synonym KILLER GO Gene Synonym TRAILR2 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

TTD: TRAIL receptor 2

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

Trial Name lexatumumab, HGS-ETR2, TRAIL-R2

Novel drug target Novel Target

Notes

PMIDs:
17671142 18056199

Sources:
TALC MyCancerGenome TdgClinicalTrial TTD

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

agonist (activating)

antibody (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tumor necrosis factor receptor superfamily member 10B agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21265555

Sources:
DTC

Alternate Names:

TNFRSF10B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TNFRSF10B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TNFNGF

Publications:

Toume K et al., 2011, Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity., J Nat Prod

Alternate Names:

8795 Entrez Gene Id

TNFRSF10B MyCancerGenome Gene Symbol

TRAIL-R2/D5 MyCancerGenome Reported Gene Name

Alternate Names:

DR5 Gene Symbol

Alternate Names:

TRAIL-R2 Gene Symbol

Alternate Names:

ENSG00000120889 Gene Symbol

TNFRSF10B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KILLER GENE_SYMBOL

TRAILR2 GENE_SYMBOL

TRICK2 GENE_SYMBOL

Alternate Names:

DR5 GO Gene Synonym

KILLER GO Gene Synonym

TRAILR2 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

TRAIL-R2 TTD Gene Abbreviation

T70067 TTD Target ID